<i>In vitro</i> Transdermal Delivery of Metformin from a HPMC/ PVA Based TDS-patch at Different pH

Abstract

A transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a time-released dose of medication through the skin for treating systemic illnesses. Since early 1980s, this dosage form of therapeutic system (TTS) has been available in the pharmaceutical market. Such a system offers a variety of significant clinical benefits over AbstractIn order to evaluate the pHs effect on the transdermal drug delivery, HPMC/PVA based TDS-patch was prepared. In vitro transdermal dissolution was performed at 32 o C at different pHs. Comparatively higher release rate was found in case of pH 7.4 than those of others. pHs 5.4 and 8 showed almost the same release pattern. The release fashion was Higuchi type of diffusion controlled release. This result showed that neutral pH would accumulate the maximum drug from such a TDS patch, where the skin pH (around 5.4) does not support such a release. Sustained release of drug from such a patch prefers skin pH rather than neutral pH.

Transdermal delivery of antidiabetic drugs: formulation and delivery strategies

“…This study predicts that the kinetic profiles of such transdermal patches were influenced with pH and the maximum amount of drug will accumulate at neutral pH where the skin pH does not support such a release. The skin pH permits relatively sustained release of drug from HPMC polyvinyl alcohol based transdermal patches of Mf [75].…”

“…Continued )Transdermal patch containing Mf and metoprolol tartarate was developed for the management of diabetes mellitus associated with hypertension[73] Developed solid lipid nanoparticles using propylene glycol (solvent), polymethacrylic acid (polymer) and soya lecithin (lipid base), loaded in Methocel TM K100M transdermal patches[74] HPMC polyvinyl-alcohol-based transdermal patches of Mf were prepared[75] Transdermal system was prepared using combinations of a hydrophobic polymer, EC and hydrophilic polymer PVP Nanoparticles containing an antioxidant (quercetin) and hypoglycemic agent Vb were prepared. Prepared scaffold film of nanoparticles showed remarkably high thermoresponsivity, cell compatibility and ex vivo drug release behavior Abbreviations: BCS, biopharmaceutics classification system; EC, ethylcellulose; Gb, glibenclamide; Gc, gliclazide; Gm, glimepiride; Gp, glipizide; HPMC, hydroxypropyl methyl cellulose; log P, logarithm partition coefficient; MP, melting point; Mf, metformin; MW, molecular weight; PVP, polyvinylpyrrolidone; Pz, pioglitazone; Rg, repaglinide; t1/2, half-life; Vb, voglibose.www.drugdiscoverytoday.com 5…”

Injectable and thermally contractible hydroxypropyl methyl cellulose/Fe3O4 for magnetic hyperthermia ablation of tumors

“…1c and Movie S1, the HPMC-60%Fe 3 O 4 material could be smoothly injected using a small needle. The injectability of this material is attributed to the miscibility of HPMC and PVA, and their interaction could reduce the injection resistance of the magnetic particles [26,27]. The possible mechanisms for this phenomenon might involve secondary forces without covalent bonding [28].…”

Nanoclay Reinforced Ternary Blends Based on Biodegradable Polymers for Drug Delivery Application

“…In TDDS, the patch containing the drug is applied on the body which releases the drug slowly and helps to reduce the job of the attendant. The issues like overdosing and underdosing can be controlled with TDDS [ 1 ]. The transdermal drug delivery system makes use of transdermal patches which help to release the drug over an extended time, thus avoiding frequent dosing.…”