The differences in the composition of essential oils obtained from the aerial parts of six Ferula species viz., F. caratavica (Fc), F. kuchistanica (Fk), F. pseudoreoselinum (Fp), F. samarcandica (Fs), F. tenuisecta (Ft) and F. varia (Fv) were detected both qualitatively and quantitatively using GC-MS and GC-FID analyses. One hundred and six metabolites were identified that account for 92.1, 96.43, 87.43, 95.95, 92.90 and 89.48% of Fc, Fk, Fp, Fs, Ft and Fv whole essential oils, respectively. The data from the GC-MS analyses were subjected to unsupervised pattern recognition chemometric analysis utilizing principal component analysis (PCA) to improve the visualization of such differences among the six species. Fk and Ft are very closely related to each other and were gathered together in one cluster. The antioxidant potential was assessed in vitro using different assays including 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), cupric reducing antioxidant capacity (CUPRAC), ferric reducing power (FRAP) and phosphomolybdenum (PM) assays. Ft and Fp exhibited the most notable antioxidant properties as evidenced by their pronounced activities in most of the antioxidant assays performed, followed by Fc. Fk showed the most effective tyrosinase inhibitory potential, which was estimated as 119.67 mgKAE/g oil, while Fp exhibited the most potent α-amylase inhibitory potential, which was equivalent to 2.61 mmol ACAE/g oil. Thus, it was concluded that Ferula species could serve as a promising natural antioxidant drug that could be included in different products and spices to alleviate hyperglycemia and used as a natural ingredient in pharmaceutical cosmetics to counteract hyperpigmentation.

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Extraction of the sum of esters of the sesquiterpene alcohols from the aerial part of Ferula tenuisecta and purification of obtained extract were studied, allowing in following to get the final substance without green coloration. It was determined the optimum adsorbent – actuated coal and its amount for removing the green coloration of water-alcohol extract from used raw materials. It was found that for the purification of the bottoms of water-alcohol extract, five-fold treatment with extractive petrol in a volume ratio of water solution – solvent 2:1 is necessary, and for extraction esters from a purified water solution – three-fold extraction with ethyl acetate in a volume ratio of water solution – solvent 2:1. It was used a filler to effective drying the substance of Tenestrol. The microcrystalline cellulose in a weight ratio from 1:8 to 1:10 to the raw material was chosen as the optimum filler. Technology for obtain of substance of esters of sesquiterpene alcohols with estrogenic action from the aerial part of Ferula tenuisecta was developed and called “Tenestrol”. From this technology substance "Tenestrol" with yield of 3.8% by weight of the raw material is obtained, which contains not less 20% of the esters.