<i>Ludwigia octovalvis</i> (Jacq.) raven extract supplementation enhances muscle glycogen content and endurance exercise performance in mice

Abstract

Ludwigia octovalvis (Jacq.) raven extract supplementation enhances muscle 2 glycogen content and endurance exercise performance in mice 3 (n=8 per group) were orally administered LOE for 4 weeks at 0 (vehicle), 61.5 36 (LOE-1X) or 307.5 (LOE-5X) mg/kg/day. LOE supplementation was able to 37 dose-dependently increase endurance swimming time (P<0.0001) and decrease levels 38 of serum lactate (P=0.0022), ammonia (P<0.0001), creatine kinase (P<0.0001), blood 39 urea nitrogen (P<0.0001) and glucose utilization (P<0.0001) after acute exercise 40 challenge. The glycogen in gastrocnemius muscle also increased with LOE treatment 41 in a dose-dependent manner (P<0.0001). Biochemically, AST, ALT, LDH, CK, BUN, 42 creatinine and UA levels were decreased with LOE treatment. Our study shows that 43 4-week supplementation with LOE increases muscle glycogen content storage to 44 enhance exercise performance and anti-fatigue effects. 45 Yi

Chemical Characterization, Antilipidemic Effect and Anti-Obesity Activity of Ludwigia octovalvis in a Murine Model of Metabolic Syndrome

“…These compounds have been associated with the observed biological effects, which can act individually or synergistically through several mechanisms. Previous studies have indicated that certain compounds, such as gallic acid and ethyl gallate, could decrease lipid absorption from the diet by inhibiting pancreatic lipase [17], which influences lipid metabolism, and that this could explain the effects found in healthy mice [37], as well as the results in this study.…”

The Effects of Ergosta-7,9(11),22-trien-3β-ol from Antrodia camphorata on the Biochemical Profile and Exercise Performance of Mice

“…The stored form of glucose is glycogen, which mostly exists in the liver and muscle tissues. Liver and muscle tissues were excised after the mice were euthanized, weighed analyzed for glycogen content, as described previously [37]. The weights of the liver, kidney, heart, lung, muscle, epididymal fat pad (EFP), and brown adipose tissue (BAT) were recorded.…”

Ethyl acetate fraction of flavonoids from <i>Polygonum hydropiper L.</i> modulates pseudorabies virus-induced inflammation in RAW264.7 cells via the nuclear factor-kappa B and mitogen-activated protein kinase pathways

“…Flavonoids are the main effective components in this herb, and ingredients such as rutin, quercetin, hyperoside, quercitrin, galloyl quercitrin, quercitrin, kaempferol, anthraquinones, naphthoquinones, and sesquiterpenoids, have been identified in P. hydropiper L. [31]. Modern pharmacological studies report antitumor [39], antiviral [14,23], antioxidant [5], and anti-inflammatory effects [1,10] of the flavonoids from P. hydropiper L.. Crude extracts of P. hydropiper L. have been prepared through water, ethanol, or methanol extraction, but there are limited studies on the purification of the effective ingredients from P. hydropiper L. [47]. A crude ethanol extract of P. hydropiper L. had been previously purified in our lab via fractional extraction using petroleum ether, chloroform, ethyl acetate, and normal butanol.…”