&lt;p&gt;Blue Mussel (&lt;em&gt;Mytilus edulis&lt;/em&gt;) Water Extract Ameliorates Inflammatory Responses and Oxidative Stress on Osteoarthritis in Obese Rats&lt;/p&gt;

Chang, Heng-Wei; Sudirman, Sabri; Yen, Yu-Wen; Mao, Chien-Feng; Ong, Alan Darmasaputra; Kong, Zwe‐Ling

doi:10.2147/jpr.s244372

Cited by 12 publications

(7 citation statements)

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“…(2020) found that a water extract of blue mussels decreased LPO and reduced inflammation in rats with osteoarthritis. However, the levels of the SOD enzyme were not correlated with the amount of P. canaliculus in the diet, which is not consistent with the literature (Chang et al., 2020; Freitas et al., 2020), as animals were not receiving any toxins that would trigger the production of oxygen species. As a result, SOD was not increased.…”

Section: Discussionmentioning

confidence: 99%

“…It is considered a significant food source rich in various nutrients such as protein, lipids, and carbohydrates (Santhanam, 2014) and can have a therapeutic effect in treating several diseases. Recently, several studies have focused on the value of marine life and its use as a potent food source (Sargent, 1997), as well as some of its biologically active ingredients that could be used as anticancer agents (Aldairi et al., 2018; Khurshid & Pye, 2018), cardioprotective agents (Matanjun et al., 2010), and antioxidant source (Chang et al., 2020). In this regard, molluscs are the most noticeable group of marine organisms due to their associated health benefits (Khan & Liu, 2019); therefore, its daily consumption would be beneficial in preventing many illnesses (Khan & Liu, 2019; Nongmaithem et al., 2018).…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant and antithrombotic effects of green mussels ( Perna canaliculus ) in rats

et al. 2021

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In the past decade, the use of marine mussels as seafood is being more popular. They considered being a rich source of various nutritional bioactive compounds that aroused the scientific community's interest. This study investigated the antioxidant and the antithrombotic consequences on Sprague‐Dawley male rats after adding dried New Zealand mussel Perna canaliculus in their diet. The biochemical, hematological and histopathological changes were also observed. Forty rats were divided into four groups according to the amount of dried mussels in their diet, in addition to a control group that consumed a basal diet only. Group 1 consumed 25% dried mussels in its basal diet; Group 2 consumed 35% dried mussels in its basal diet, and Group 3 was consumed 45% dried mussels in its basal diet. The biochemical parameters showed improvements in liver function. Interestingly, the lipid profile decreased, especially the low‐density lipoprotein cholesterol (LDL‐C) levels which were reduced significantly in Group 3 (p < .01). These observations were accompanied by a decrease in iron levels significantly as the amount of dried mussels increased (p < .01). Furthermore, the noticed changes in the hematological profile prove that there is an increase in antithrombotic activity. Dried mussels had potent antioxidant effects in the liver as shown by increased lipid peroxide (p < .05), reduced glutathione (p < .05), and glutathione peroxidase (GSH‐Px; p < .05). Additionally, antioxidant activity in the kidney was shown to increase through GSH‐Px activity (p < .01). In conclusion, these results indicate that consuming dried mussels resulted in improved biochemical and antioxidants activities and could be used as an antithrombotic agent.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant and antithrombotic effects of green mussels ( Perna canaliculus ) in rats

et al. 2021

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“…Epidemiological studies of abnormal blood lipid metabolism and OA have found that elevated serum triglycerides are risk factors for the progression of OA. 81 Davies-Tuck et al reported that triglycerides are associated with the prevalence of BMLs in asymptomatic middle-aged women for more than two years. The results of this study provide a basis for the hypothesis that vascular pathological changes are involved in the progression of OA.…”

Section: Obesity-related Biological Processes and Oamentioning

confidence: 99%

Adiponectin, May Be a Potential Protective Factor for Obesity-Related Osteoarthritis

Jiang¹,

Yu²,

Li³

et al. 2022

DMSO

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Osteoarthritis (OA) is the most common joint disease in elderly individuals and seriously affects quality of life. OA has often been thought to be caused by body weight load, but studies have increasingly shown that OA is an inflammation-mediated metabolic disease. The current existing evidence suggests that OA is associated with obesity-related chronic inflammation as well as abnormal lipid metabolism in obesity, such as fatty acids (FA) and triglycerides. Adiponectin, a cytokine secreted by adipose tissue, can affect the progression of OA by regulating obesity-related inflammatory factors. However, the specific molecular mechanism has not been fully elucidated. According to previous research, adiponectin can promote the metabolism of FA and triglycerides, which indicates that it is a potential protective factor for OA through many mechanisms. This article aims to review the mechanisms of chronic inflammation, FA and triglycerides in OA, as well as the potential mechanisms of adiponectin in regulating chronic inflammation and promoting FA and triglyceride metabolism. Therefore, adiponectin may have a protective effect on obesity-related OA, which could provide new insight into adiponectin and the related mechanisms in OA.

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“…OA can be induced by direct damage of knee joint cartilage by application of monosodium iodoacetate (MIA model) or other harmful agents. 71 , 72 The other models are based on creating knee instability by destabilization of the medial meniscus (DMM model) through transsection of the medial anterior meniscotibial ligament (MAMTL) which fixes the medial meniscus at the tibial plateau 73 or by transsection of the medial collateral ligament (MCL) together with removal of the medial meniscus (MCL-MMx model), transsection of the medial meniscus (medial meniscus transection: MMT model) 71 , 73 , 74 , of the ACL (ACLT model) 75 , 76 or combinations of them. 76 Novel models based on joint cartilage overloading by high impact or cyclic overloading (inducing non-invasively posttraumatic joint injury leading to posttraumatic OA [PTOA]) have also been proposed.…”

Section: In Vitro and In Vivo Disease Models For Elucidation Of Oa Thmentioning

confidence: 99%

Experimental Therapeutics for the Treatment of Osteoarthritis

Schulze‐Tanzil

2021

JEP

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Osteoarthritis (OA) therapy remains a large challenge since no causative treatment options are so far available. Despite some main pathways contributing to OA are identified its pathogenesis is still rudimentary understood. A plethora of therapeutically promising agents are currently tested in experimental OA research to find an opportunity to reverse OA-associated joint damage and prevent its progression. Hence, this review aims to summarize novelly emerging experimental approaches for OA. Due to the diversity of strategies shown only main aspects could be summarized here including herbal medicines, nanoparticular compounds, growth factors, hormones, antibody-, cell-and extracellular vesicle (EV)-based approaches, optimized tools for joint viscosupplementation, genetic regulators such as si-or miRNAs and promising combinations. An abundant multitude of compounds obtained from plants, environmental, autologous or synthetic sources have been identified with anabolic, anti-inflammatory,-catabolic and anti-apoptotic properties. Some ubiquitous signaling pathways such as wingless and Integration site-1 (Wnt), Sirtuin, Tolllike receptor (TLR), mammalian target of rapamycin (mTOR), Nuclear Factor (NF)-κB and complement are involved in OA and addressed by them. Hyaluronan (HA) provided benefit in OA since many decades, and novel HA formulations have been developed now with higher HA content and long-term stability achieved by cross-linking suitable to be combined with other agents such as components from herbals or chemokines to attract regenerative cells. pH-or inflammation-sensitive nanoparticular compounds could serve as versatile slowrelease systems of active compounds, for example, miRNAs. Some light has been brought into the intimate regulatory network of small RNAs in the pathogenesis of OA which might be a novel avenue for OA therapy in future. Attraction of autologous regenerative cells by chemokines and exosome-based treatment strategies could also innovate OA therapy.

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<p>Blue Mussel (<em>Mytilus edulis</em>) Water Extract Ameliorates Inflammatory Responses and Oxidative Stress on Osteoarthritis in Obese Rats</p>

Cited by 12 publications

References 60 publications

Antioxidant and antithrombotic effects of green mussels ( Perna canaliculus ) in rats

Antioxidant and antithrombotic effects of green mussels ( Perna canaliculus ) in rats

Adiponectin, May Be a Potential Protective Factor for Obesity-Related Osteoarthritis

Experimental Therapeutics for the Treatment of Osteoarthritis

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