&lt;p&gt;Associations Between Gestational Diabetes Mellitus Risk and Folate Status in Early Pregnancy and &lt;em&gt;MTHFR&lt;/em&gt; C677T Polymorphisms in Chinese Women&lt;/p&gt;

Liu, Peng Ju; Liu, Yanping; Ma, Liangkun; Yao, Ai Min; Chen, Xiao Yan; Hou, Yi; Wu, Li; Xia, Liang

doi:10.2147/dmso.s250279

Cited by 29 publications

(56 citation statements)

References 34 publications

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“…In the end, 17 studies met the selection criteria, 5 of which (Cheng et al., 2019; Huang et al., 2019; Li, Li, et al., 2019; Zhu et al., 2016) used FA supplement or intake instead of folate level as the standard of maternal folate status (Table S1). Therefore, we only included the remaining 12 studies (Barzilay et al., 2018; Berglund et al., 2016; Guven & Cetinkaya, 2005; Idzior‐Waluś et al., 2008; Krishnaveni et al., 2009; Lai et al., 2018; Li, Hou, et al., 2019; Liu et al., 2020; Seghieri et al., 2003; Sukumar et al., 2016; Tarim et al., 2004; Xie et al., 2019) for qualitative and quantitative (meta‐analysis) synthesis.…”

Section: Resultsmentioning

confidence: 99%

Association between maternal folate status and gestational diabetes mellitus

Yang

Cai

Zhang

2021

Food Science & Nutrition

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Studies on the association between maternal folate status and gestational diabetes mellitus (GDM) have yielded inconsistent results. This meta‐analysis was performed to determine whether there may exist some association between maternal folate status and GDM. Unrestricted searches of PubMed, Web of Science, Cochrane, and Embase were conducted. All relevant studies on the association between maternal folat status and GDM risk were screened. The standardized mean difference (SMD) with 95% CIs was used to determine the association between maternal folate and GDM. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random‐effects models to assess the impact of maternal folate status on GDM risk. 12 studies were included. The overall data revealed that compared with the non‐GDM group, women with GDM had higher level of folate (SMD 0.41, 95% CI 0.07 to 0.21, I2 = 17.2%) in second or third trimester. We also found that maternal high folate status may be associated with increased risk of GDM (OR 2.16, 95% CI 1.70 to 2.74, I2 = 0.0%). Compared with non‐GDM group, women with GDM are prone to higher folate level. Moreover, high maternal folate status may predict a higher risk of GDM. As the number of included studies was limited, further large population studies are needed in the future.

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Section: Resultsmentioning

confidence: 99%

Association between maternal folate status and gestational diabetes mellitus

Yang

Cai

Zhang

2021

Food Science & Nutrition

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“… 36 These polymorphisms are widely studied during metabolic disease, 37–39 and has been associated with insulin resistance, 40 and an increased risk of developing cardiovascular disease, 41 , 42 T2D 43 and major depressive disorder 44 in South African populations. Recently, the MTHFR rs1801133 polymorphism has been linked to higher folate concentrations in early pregnancy and an increased risk of developing GDM in Chinese women, 45 and has been associated with GDM-related pregnancy complications such as gestational hypertension, pre-eclampsia and intrauterine fetal growth restriction. 46 , 47 …”

Section: Introductionmentioning

confidence: 99%

No Association Between ADIPOQ or MTHFR Polymorphisms and Gestational Diabetes Mellitus in South African Women

Dias¹,

Adam²,

Rheeder³

2021

DMSO

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Purpose Gestational diabetes mellitus (GDM) is a growing public health concern. GDM affects approximately 14% of pregnancies globally, and without effective treatment, is associated with short- and long-term complications in mother and child. Lower serum adiponectin (ADIPOQ) concentrations and aberrant DNA methylation have been reported during GDM. The aim of this study was to investigate the association between the ADIPOQ −11377C>G and −11391G>A, and methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphisms and GDM in a population of black South African women. Materials and Methods DNA was isolated from the peripheral blood of 447 pregnant women with (n=116) or without (n=331) GDM, where after ADIPOQ (rs266729 and rs17300539) and MTHFR (rs1801133) polymorphisms were genotyped using TaqMan Quantitative Real-Time PCR analysis. Results Women with GDM had a higher body mass index (p=0.012), were more insulin resistant (p<0.001) and had lower adiponectin levels (p=0.013) compared to pregnant women with normoglycemia. Genotypic, dominant and recessive genetic models showed no association between ADIPOQ rs266729 and rs17300539 and MTHFR rs1801133 polymorphisms and GDM. Intriguingly, the risk G allele of ADIPOQ rs266729 was associated with higher fasting glucose and insulin concentrations, while the T allele in MTHFR rs1801133 was associated with higher fasting insulin concentrations only. Conclusion ADIPOQ rs266729 and rs17300539 and MTHFR rs1801133 polymorphisms are not associated with GDM in a population of black South African women. These findings suggest that these single nucleotide polymorphisms (SNPs) do not individually increase GDM risk in the African population. However, the role of these SNPs in possible gene-gene or gene-environment interactions remain to be established.

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“…Out of the 9 studies included in this review, 6 supported the association between increased folic acid intake and the development of GDM during pregnancy, 2 showed an inverse relation between folate supplementation and GDM risk, while just one found no association at all when several factors were adjusted for, including genetics [21]. However, in the last study, the sample size was small compared to others (n = 336), and it focused on one ethnicity in China.…”

Section: Main Findingsmentioning

confidence: 87%

“…Supplementation Finally, one cohort study found no statistical significance between GDM and folic acid supplementation after adjustment for rs1801133 polymorphisms [21]. Higher RBC folate, partly caused by MTHFR 677C  T, may be associated with increased GDM risk, even in early pregnancy; participants with the TT genotype had the highest RBC folate concentrations.…”

Section: Studies Showing No Relation Between the Risk Of Gdm And Famentioning

confidence: 98%

Gestational Diabetes Mellitus and Folic Acid Supplementation in Pregnant Women: A Systematic Review

Farah¹,

Albaini²,

Jallad³

2021

JDM

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Background: Gestational diabetes mellitus (GDM) is a common pregnancy disorder screened for between the 24 th and 28 th weeks of gestation using oral glucose tolerance test. GDM has maternal and fetal health implications. Objective: To assess the relation between folic acid supplementation in pregnant women and the risk of developing GDM. Search Strategy: The search employed topic-based strategies designed for each database in June 2020. Databases searched were Pubmed, Cochrane Library, Embase and Lebanese American University online database. Selection Criteria: Studies eligible were those targeting the association of GDM development and folic acid supplementation, including pregnant women who have developed GDM and pregnant women who were on folic acid supplementation and developed GDM. Both interventional and observational studies were included. Data Collection and Analysis: Two reviewers extracted the data independently. A third reviewer checked the data for consistency and clarity. Data extracted included the sample characteristics, sample size and outcomes. Cohen's κ was used to assess agreement between reviewers. All tools and processes were piloted prior to use. Risk of bias was assessed using the Newcastle-Ottawa Scale. Data was presented in a tabulated form. Main Results: Six studies showed a proportional relation between folic acid intake and GDM, two reported a protective effect, and one cohort found no association. Conclusion: The inconsistent results made the formulation of a definitive conclusion difficult. Hence, larger studies are needed.

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<p>Associations Between Gestational Diabetes Mellitus Risk and Folate Status in Early Pregnancy and <em>MTHFR</em> C677T Polymorphisms in Chinese Women</p>

Cited by 29 publications

References 34 publications

Association between maternal folate status and gestational diabetes mellitus

Association between maternal folate status and gestational diabetes mellitus

No Association Between ADIPOQ or MTHFR Polymorphisms and Gestational Diabetes Mellitus in South African Women

Gestational Diabetes Mellitus and Folic Acid Supplementation in Pregnant Women: A Systematic Review

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