<p>Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report</p>

Abstract

Lung cancer is the most common type of tumor, prone to contralateral lung, bone and brain metastasis. We report a 44-year-old woman diagnosed with lung cancer with multiple metastases in November 2015. Oral targeted drugs were initiated after the removal of brain metastases, and most lesions remained stable for 28 months. In March 2018, intracranial multiple metastases, as well as hydrocephalus accumulation in the third ventricle and lateral ventricles, and metastases in bone, adrenal gland, liver were noted. Hydrogen-gas monotherapy was started to control the tumor a month later. After 4 months, the size of multiple brain tumors was reduced significantly, and the amount of hydrocephalus in the third ventricle and lateral ventricles reduced significantly. After 1 year, all brain tumors had disappeared, and there were no significant changes in metastases in the liver and lung. These data show that, after standard treatments had failed, hydrogen-gas monotherapy elicited significant effective control of tumors (especially those in the brain), and survival time was lengthened.

Molecular Hydrogen as a Novel Antitumor Agent: Possible Mechanisms Underlying Gene Expression

“…Lung cancer is a very metastatic cancer, able to spread to the opposite lung, bone, and brain. Therefore, Chen et al also reported the results of a case study of a patient with a brain tumor that had multiple metastases from lung cancer [44]. The patient was treated with standard therapy that had no effects, and metastases transferred from the lungs to the brain, bones, adrenal glands, and liver.…”

“…After 4 months of monotherapy with H 2 gas (67%) for 2-6 h per day, the size of several brain tumors was significantly reduced, as was the amount of spinal fluid from hydrocephalus associated with the brain tumors. They reported that after one year, all brain tumors had disappeared and the increase in the size of the lung and liver cancers had been controlled [44].…”

Antitumor Activity of Protons and Molecular Hydrogen: Underlying Mechanisms

“…The experimental in vivo studies showed that H 2 inhalation could suppress glioblastoma tumor growth, prolonging the survival of mice with glioblastoma [ 56 ]. In a recent study, data show that, in a patient diagnosed with lung cancer with metastases, H 2 gas monotherapy was associated with a significant effective control of tumors [ 57 ]. The H + -related therapy for the treatment of malignant gliomas is a new therapeutic strategy.…”

A narrative review of hydrogen oncology: from real world survey to real world evidence

“…These data show that, after standard treatments had failed, hydrogen-gas monotherapy elicited significant effective control of tumors (especially those in the brain), and survival time was lengthened. 8 …”