Seeing through the Skin: Photoacoustic Tomography of Skin Vasculature and Beyond

Li, Daiwei; Humayun, Lucas; Vienneau, Emelina; Vu, Tri; Yao, Junjie

doi:10.1016/j.xjidi.2021.100039

Cited by 41 publications

(43 citation statements)

References 166 publications

(204 reference statements)

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“…[ 81 ] OAM can cover all layers composing the human skin and has been shown to represent a valuable tool to visualize psoriasis and eczema [ 13 ] or burns and other wounds. [ 82 ]…”

Section: Discussionmentioning

confidence: 99%

Broadband Model‐Based Optoacoustic Mesoscopy Enables Deep‐Tissue Imaging beyond the Acoustic Diffraction Limit

Hofmann

Rebling

et al. 2022

Laser & Photonics Reviews

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Optoacoustic mesoscopy (OAM) retrieves anatomical and functional contrast in vivo at depths not resolvable with optical microscopy. Recent progress on reconstruction algorithms have further advanced its imaging performance to provide high lateral resolution ultimately limited by acoustic diffraction. In this work, a new broadband model‐based OAM (MB‐OAM) framework efficiently exploiting scanning symmetries for an enhanced performance is presented. By capitalizing on the large detection bandwidth of a spherical polyvinylidene difluoride film while accurately accounting for its spatial impulse response, the new approach significantly outperforms standard OAM implementations in terms of contrast and resolution, as validated by functional in vivo experiments in mice and human volunteers. Furthermore, L1‐norm regularization enables resolving structures separated by less than the theoretical diffraction‐limited resolution. This unique label‐free angiographic performance demonstrates the general applicability of MB‐OAM as a super‐resolution deep‐tissue imaging method capable of breaking through the limits imposed by acoustic diffraction.

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“…[ 81 ] OAM can cover all layers composing the human skin and has been shown to represent a valuable tool to visualize psoriasis and eczema [ 13 ] or burns and other wounds. [ 82 ]…”

Section: Discussionmentioning

confidence: 99%

Broadband Model‐Based Optoacoustic Mesoscopy Enables Deep‐Tissue Imaging beyond the Acoustic Diffraction Limit

Hofmann

Rebling

et al. 2022

Laser & Photonics Reviews

View full text Add to dashboard Cite

show abstract

“…For example, in a salivary gland stimulation challenge conducted in mouse models, a decrease in sO 2 change between measurements taken before and after salivary stimulation post-EBRT was associated with radiation-induced salivary gland toxicity in a murine model assessed with macroscopic PAI ( Figure 1B ) ( 60 ). Mesoscopic implementations of PAI can achieve ~20 μm in-plane resolution up to ~3 mm in depth for skin imaging ( 52 , 127 ), indicating potential for clinical skin toxicity assessment ( 128 ). Preliminary work on skin atopic dermatitis grading ( 61 ) showed that combining PAI mesoscopy-derived total blood volume, average vessel diameter, and ratio of low to high frequency signals gave a discriminating signature for atopic skin dermatitis grade ( Figure 1C ) ( 129 ).…”

Section: Potential Uses Of Photoacoustic Imaging In Radiotherapymentioning

confidence: 99%

“…With the introduction of exogenous contrast agents, it is also possible to directly report on tumor tissue pO 2 ( 51 ). Moreover, PAI is scalable for non-invasive assessment of single capillaries and even red blood cells ( 52 ) and can also be used to extract information on blood flow ( 53 ). PAI has thus been proposed for application in superficial tumors to improve: radiation dose delivery and scheduling; patient stratification; and therapy response and radiation side effects monitoring.…”

Section: Introductionmentioning

confidence: 99%

The Potential of Photoacoustic Imaging in Radiation Oncology

et al. 2022

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Radiotherapy is recognized globally as a mainstay of treatment in most solid tumors and is essential in both curative and palliative settings. Ionizing radiation is frequently combined with surgery, either preoperatively or postoperatively, and with systemic chemotherapy. Recent advances in imaging have enabled precise targeting of solid lesions yet substantial intratumoral heterogeneity means that treatment planning and monitoring remains a clinical challenge as therapy response can take weeks to manifest on conventional imaging and early indications of progression can be misleading. Photoacoustic imaging (PAI) is an emerging modality for molecular imaging of cancer, enabling non-invasive assessment of endogenous tissue chromophores with optical contrast at unprecedented spatio-temporal resolution. Preclinical studies in mouse models have shown that PAI could be used to assess response to radiotherapy and chemoradiotherapy based on changes in the tumor vascular architecture and blood oxygen saturation, which are closely linked to tumor hypoxia. Given the strong relationship between hypoxia and radio-resistance, PAI assessment of the tumor microenvironment has the potential to be applied longitudinally during radiotherapy to detect resistance at much earlier time-points than currently achieved by size measurements and tailor treatments based on tumor oxygen availability and vascular heterogeneity. Here, we review the current state-of-the-art in PAI in the context of radiotherapy research. Based on these studies, we identify promising applications of PAI in radiation oncology and discuss the future potential and outstanding challenges in the development of translational PAI biomarkers of early response to radiotherapy.

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“…Although most melanomas are pigmented, around 5–10% of cutaneous melanomas are amelanotic, which may cause delayed detection and worse prognosis ( Chen and Sebaratnam, 2021 ; Chuchvara et al, 2021 ). From dermoscopy through reflectance confocal microscopy (RCM) to histology, this condition emphasizes difficulties in the diagnosis of amelanotic melanoma ( Li et al, 2021 ; Rasmussen et al, 2021 ; Williams et al, 2021 ).…”

Section: Dilemma Of Skin Cancer Theranosticsmentioning

confidence: 99%

Functionalization of Nanomaterials for Skin Cancer Theranostics

Zhang

Zhu

Hou

et al. 2022

Front. Bioeng. Biotechnol.

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Skin cancer has drawn attention for the increasing incident rates and high morbidity worldwide. Timely diagnosis and efficient treatment are of paramount importance for prompt and effective therapy. Thus, the development of novel skin cancer diagnosis and treatment strategies is of great significance for both fundamental research and clinical practice. Recently, the emerging field of nanotechnology has profoundly impact on early diagnosis and better treatment planning of skin cancer. In this review, we will discuss the current encouraging advances in functional nanomaterials for skin cancer theranostics. Challenges in the field and safety concerns of nanomaterials will also be discussed.

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Seeing through the Skin: Photoacoustic Tomography of Skin Vasculature and Beyond

Cited by 41 publications

References 166 publications

Broadband Model‐Based Optoacoustic Mesoscopy Enables Deep‐Tissue Imaging beyond the Acoustic Diffraction Limit

Broadband Model‐Based Optoacoustic Mesoscopy Enables Deep‐Tissue Imaging beyond the Acoustic Diffraction Limit

The Potential of Photoacoustic Imaging in Radiation Oncology

Functionalization of Nanomaterials for Skin Cancer Theranostics

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