<i>Morus alba</i> Enhanced Functional Recovery After Sciatic Nerve Crush Injury

Abstract

Problem statement: Traumatic nerve injury has been recognized as one of the problems commonly found in road traffic crashes. Therefore, searching for the effective substances for promoting the functional recovery of nerve after injury is in required. Accumulating lines of evidence show that free radicals generated after injury contribute the important role to retard functional recovery, thus the substance possessing anti-oxidant could facilitate functional recovery. Based on the effect of antioxidant to promote functional recovery of nerve after injury mentioned earlier, we hypothesized that Morus alba extract, a substance possessing anti-oxidant activity, should be able to facilitate the functional recovery of peripheral nerve after injury. Approach: To elucidate this issue, male Wistar rats, weighing 180-220 g, were orally given the aqueous extract of Morus alba at various doses ranging from 0.1, 1 and 10 mg kg −1 BW 5days before and 21 days after sciatic nerve injury.Motor, sensory and sensorimotor coordination were observed every 3 days for 3 weeks by using De Medinacelli method, foot reflex withdrawal test and rotarod test, respectively. Results: The low dose of the extract significantly improved both sensory and motor functions after crush injury. Although sensory function recovers more sooner than the motor function, it fails to show full recovery within weeks. Thus, the present study demonstrates the potential of M. alba extract to enhance functional recovery after crush injury. Conclusion: In conclusion, Morus alba may serve as functional food to promote nerve recovery after injury. However, further studies about the possible active ingredient (s) and underlying mechanism (s) are required.

Effect of Azadirachta indica flower extract on functional recovery of sciatic nerve crush injury in rat models of DM

“…Each rat received four training trials per day with an interval trial time of 10 min. Although the accelerating mode was more suitable to evaluate the sensorimotor coordination of rats (15,27), the poor motor function of the rats of the present study following surgery prevented the use of that specific mode. A previous study by Abada et al (28) demonstrated that the best rotarod performance of rats is achieved when the speed used on the test day is faster than that on the training days.…”

“…Therefore, the identification of a plant exhibiting both antioxidative and hypoglycemic properties would be beneficial for the treatment of patients with diabetes. Numerous studies have reported that plants containing antioxidants could promote nerve recovery following a crush injury (15)(16)(17).…”

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“…The antioxidant (Mucimapura et al, 2010;Balasubramanyam et al, 2006;Akbari-Asbagh et al, 2010;Al-Attar, 2010a;2010b) effects of V. amygdalina extract account for the energy-lowering effects of the extract that produced the calming of the body.…”

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