<p>Association of <em>Apolipoprotein E</em> Gene Polymorphism with Ischemic Stroke in Coronary Heart Disease Patients Treated with Medium-intensity Statins</p>

Abstract

Objective To study the association of apolipoprotein E ( APOE ) gene polymorphism with ischemic stroke (IS) in coronary heart disease (CHD) patients treated with medium-intensity statins. Methods The retrospective study was performed on 662 samples including 169 CHD subjects complicated with IS, 296 subjects with CHD, and 197 control subjects. The APOE gene was obtained from case files. Univariable and multivariable logistic regression analyses were utilized to recognize the possible risks of CHD and IS. Results The frequency of ε3-ε4 genotype was increased in the CHD group ( p =0.013) and CHD-IS group ( p =0.001), the frequency of ε4 allele was also increased in the CHD group ( p =0.047) and the CHD-IS group ( p =0.009) compared with control group. ε3-ε4 genotype was the independent risk for CHD and CHD-IS after adjusting for traditional risk factors with adjusted odds ratio (AOR) 2.210, 95%CI: 1.263–3.867, p =0.005) and (AOR 2.794, 95%CI: 1.539–5.072, p =0.002). The ε4 allele was also significantly associated with CHD (AOR 2.126, 95%CI: 1.265–3.575,=0.004) and CHD-IS (AOR 2.740, 95%CI: 1.569–4.784, p =0.001). Conclusion These results demonstrated that ε4 allele influenced the development of CHD with or without IS, especially for the genotype of ε3-ε4. CHD patients carrying the ε3-ε4 genotype and the ε4 allele were significantly associated with the incidence of IS, even if medium-intensity statins had been used.

Single-Nucleotide Polymorphisms in Oxidative Stress-Related Genes and the Risk of a Stroke in a Polish Population—A Preliminary Study

“…Ischemic stroke, the most common type of a stroke, is a complex multifactorial disease caused by the interaction between environmental risk factors and genetic predisposition [ 17 , 18 , 19 ]. To date, numerous case-control studies have confirmed the association between SNPs and a stroke [ 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. Ischemic strokes occurring in the carotid circulation are the most common type of an ischemic stroke, accounting for approximately 85% of all cases [ 27 ].…”

Alcohol Drinking, Apolipoprotein Polymorphisms and the Risk of Cardiovascular Diseases

“…Beneficial effects of statin treatment were found in ApoE4 carriers by most authors [ 183 - 186 ]. Mixed or negative effects were found in a few studies [ 187 , 188 ]. ApoE genotype had no significant effect on the response to treatment with atorvastatin in patients with heterozygous familial hypercholesterolemia [ 188 ].…”

Association of Apolipoprotein E Gene Polymorphism with Lipid Profile and Ischemic Stroke Risk in Type 2 Diabetes Mellitus Patients

“…The ε 4 allele was referred to be an important risk factor for cerebral infarction [ 14 – 16 ]. E3/E4 genotype and the ε 4 allele were related to the incidence of IS among coronary heart disease patients receiving statin therapy [ 38 ]. On the contrary, we found that ApoE allele distribution has no association with IS risk in T2DM subjects.…”