2020
DOI: 10.2147/ott.s264312
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<p>Cervical Cancer: Emerging Immune Landscape and Treatment</p>

Abstract: Immune cells are essential for defending the body's balance and have increasingly been implicated in controlling tumor growth. In cervical cancer (CC), the immune landscape is extensively connected with human papillomavirus (HPV) status. Recent insights from studies have revealed that as a result of infection with HPV, immune cell populations such as lymphocytes or monocytes change during carcinogenesis. Immune therapy, in particular checkpoint inhibitors, those targeting PD-1 or PD-L1, has shown promising eff… Show more

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Cited by 40 publications
(38 citation statements)
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“…As far as ovarian cancer is concerned, the mono-immunotherapy approach has hitherto not been indicated, because of controversial data. Particularly, single-agent Abs against CTLA-4, PD-1 or PD-L1 revealed modest results in epithelial ovarian cancer with median response rates (RR) less than 15% and a control of disease rate less than 50% [ 25 , 26 ]. On the contrary, combinations of immunotherapy with chemotherapy, anti-angiogenic agents or poly (ADP-ribose) polymerase (PARP) inhibitors have shown promising results in terms of ORR and median PFS [ 27 ].…”
Section: Resultsmentioning
confidence: 99%
“…As far as ovarian cancer is concerned, the mono-immunotherapy approach has hitherto not been indicated, because of controversial data. Particularly, single-agent Abs against CTLA-4, PD-1 or PD-L1 revealed modest results in epithelial ovarian cancer with median response rates (RR) less than 15% and a control of disease rate less than 50% [ 25 , 26 ]. On the contrary, combinations of immunotherapy with chemotherapy, anti-angiogenic agents or poly (ADP-ribose) polymerase (PARP) inhibitors have shown promising results in terms of ORR and median PFS [ 27 ].…”
Section: Resultsmentioning
confidence: 99%
“…II is mostly the immune attack against the virus itself, whereas CMI is the one against the pre-cancer lesion or tumor. Humoral immunity (HI) as mediated by B cells unexpectedly has adverse effect on the lesions of the cervix [4]. Hence I do not discuss HI further, here.…”
Section: Natural Regression Of Lsil the Genesis Of Hsil And The Genesis Of CC Explainedmentioning
confidence: 98%
“…The border between the two types of attacks is very thin, i.e., there may be overlaps. Innate immunity (II) and Cell Mediated immunity (CMI) are the dominant players of immunity against the HPV infection of the cervix [2,4]. II is mostly the immune attack against the virus itself, whereas CMI is the one against the pre-cancer lesion or tumor.…”
Section: Natural Regression Of Lsil the Genesis Of Hsil And The Genesis Of CC Explainedmentioning
confidence: 99%
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