&lt;i&gt;Jing Tong Yu Shu&lt;/i&gt;, a traditional Chinese medicine, suppresses IL-1β and IL-6 gene expressions in macrophages, and alleviates endometriosis

Tianchan, Zhang; Cong, Hongliang; Zhao, Shaofan; Qiao, Zhihua; Gu, Xumeng

doi:10.4314/tjpr.v16i12.20

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…TCM has been in use for the treatment of EM patients with infertility for a long time, such as combined spicebush, cyperus rotundus, herbal epimedii, dodder, angelica, and radix rehmanniae . Jing Tong Yu Shu, a TCM, also suppressed IL‐6 and IL‐1β expression in macrophages and alleviates EM . In the present study, CNYP administration significantly inhibited USP10 expression, ERK1/2 activation and proinflammatory factor secretions, and mediated apoptosis‐related protein expressions in ectopic endometrial stromal cells and surgically induced EM rats.…”

Section: Discussionsupporting

confidence: 62%

Cai's Neiyi Prescription promotes apoptosis and inhibits inflammation in endometrial stromal cells with endometriosis through inhibiting USP10

Zhu

Zhang

et al. 2018

Biotech and App Biochem

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To observe the effect of Cai's Neiyi Prescription (CNYP) on the apoptosis and inflammation in endometrial stromal cells with endometriosis (EM) both in vivo and in vitro, EM model rats and endometrial stromal cells were treated with CNYP and the level of USP10, p-ERK1/2, ERK1/2, and apoptosis-related protein as well as the levels of proinflammatory factors were measured by Western blotting and ELISA, respectively. Rats with surgically induced EM showed increased USP10 expression and ERK/2 activation. Intragastric administration of CNYP granule significantly inhibited EM-induced ERK1/2 activation and expression of USP10 and Bcl-2, but increased the expression of Bax and Caspase-7 in EM-induced rats. CNYP granule administration also inhibited EM-induced inflammation in rats. Moreover, the ectopic endometrial stromal cells isolated from EM patients demonstrated decreased ERK1/2 activation and expression of USP10 and Bcl-2 and increased expression of Bax and Caspase-7 after cultured in DMEM containing CNYP-medicated rat serum, which were reversed by USP10 overexpression and were enhanced by USP10 siRNA. USP10 overexpression also inhibited while USP10 siRNA enhanced the CNYP-induced inhibition of inflammation in ectopic endometrial stromal cells. Taken together, our results suggest that CNYP granule promotes apoptosis and inhibits inflammation in endometrial stromal cells with EM through inhibiting USP10. C 2018

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Section: Discussionsupporting

confidence: 62%

Cai's Neiyi Prescription promotes apoptosis and inhibits inflammation in endometrial stromal cells with endometriosis through inhibiting USP10

Zhu

Zhang

et al. 2018

Biotech and App Biochem

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“…It consists of eleven herbs: Angelica sinensis, Asarum sieboldii, Cortex cinnamom, Cornus officinalis, Corydalis yanhusuo, Dioscorea polystachya, Foeniculi Fructus, Faeces trogopterori, Paeonia lactiflora Pallas, Radix cyathulae , and Whitmania pigra Whitman . Zhang et al [ 200 ] reported that after four weeks of treatment with Jing Tong Yu Shu in endometriosis rat models, the volume of the ectopic endometrial tissue foci recorded a significant decrease. In addition, this traditional medicine significantly inhibited the secretion of IL-1β and IL-6 in the peritoneal fluid.…”

Section: Resultsmentioning

confidence: 99%

An Overview on the Conservative Management of Endometriosis from a Naturopathic Perspective: Phytochemicals and Medicinal Plants

Bălan

Moga

Dima

et al. 2021

Plants

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Background: Endometriosis is a chronic and debilitating disease, which affects millions of young women worldwide. Although medicine has incontestably evolved in the last years, there is no common ground regarding the early and accurate diagnosis of this condition, its pathogenic mechanisms, and curative treatment. Even though the spontaneous resolution of endometriosis is sometimes possible, recent reports suggested that it can be a progressive condition. It can associate chronic pelvic pain, vaginal bleeding, infertility, or malignant degenerescence. Conventional treatments could produce many side effects, and despite treatment, the symptoms may reappear. In recent years, experimental evidence suggested that plant-based medicine could exert beneficial effects on endometriosis and endometriosis-related symptoms. This study aims to highlight the pharmaceutical activity of phytochemicals and medicinal plants against endometriosis and to provide a source of information regarding the alternative treatment of this condition. Methods: For this review, we performed a research using PubMed, GoogleScholar, and CrossRef databases. We selected the articles published between January 2000 and July 2020, written in English. Results: We found 17 medicinal plants and 13 phytochemicals, which have demonstrated their beneficial effects against endometriosis. Several of their biological activities consist of antiangiogenic, anti-inflammatory effects, and oxidative-stress reduction. Conclusion: Medicinal herbs and their bioactive compounds exhibit antiangiogenic, antioxidant, sedative and pain-alleviating properties and the effects recorded until now encourage their use for the conservative management of endometriosis.

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“…Although surgical and hormonal treatments are applied as the common interventions, the unpleasant side effects limited the use of these interventions. Some medicinal plants were shown to be potential treatment for the disease [7]. Taoren-Quyu Decoction (TQD), which is composed of Prunus persica (L.) Batsch 10 gram, Salvia miltiorrhiza Bge.…”

Section: Introductionmentioning

confidence: 99%

Effect of Taoren-Quyu decoction on endometriosis in rats

Zheng¹

2021

Trop. J. Pharm Res

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Purpose: To study the effect of traditional Chinese Medicine formula Taoren-Quyu decoction (TQD) on endometriosis. Method: Fifty female Wistar rats were randomly separated into five groups (10 rats/group): normal control, model (untreated) group, positive control (danazol), 200 mg/kg/day (low dose) or 400 mg/kg/day (high dose). All rats were prepared into endometriosis except for normal control rats. TDQ groups rats were orally administered of TQD for 5 weeks. After treatment, the rats were sacrificed by cervical dislocation. The number of total endometriotic lesions were counted. Serum levels of cancer antigen 125 (CA-125), interleukin 13 (IL-13), interleukin 18 (IL-18) and peritoneal fluid tumor necrosis factoralpha (TNF-α) were measured by ELISA kits. Result: Compared with control rats, TQD reduced the number of total endometriotic lesions significantly (12.7 ± 1.2, p < 0.01), as well as serum levels of CA-125 (6.4 ± 1.2 U/mL), IL-18 (118.6 ± 7.4 pg/mL), IL13 (6.3 ± 0.8 pg/mL) and peritoneal fluid TNF-α (231.5 ± 11.7 pg/mL) (p < 0.01). Conclusion: The results reveal that TQD exerts anti-endometriotic effect in rats by inhibiting inflammatory factors. Therefore, TQD has potentials for use in the treatment of endometriosis.

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<i>Jing Tong Yu Shu</i>, a traditional Chinese medicine, suppresses IL-1β and IL-6 gene expressions in macrophages, and alleviates endometriosis

Cited by 3 publications

References 21 publications

Cai's Neiyi Prescription promotes apoptosis and inhibits inflammation in endometrial stromal cells with endometriosis through inhibiting USP10

Cai's Neiyi Prescription promotes apoptosis and inhibits inflammation in endometrial stromal cells with endometriosis through inhibiting USP10

An Overview on the Conservative Management of Endometriosis from a Naturopathic Perspective: Phytochemicals and Medicinal Plants

Effect of Taoren-Quyu decoction on endometriosis in rats

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