<p>Cell membrane camouflaged nanoparticles: a new biomimetic platform for cancer photothermal therapy</p>

Abstract

Targeted drug delivery by nanoparticles (NPs) is an essential technique to achieve the ideal therapeutic effect for cancer. However, it requires large amounts of work to imitate the biomarkers on the surface of the cell membrane and cannot fully retain the bio-function and interactions among cells. Cell membranes have been studied to form biomimetic NPs to achieve functions like immune escape, targeted drug delivery, and immune modulation, which inherit the ability to interact with the in vivo environments. Currently, erythrocyte, leukocyte, mesenchymal stem cell, cancer cell and platelet have been applied in coating photothermal agents and anti-cancer drugs to achieve increased photothermal conversion efficiency and decreased side effects in cancer ablation. In this review, we discuss the recent development of cell membrane-coated NPs in the application of photothermal therapy and cancer targeting. The underlying biomarkers of cell membrane-coated nanoparticles (CMNPs) are discussed, and future research directions are suggested.

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

“…Au NPs encapsulated with the antitumour drug paclitaxel-coated by anti-EpCam antibodies-modified red blood cell membranes show increased cancer-targeting ability due to anti-EpCam antibodies. Paclitaxel can be released when the membrane is destroyed by the heat generated from the Au NPs under laser irradiation to yield the anticancer effect [ 134 ].…”

Therapeutic lipid-coated hybrid nanoparticles against bacterial infections

“…4). 71 Another point for consideration is that cell membrane extraction procedures are highly dependent on the cell source. 72 For instance, to obtain bioactive cell membrane from nucleusfree cells (e.g.…”

The Role of Natural Compounds and their Nanocarriers in the Treatment of CNS Inflammation

“…Particularly, endogenous cell-biomimetic NPs, also known as exosomes, can have their natural properties—inherited various endogenous molecules bound onto the bilayer of the biomimetic exosomes—and endogenous peptides, proteins, lipids, nucleic acids, and microRNAs included inside the exosomes. Owing to these features, biomimetic exosomes can exhibit specific targeting [ 248 ]. In a recent study, platelet membrane vesicles (PMVs) were exploited as a specific thrombus-targeting strategy for the treatment of ischemic stroke.…”