&lt;i&gt;In Vivo&lt;/i&gt; Antioxidant Activity of Different Fractions of &lt;i&gt;Indigofera Barberi&lt;/i&gt; Against Paracetamol-induced Toxicity in Rats

Aminabee, Shaik; Atmakuri, Lakshmana Rao; Eswaraiah, M. Chinna

doi:10.4274/tjps.galenos.2018.30306

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…According to our results, it was evident that compounds 2a and 2b were highly superior to compounds 1a , 1b and silymarin in reducing MDA levels. In addition, levels of GSH of all tested compounds, regardless of the substituents, were as significantly high as silymarin when compared to the hepatotoxicity group, proving the ability of all compounds to reduce the oxidative stress caused by the reactive oxygen species [ 59 , 60 ]. Consistent damage to hepatocytes, as a consequence of free radical formation, triggers the recruitment of pro-inflammatory and pro-fibrotic cytokines, ultimately leading to fibrosis [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

The hepatoprotective effect of 4-phenyltetrahydroquinolines on carbon tetrachloride induced hepatotoxicity in rats through autophagy inhibition

Abdelgalil,

Elhammamy,

Ragab

et al. 2024

Biol Res

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Background The liver serves as a metabolic hub within the human body, playing a crucial role in various essential functions, such as detoxification, nutrient metabolism, and hormone regulation. Therefore, protecting the liver against endogenous and exogenous insults has become a primary focus in medical research. Consequently, the potential hepatoprotective properties of multiple 4-phenyltetrahydroquinolines inspired us to thoroughly study the influence of four specially designed and synthesized derivatives on carbon tetrachloride (CCl4)-induced liver injury in rats. Methods and results Seventy-seven Wistar albino male rats weighing 140 ± 18 g were divided into eleven groups to investigate both the toxicity profile and the hepatoprotective potential of 4-phenyltetrahydroquinolines. An in-vivo hepatotoxicity model was conducted using CCl4 (1 ml/kg body weight, a 1:1 v/v mixture with corn oil, i.p.) every 72 h for 14 days. The concurrent treatment of rats with our newly synthesized compounds (each at a dose of 25 mg/kg body weight, suspended in 0.5% CMC, p.o.) every 24 h effectively lowered transaminases, preserved liver tissue integrity, and mitigated oxidative stress and inflammation. Moreover, the histopathological examination of liver tissues revealed a significant reduction in liver fibrosis, which was further supported by the immunohistochemical analysis of α-SMA. Additionally, the expression of the apoptotic genes BAX and BCL2 was monitored using real-time PCR, which showed a significant decrease in liver apoptosis. Further investigations unveiled the ability of the compounds to significantly decrease the expression of autophagy-related proteins, Beclin-1 and LC3B, consequently inhibiting autophagy. Finally, our computer-assisted simulation dockingonfirmed the obtained experimental activities. Conclusion Our findings suggest that derivatives of 4-phenyltetrahydroquinoline demonstrate hepatoprotective properties in CCl4-induced liver damage and fibrosis in rats. The potential mechanism of action may be due to the inhibition of autophagy in liver cells.

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Section: Discussionmentioning

confidence: 99%

The hepatoprotective effect of 4-phenyltetrahydroquinolines on carbon tetrachloride induced hepatotoxicity in rats through autophagy inhibition

Abdelgalil,

Elhammamy,

Ragab

et al. 2024

Biol Res

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Effects of Boron and NaCl on Antioxidant Defence Mechanisms in Duckweeds (Spirodela polyrhiza L.)

Parlak¹

2021

Pakistan J. of Biological Sciences

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Computational Identification of Selected Bioactive Compounds From Cedrus Deodara as Inhibitors Against Sars-Cov-2 Main Protease: A Pharmacoinformatics Study

Shaik,

Atmakuri

2024

IND. DRU.

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Amid the ongoing Covid-19 pandemic, the quest for potent antiviral treatments intensifies. This study focuses on the potential of bioactive compounds from the Himalayan cedar Cedrus deodara against the SARS-CoV-2 virus. Specifically targeting the main protease (MPro) and spike protein, the study employs docking trials and molecular dynamics simulations. Compounds such as quercetin, dihydrodehydrodiconiferyl alcohol, and cedeodarin exhibit notable binding affinity, surpassing the reference drug favipiravir. Molecular dynamics simulations affirm the stability of these complexes throughout the simulation period. While these findings underscore promising interactions, it is crucial to emphasize the need for further research and experimental validation to fully explore the therapeutic capabilities of C. deodara in combatting Covid-19.

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<i>In Vivo</i> Antioxidant Activity of Different Fractions of <i>Indigofera Barberi</i> Against Paracetamol-induced Toxicity in Rats

Cited by 3 publications

References 10 publications

The hepatoprotective effect of 4-phenyltetrahydroquinolines on carbon tetrachloride induced hepatotoxicity in rats through autophagy inhibition

The hepatoprotective effect of 4-phenyltetrahydroquinolines on carbon tetrachloride induced hepatotoxicity in rats through autophagy inhibition

Effects of Boron and NaCl on Antioxidant Defence Mechanisms in Duckweeds (Spirodela polyrhiza L.)

Computational Identification of Selected Bioactive Compounds From Cedrus Deodara as Inhibitors Against Sars-Cov-2 Main Protease: A Pharmacoinformatics Study

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