&lt;p&gt;Association among genetic polymorphisms of GSTP1, HO-1, and SOD-3 and chronic obstructive pulmonary disease susceptibility&lt;/p&gt;

Souza

et al. 2020

IJMS

The coronavirus disease of 2019 (COVID-19) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global pandemic with increasing incidence and mortality rates. Recent evidence based on the cytokine profiles of severe COVID-19 cases suggests an overstimulation of macrophages and monocytes associated with reduced T-cell abundance (lymphopenia) in patients infected with SARS-CoV-2. The SARS-CoV-2 open reading frame 3 a (ORF3a) protein was found to bind to the human HMOX1 protein at a high confidence through high-throughput screening experiments. The HMOX1 pathway can inhibit platelet aggregation, and can have anti-thrombotic and anti-inflammatory properties, amongst others, all of which are critical medical conditions observed in COVID-19 patients. Here, we review the potential of modulating the HMOX1-ORF3a nexus to regulate the innate immune response for therapeutic benefits in COVID-19 patients. We also review other potential treatment strategies and suggest novel synthetic and natural compounds that may have the potential for future development in clinic.

Section: Role Of Hmox1 In Thrombosis Fibrinolysis and Sepsismentioning

confidence: 99%

Section: Role Of Hmox1 In Thrombosis Fibrinolysis and Sepsismentioning

confidence: 99%

The HMOX1 Pathway as a Promising Target for the Treatment and Prevention of SARS-CoV-2 of 2019 (COVID-19)

Souza

et al. 2020

IJMS

“…From this study, it may be concluded that Ho-1 gene polymorphism has an important role in coPd. Yamada et al (52), du et al (78) and Zhou et al (79) also demonstrated that the L (GT)n allele frequency in patients with coPd was significantly higher compared with that in the control group.…”

Section: Association Between Ho-1 Gene Polymorphism and Clinical Diseasesmentioning

confidence: 94%

Association between HO‑1 gene promoter polymorphisms and diseases (Review)

Sun

Wang

et al. 2021

Mol Med Rep

Heme oxygenase-1 (Ho-1) is an inducible cytoprotective enzyme that degrades heme into free iron, carbon monoxide and biliverdin, which is then rapidly converted into bilirubin. These degradation products serve an important role in the regulation of inflammation, oxidative stress and apoptosis. While the expression level of Ho-1 is typically low in most cells, it may be highly expressed when induced by a variety of stimulating factors, a process that contributes to the regulation of cell homeostasis. in the 5'-non-coding region of the Ho-1 gene, there are two polymorphic sites, namely the (GT)n dinucleotide and T(-413)a single nucleotide polymorphism sites, which regulate the transcriptional activity of Ho-1. These polymorphisms have been shown to be closely associated with the occurrence and progression of numerous diseases, including cardiovascular, pulmonary, liver and kidney, various types of cancer and viral diseases. The present article reviews the progress that has been made in research on the association between the two types of polymorphisms and these diseases, which is expected to provide novel strategies for the diagnosis, treatment and prognosis of various diseases. Contents1. introduction 2. regulation of Ho-1 expression 3. Ho-1 promoter polymorphism 4. association between Ho-1 gene polymorphism and clinical diseases 5. conclusions and prospects

“…In continuous research in recent years, the polymorphism of the HO-1 gene promoter has been found to have a certain correlation with a growing number of disease states. In a deal of past clinical work, the association between (GT)n repeat length polymorphism and the risk of various diseases has been reported, including respiratory system diseases [ 104 ], malignant tumor [ 105 , 106 ], and others. The epidemiological correlation may be used as a risk index to evaluate the susceptibility and prognosis of the disease, and also be beneficial to the study of disease pathogenesis and potential therapeutic targets.…”

Section: Possible Assessment Markers For Diseasementioning

confidence: 99%

The non-canonical effects of heme oxygenase-1, a classical fighter against oxidative stress

et al. 2021

Redox Biology

The role of heme oxygenase-1 in resisting oxidative stress and cell protection has always been a hot research topic. With the continuous deepening of research, in addition to directly regulating redox by catalyzing the degradation of heme, HO-1 protein also participates in the gene expression level in a great diversity of methods, thereby initiating cell defense. Particularly the non-canonical nuclear-localized HO-1 and HO-1 protein interactions play the role of a warrior against oxidative stress. Besides, HO-1 may be a promising marker for disease prediction and detection in many clinical trials. Especially for malignant diseases, there may be new advances in the treatment of HO-1 by regulating abnormal ROS and metabolic signaling. The purpose of this review is to systematically sort out and describe several aspects of research to facilitate further detailed mechanism research and clinical application promotion in the future.