&lt;i&gt;In vivo&lt;/i&gt; Reflectance Confocal Microscopy for Skin Imaging in Melasma

Funasaka, Yoko; Mayumi, Nobuko; Asayama, Sachiko; Takayama, Ryoko; Kosaka, M; Kato, Tokue; Kawana, Seiji

doi:10.1272/jnms.80.172

Cited by 5 publications

(5 citation statements)

References 3 publications

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“…Given RCM's correlation with histopathological findings of melasma, it is more precise than Wood's lamp classification of melasma subtypes 4,53,96,100,101 . Previous studies assessing the precision by which Wood's light and RCM could classify melasma depth found no significant correlations between the two techniques.…”

Section: Melasmamentioning

confidence: 95%

“…This technique has evaluated a wide range of inflammatory, neoplastic, and melanocytic skin disorders. It may offer an alternative to invasive skin biopsies in the future 53,95,96 …”

Section: Melasmamentioning

confidence: 99%

“…It may offer an alternative to invasive skin biopsies in the future. 53,95,96 RCM provides precise identification of melanocytes, pigmented keratinocytes, and melanophages in melasma lesions because melanin works as an endogenous contrast agent in pigmented lesions and generates a high dispersion of light. 35,97,98 RCM allows the practitioner to see how these components are distributed within the skin.…”

Section: Dermoscopymentioning

confidence: 99%

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Diagnostic tools for hyperpigmentation disorders in skin of color: An updated review

Pagan

Mitchell

Yousif

et al. 2022

Dermatological Reviews

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Hyperpigmentation disorders are highly prevalent and disproportionately affect patients with skin of color. Studies suggest that over 65% of Black or African American patients haveexperienced at least one episode of hyperpigmentation due to skin damage or irritation. Notably, melasma and postinflammatory hyperpigmentation are the two most common forms of dyschromia in patients with skin of color. Additionally, otherconditionssuch as lichen planus and erythema dyschromicum perstans can have a more severe presentation and significant morbidity in this patient population. Thus, hyperpigmentation disorders can benefit greatly from prompt and accurate diagnosis that results in more precise management. In this review, we present the most updated information regarding dermoscopy, reflectance confocal, and conventional light microscopy in the diagnosis of hyperpigmentation disorders in skin of color. In addition, we summarize the benefits and pitfalls of some of these techniques, with a special emphasis on their accuracy and potential to assess favorable treatment outcomes. We also describe recent studies that have compared these diagnostic techniques across many disorders of hyperpigmentation and the practical findings that can be applied to everyday practice. We recognize that the cost of equipment, clinician training, and device availability are all critical factors when choosing the ideal diagnostic tool and provide varied approaches to improve accuracy. Today, diagnosing and treating hyperpigmentation skin conditions has become easier through technological advances.More reliable, noninvasive techniques such as dermoscopy and reflectance confocal microscopy show promise as adjuncts to guide laser and light therapies and monitor treatment response in dermatology clinics and clinical trials.

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Section: Melasmamentioning

confidence: 95%

“…This technique has evaluated a wide range of inflammatory, neoplastic, and melanocytic skin disorders. It may offer an alternative to invasive skin biopsies in the future 53,95,96 …”

Section: Melasmamentioning

confidence: 99%

Section: Dermoscopymentioning

confidence: 99%

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Diagnostic tools for hyperpigmentation disorders in skin of color: An updated review

Pagan

Mitchell

Yousif

et al. 2022

Dermatological Reviews

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“…According to the RCM findings, melasma is classified into two main types, the epidermal and mixed type, which is in full agreement with histology. [ 16 17 ] In Liu et al .’s study[ 16 ] in which they examined 200 melasma cases with RCM, 143 (71.5%) of 200 cases were classified as epidermal and the remaining 57 (28.5%) were classified as mixed-type. In epidermal-type melasma lesions, more intense melanin density is observed in the epidermis compared to the surrounding normal skin.…”

Section: In Vivo Reflectance Confocal Microscopy Findings Of Melasmamentioning

confidence: 99%

The Use of In Vivo Reflectance Confocal Microscopy for the Diagnosis and Classification of Melasma

Duman,

Yaman,

Oraloğlu

et al. 2023

Indian Journal of Dermatology

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“…Therefore, a noninvasive imaging device that can scan skin tissue in vivo would be preferred for skin disease diagnosis. Thus far, clinical skin imaging has been performed with traditional optical imaging methods, including dermoscopy, laser Doppler, optical coherence tomography, and confocal and two-photon microscopy ( Arrasmith et al., 2010 ; Calzavara-Pinton et al., 2008 ; Funasaka et al., 2013 ; Ghita et al., 2016 ; Li et al., 2005 ). However, the thickness of the skin varies throughout the body, ranging from ∼0.5 mm to 4 mm ( James et al., 2016 ), and these optical imaging technologies do not have sufficient penetration depths ( Figure 1 a).…”

Section: Introductionmentioning

confidence: 99%

Seeing through the Skin: Photoacoustic Tomography of Skin Vasculature and Beyond

Humayun

Vienneau

et al. 2021

JID Innovations

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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<i>In vivo</i> Reflectance Confocal Microscopy for Skin Imaging in Melasma

Cited by 5 publications

References 3 publications

Diagnostic tools for hyperpigmentation disorders in skin of color: An updated review

Diagnostic tools for hyperpigmentation disorders in skin of color: An updated review

The Use of In Vivo Reflectance Confocal Microscopy for the Diagnosis and Classification of Melasma

Seeing through the Skin: Photoacoustic Tomography of Skin Vasculature and Beyond

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