<i>In Vitro</i> Screening of &#945;-Amylase Inhibition by Selected Terpenes from Essential Oils

Abstract

Purpose: To assess some terpenes from herbal products for possible inhibitory effects on serum α-amylase in order to ascertain their potential usefulness in the prevention and/or treatment of diabetes Type 2. Methods: Solutions of terpenes (citral, eukalyptol, β-pinene, myrcene, eugenol and terpineol)

Chemical Profiling and Discrimination of Essential Oils from Six Ferula Species Using GC Analyses Coupled with Chemometrics and Evaluation of Their Antioxidant and Enzyme Inhibitory Potential

“…4-Terpineol as well as α-pinene, which predominate the essential oil of Fp, were previously reported to possess considerable α-amylase inhibitory activity [24]. Similarly, the potent α-amylase inhibitory potential is mainly due to the synergistic action between the different components, which is in accordance to different previously reported studies that confirmed the α-amylase inhibitory effect of different terpenes and different Ferula species such as F. gummosa essential oil [24,25]. [20].…”

“…Fp and Fv exhibited the most potent α-amylase inhibitory potential as evidenced by their pronounced inhibitory activity, which was equivalent to 2.61 and 1.40 mmol ACAE/g oil, respectively, in which ACAE is the acarbose equivalent, a potent α-amylase inhibitor ( Figure 5). 4-Terpineol as well as α-pinene, which predominate the essential oil of Fp, were previously reported to possess considerable α-amylase inhibitory activity [24]. Similarly, the potent α-amylase inhibitory potential is mainly due to the synergistic action between the different components, which is in accordance to different previously reported studies that confirmed the α-amylase inhibitory effect of different terpenes and different Ferula species such as F. gummosa essential oil [24,25].…”

Natural Monoterpenes: Much More than Only a Scent

“…Significant studies based on in vitro screening of α ‐amylase inhibition have revealed the promising activity of the terpenes found in various essential oils . Among the tested compounds are citral, eucalyptol, β ‐pinene, myrcene, eugenol and terpineol.…”

“…Among the tested compounds are citral, eucalyptol, β ‐pinene, myrcene, eugenol and terpineol. In the study, α ‐amylase activity was determined by standard methods using an automated analyzer. Herein, citral exhibited the highest inhibition percentage at lower inhibitor concentrations, while eugenol showed the lowest in the case of ultrasonic preparation of terpenes.…”

Microencapsulation of eucalyptol in polyethylene glycol and polycaprolactone using particles from gas-saturated solutions

“…Other in vitro studies also showed inhibitory properties of eucalyptol against carbohydrate digesting enzymes. 22,23 Despite the multiple pharmacological attributes of eucalyptol, its poor aqueous solubility, chemical instability and high volatility have restricted its oral administration for treatment of various metabolic diseases. When ingested, it is also easily metabolized by liver microsomal enzymes to its hydroxylated derivatives, 2ahydroxy-1,8-cineole and 3a-hxdroxy-1,8-cineole.…”