&lt;i&gt;Nigella sativa&lt;/i&gt; improves the carbon tetrachloride-induced lung damage in rats through repression of erk/akt pathway

Aslan, Abdullah Nabi; Boydak, Didem; Can, Muhammed İsmail; Kuloğlu, Tuncay

doi:10.3329/bjp.v10i3.23486

Cited by 11 publications

(3 citation statements)

References 23 publications

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“…This lends credence to the mechanistic schematic we have depicted in Figure 3; as is shown in that diagram, several components of BC act to inhibit COX1/COX2 activity, which is indeed necessary to produce PGE2. In yet another study, researchers discovered that levels of erk are decreased upon N. sativa treatment of damaged rat lungs [49]. The erk repression discussed here is supported by our mechanistic analysis, which has found that kaempferol, a component of N. sativa, inhibits ERK1/2 activity.…”

Section: Discussionsupporting

confidence: 79%

Anti-allergic and anti-inflammatory activities of black cumin extracts in in vitro and in vivo model systems

Shaheen

Azam

Anwar

et al. 2021

Preprint

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Black cumin (Nigella sativa) is a widely used ingredient of traditional medicine for its broad-spectrum pharmacological actions, including anti-allergic, bronchial asthma, and anti-inflammatory properties. We sought to evaluate BC extracts' efficacy for their anti-allergic and anti-inflammatory properties using a comprehensive in vitro, in vivo, and silico experimental setup. To investigate whether BC extract has anti-inflammatory, anti-allergic, and analgesic therapeutic potentials in vitro and in vivo. The activity of BC was assessed through anti-allergic activity on rat basophilic leukemia-2H3 cell line, anti-inflammatory activity on J774.1A cell line, anti-inflammatory activity by carrageenan-induced rat paw edema, analgesic activity by acetic acid-induced writhing test, and ingenuity analysis of the BC extracts in inflammation control. BC exerted potent anti-allergic activity by inhibiting antigen-induced degranulation. An anti-inflammatory effect is shown by inhibiting TNF-α pro-duction. The acetic acid-induced writhing test shown a dose-dependent reduction of writhing number following BC administration. Rat paw edema test shown the dose-dependent reduction of paw edema volume following BC administration. Ingenuity Pathway Analysis (IPA) suggested BC extracts containing ferulic acid, p-coumaric acid, kaempferol, and quercetin can inhibit inflammation. This study suggests that bioactive compounds in BC extract act as an anti-allergic and anti-inflammatory agent by regulating several downstream and upstream inflammation pathways.

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Section: Discussionsupporting

confidence: 79%

Anti-allergic and anti-inflammatory activities of black cumin extracts in in vitro and in vivo model systems

Shaheen

Azam

Anwar

et al. 2021

Preprint

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“…They reported that the catalase activities of brain and liver tissues decreased in the D‐galactose group compared to the control group, but they found a meaningful increase of catalase enzyme activity in the EA + D‐gal group. Aslan, Boydak, Can, and Kuloglu (2015) investigated whether the consumption of Nigella sativa is a protecting role against CCl 4 ‐induced lung damage in rats. They concluded that the MDA amount interestingly decreased in black seed + CCl 4 group in comparison to the CCl 4 group.…”

Section: Discussionmentioning

confidence: 99%

The preventive effect of ellagic acid on brain damage in rats via regulating of Nrf‐2, NF‐kB and apoptotic pathway

et al. 2020

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The aim of this study was to investigate the neuroprotective role of ellagic acid (EA) on CCl4‐induced brain injury in rats. In this study, the rats were divided into four groups. Groups: (1) Control group; (2) EA group; (3) CCl4 group; (4) EA + CCl4 group. In brain tissue, tumor necrosis factor‐α (TNF‐α), nuclear factor kappa b (NF‐kB), cyclooxygenase‐2 (COX‐2), nuclear erythroid related factor 2 (Nrf‐2), cysteine‐aspartic acid protease (caspase‐3), VEGF (vascular endothelial growth factor) and B‐cell lymphoma‐2 (bcl‐2) protein expression levels were analyzed by western blotting. MDA (malondialdehyde), catalase enzyme activity (CAT) and glutathione (GSH) analysis were determined by spectrophotometer. In our findings, EA ameliorated Nrf‐2 and caspase‐3 protein expression levels, GSH and catalase activities, NF‐kB, TNF‐α, VEGF, Bcl‐2, COX‐2 protein expression levels and MDA levels in CCl4 intoxicated rats. These results suggest that EA demonstrated the neuroprotective effect on CCl4‐induced brain damage in rats. Practical applications Ellagic acid has different biological activities, these are; antioxidant, anti‐inflammatory, antidepressant, antifibrosis, anticancer, neuroprotective and hepatoprotective. For example it was reported that EA protects the cells against DNA injury induced by free radicals and it can prevent the traumatic brain injury. These results obtained from this study reveals that EA has a protective effect against rat brain damage and it may be used as an alternative drugs for the brain injury treatment in future.

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“…1 These factors increase mortality rate and put the extra burden on the patient and thereby increasing the overall cost of the treatment. 2 Carbon tetrachloride (CCl 4 ), a synthetic halogenated and the highly lipid soluble molecule, is applied on various laboratory animal models to study the potential roles of an 4 but it also significantly affects the heart, 5 brain, 6 lung, 7 reproductive organs and most importantly in kidney. 8 The actual mechanism of CCl 4 in the kidney is yet not clear but it is described that the pathogenic pathway is depending onto free radical-mediated oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Fresh Bitter Melon Fruit (Momordica charantia) Attenuated Oxidative Stress, Fibrosis and Renal Injury in Carbon Tetrachloride Treated Rats

Sagor

Reza

Tabassum

et al. 2018

Dhaka Univ. J. Pharm. Sci

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Chemical or drug-induced kidney damage is increasing every year and the end-stage renal disease is becoming a burden for health care system of many countries. Oxidative stress may be a crucial pathway for the development of end-stage renal disease. Thus, natural antioxidant or plant-based therapy would be a better alternative to protect renal function against chemical-induced renal damage. To determine these aspects we evaluated renoprotective effects of M. charantia in carbon tetrachloride administered rats. A 10% w/w mixture of fresh fruits of M. charantia was given with the chow food every day to CCl4 treated rats. After fourteen days, all animals were sacrificed and the kidneys were examined to observe the possible protective effects of M. charantia against CCl4 induced toxicity. The CCl4 treated rats showed increased oxidative stress parameters and decreased antioxidant enzymes activities. Supplementation of 10% w/w M. charantia fruits in CCl4 administered rats prevented the oxidative stress and restored the antioxidant enzymes activities. M. charantia fruits supplementation also prevented the rise of uric acid and creatinine concentration in plasma of CCl4 treated rats. Furthermore, histological studies showed that supplementation of 10% w/w M. charantia fruits prevented the collagen deposition, immune cell migration and iron deposition in kidney sections of CCl4 treated rats. The results of this study revealed that the fruits of M. charantia may protect oxidative stress-mediated damage in kidneys due to CCl4 administration, which is mediated probably via the restoration of anti-oxidant enzyme functions.

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<i>Nigella sativa</i> improves the carbon tetrachloride-induced lung damage in rats through repression of erk/akt pathway

Cited by 11 publications

References 23 publications

Anti-allergic and anti-inflammatory activities of black cumin extracts in in vitro and in vivo model systems

Anti-allergic and anti-inflammatory activities of black cumin extracts in in vitro and in vivo model systems

The preventive effect of ellagic acid on brain damage in rats via regulating of Nrf‐2, NF‐kB and apoptotic pathway

Fresh Bitter Melon Fruit (Momordica charantia) Attenuated Oxidative Stress, Fibrosis and Renal Injury in Carbon Tetrachloride Treated Rats

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