&lt;i&gt;In vitro&lt;/i&gt; cytotoxicity of biosynthesized titanium dioxide nanoparticles in human prostate cancer cell lines

He, Feiping; Yu, Weixing; Fan, Xinping; Jin, Baiye

doi:10.4314/tjpr.v16i12.2

Cited by 26 publications

(7 citation statements)

References 18 publications

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“…Previous literature supports our findings by suggesting that TiO 2 nanoparticles are cytotoxic to various human cell lines and doping further improves the cytotoxic status of these nanoparticles [16]. He et al [45] elucidated concentration-dependent cytotoxic activity of TiO 2 nanoparticles in human prostate cancer cell lines. Chellappa et al [46], Ahamed et al [15], Rahmani Kukia et al [47] and Koca and Duman, [48] also reported the in vitro and in vivo cytotoxicity of TiO 2 nanoparticles.…”

Section: Resultssupporting

confidence: 88%

Appraisal of Comparative Therapeutic Potential of Undoped and Nitrogen-Doped Titanium Dioxide Nanoparticles

Ahmad

Yang

et al. 2019

Molecules

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Nitrogen-doped and undoped titanium dioxide nanoparticles were successfully fabricated by simple chemical method and characterized using x-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive x-ray (EDX), and transmission electron microscopy (TEM) techniques. The reduction in crystalline size of TiO2 nanoparticles (from 20–25 nm to 10–15 nm) was observed by TEM after doping with N. Antibacterial, antifungal, antioxidant, antidiabetic, protein kinase inhibition and cytotoxic properties were assessed in vitro to compare the therapeutic potential of both kinds of TiO2 nanoparticles. All biological activities depicted significant enhancement as a result of addition of N as doping agent to TiO2 nanoparticles. Klebsiella pneumoniae has been illuminated to be the most susceptible bacterial strain out of various Gram-positive and Gram-negative isolates of bacteria used in this study. Good fungicidal activity has been revealed against Aspergillus flavus. 38.2% of antidiabetic activity and 80% of cytotoxicity has been elucidated by N-doped TiO2 nanoparticles towards alpha-amylase enzyme and Artemia salina (brine shrimps), respectively. Moreover, notable protein kinase inhibition against Streptomyces and antioxidant effect including reducing power and % inhibition of DPPH has been demonstrated. This investigation unveils the more effective nature of N-doped TiO2 nanoparticles in comparison to undoped TiO2 nanoparticles indicated by various biological tests. Hence, N-doped TiO2 nanoparticles have more potential to be employed in biomedicine for the cure of numerous infections.

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Section: Resultssupporting

confidence: 88%

Appraisal of Comparative Therapeutic Potential of Undoped and Nitrogen-Doped Titanium Dioxide Nanoparticles

Ahmad

Yang

et al. 2019

Molecules

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“…Figure 1E shows that all the samples displayed two series of peaks, which belongs to the anatase-TiO 2 structure and the face-centered-cubic Au. The peaks at 2θ of 25.3, 47.9, 53.8, and 54.7 could be ascribed to the (101), (200), (105), and (211) planes of anatase-TiO 2 37, respectively, while the left peaks were corresponding to the (111), (200), (220), and (311) faces of face-centered-cubic Au. Thus, the presence of Au and TiO 2 in the Au@TiO 2 core-shell NPs were confirmed.…”

Section: Resultsmentioning

confidence: 97%

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Zheng

Wang

et al. 2019

Theranostics

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With advances in nanoparticle (NP) synthesis and engineering, nanoscale agents with both therapeutic and diagnostic functions have been increasingly exploited for cancer management. Herein, we synthesized a new type of zwitterionic polymer-gated Au@TiO 2 core-shell nanoparticles, which showed that they could selectively target and efficiently eliminate cancer cells via photothermal therapy (PTT), photodynamic therapy (PDT), pH/NIR-induced drug release, and cationic therapy. Methods : In the present study, the multifunctional therapeutic agent [Mn@P(CitAPDMAEMA)@Au@TiO 2 @DOX] was prepared to treat cancer with imaging-guided combination method. Firstly, Au@TiO 2 core-shell nanoparticles (NPs) were synthesized. Taking advantage of broad and strong photoabsorption and reactive oxygen species (ROS) generation, Au@TiO 2 core-shell NPs facilitated the single light-induced PTT and PDT. Next, a chemotherapy drug doxorubicin (DOX) was loaded into Au@TiO 2 core-shell NPs. Then, a biocompatible zwitterionic polymer P(CitAPDMAEMA) was grafted to improve the hemocompatibility of NPs and prolong the circulation time. The polymer also served as a capping or switching material for pH-triggered drug release. In addition, the cationic nature of P(CitAPDMAEMA) eased the binding to human cervical cancer (HeLa) cells and effectively inhibited their growth in acidic environments (termed cationic therapy). Moreover, with Mn 2+ ions immanently chelated, Mn@P(CitAPDMAEMA)@Au@TiO 2 @DOX NPs were able to provide enhanced contrast under T 1 - or T 2 -weighted magnetic resonance imaging (MRI). Results : The in vitro and in vivo anticancer experiments demonstrated the tumor was effectively inhibited with minimal side effects by the multifunctional NPs. Conclusions : As far as we know, this is the first presentation of four therapeutic methods into one nanomaterial, which will open up a new dimension for the design of combined treatment.

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“…NPs can acquire similar properties through the transfer of the phytochemicals on their surface during the capping process. For example, Ahmad et al (2020) have developed a mint-based method by which spherical NPs have been obtained with a size between 20 and 70 nm, probably due to the presence of alkaloids, terpenoids and phenolics in the Mentha arvensis ethanolic leaf extract (Ahmad et al, 2020 (He et al, 2017) were involved in TiO 2 NPs biosynthesis. In general, research has focused on Angiosperm plants while Plantae kingdom comprises also gymnosperms, pteridophytes (ferns), bryophytes (mosses) and macroalgae, and for other kind of NPs these organisms have given efficient results (Acharya and Sarkar, 2014;Bhor et al, 2014;Jha and Prasad, 2010;Momeni and Nabipour, 2015).…”

Section: Plant Species Involved In the Synthesis Of Tio 2 Npsmentioning

confidence: 99%

“…Broadly, NPs are formed through the action of biochemicals on metal ions provided by a precursor salt. In the case of TiO 2 NPs, the precursor can be represented by titanium tetraisopropoxide (Landage et al, 2020), metatitanic acid (Alavi and Karimi, 2018), titanium oxysulfate (Subhapriya and Gomathipriya, 2018) or bulk forms of TiO 2 (He et al, 2017). If we go further, agrowastes or organic matter waste may represent a sustainable source of biomolecules for the green synthesis of NPs (Zamani et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Green synthesized titanium dioxide nanoparticles and their future applications in biomedicine, agriculture and industry

Miu

Dinischiotu

2021

Rev. Biol. Biomed. Sci.

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In the green synthesis of titanium dioxide nanoparticles (TiO2 NPs) chemical reagents are replaced with biological extracts. Conventional methods used in the manufacture of TiO2 NPs raise environmental issues as they use harmful chemicals and spend a high amount of energy. At a laboratory scale, biologically synthesized titanium dioxide nanoparticles (bio-TiO2 NPs) proved to be a suitable alternative to the chemically synthesized ones. The biological activity of NPs is mainly determined by their shape, size and crystalline structure. However, these characteristics are hardly controlled when natural sources of reagents are used and so bio-TiO2 NPs did not reach an advanced technology readiness level. In this paper, we reviewed the majority of the available studies referring to bio-TiO2 NPs. Our aim is to briefly present the efficiency of biochemicals from different living organisms in producing TiO2 nano-scale particles as well as the benefits bio-TiO2 NPs would bring to the biomedical, agricultural and industrial sectors. Finally, based on the available data we discuss the sustainability of bio-TiO2 NPs referring to their possible environmental, economic and societal impacts.

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<i>In vitro</i> cytotoxicity of biosynthesized titanium dioxide nanoparticles in human prostate cancer cell lines

Cited by 26 publications

References 18 publications

Appraisal of Comparative Therapeutic Potential of Undoped and Nitrogen-Doped Titanium Dioxide Nanoparticles

Appraisal of Comparative Therapeutic Potential of Undoped and Nitrogen-Doped Titanium Dioxide Nanoparticles

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Green synthesized titanium dioxide nanoparticles and their future applications in biomedicine, agriculture and industry

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<i>In vitro</i> cytotoxicity of biosynthesized titanium dioxide nanoparticles in human prostate cancer cell lines

Cited by 26 publications

References 18 publications

Appraisal of Comparative Therapeutic Potential of Undoped and Nitrogen-Doped Titanium Dioxide Nanoparticles

Appraisal of Comparative Therapeutic Potential of Undoped and Nitrogen-Doped Titanium Dioxide Nanoparticles

Zwitterionic Polymer-Gated Au@TiO2 Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Green synthesized titanium dioxide nanoparticles and their future applications in biomedicine, agriculture and industry

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Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy