<p>Clinical and instrumental evaluation of a new topical non-corticosteroid antifungal/anti-inflammatory/antiseborrheic combination cream for the treatment of mild-to-moderate facial seborrheic dermatitis</p>

Abstract

PurposeTopical agents play a key role in the management of facial seborrheic dermatitis (SD) by reducing inflammation and scale production. The aim of this open-label trial was to assess the efficacy and tolerability of a new non-corticosteroid, antifungal/anti-inflammatory/antiseborrheic cream containing piroctone olamine, stearyl glycyrrhetinate, and zinc PCA in the treatment of facial SD using clinical and instrumental evaluation.Patients and methodsTwenty adult subjects affected by mild-to-moderate inflamed facial SD were enrolled and instructed to apply the study cream twice daily for 60 days. Efficacy was evaluated at baseline, and at days 15, 30, and 60 by measuring the grade of desquamation, erythema, and pruritus using clinical evaluation, erythema-directed digital photography, colorimetry, and subject-completed Visual Analog Scale. Additionally, an Investigator Global Assessment (IGA) was assessed using a 5-point scale: excellent response (>80% improvement); good response (50%–80% improvement); mild response (<50% improvement); no response (no change); worsening.ResultsAfter 15 days, a statistically significant decrease from baseline was found in desquamation, erythema, colorimetric scores, and pruritus. At day 60, a significant further improvement for all evaluated parameters was recorded. Moreover, the IGA improved in 90% of patients, with an excellent response in 53% of cases. A good correlation was found between clinical and instrumental evaluations.ConclusionOur results indicate that the study facial cream represents an option to consider when dealing with mild-to-moderate SD, being effective, well-tolerated, and free of significant side effects, as confirmed by clinical and instrumental evaluation.

Exploring Anti-Fungal, Anti-Microbial and Anti-Inflammatory Properties of a Topical Non-Steroidal Barrier Cream in Face and Chest Seborrheic Dermatitis

“…Moreover, an important improvement efficacy for both face and chest in terms of IGA score was reported for all patients reaching a mild response at W1 (mean IGA score: 4.75 for face and 3.75 for chest) and excellent response at W2 (mean IGA score: 9.4 for face and 8.1 for chest). All these data are supported by Micali et al In fact, they have previously evaluated IGA score after 8 weeks of NSC treatment, reporting good and excellent responses in 29.5% and 53% of patients, respectively [26]. Beyond the clinical efficacy, here we have also deepened the antifungal property in vivo, based on previous evidence in which this characteristic of NSC had already been tested in an ex vivo model [27].…”

“…Our findings are in line with a recent study that reported NSC clinical efficacy up to 8 weeks, with a significant reduction of erythema, pruritus and desquamation. In particular, they observed a 90% reduction of VAS pruritus in the facial area, reporting 0.67 ± 1.05 cm after 2 weeks of NSC, with respect to 6.9 ± 1.68 cm at baseline [26]. Here, we observed an 85% reduction of VAS pruritus in the facial area, reporting 1.5 ± 0.70 cm after 2 weeks of NSC treatment with respect to 9.6 ± 0.14 cm at baseline.…”

Novel Non-Steroidal Facial Cream Demonstrates Antifungal and Anti-Inflammatory Properties in Ex Vivo Model for Seborrheic Dermatitis

“…Indeed, the efficacy of the novel NSFC tested in this study is supported by results from clinical trials. Here, NSFC demonstrated significant effects on desquamation, erythema, and pruritus in subjects with mild-to-moderately inflamed facial SEBD [20].…”

Facial Seborrheic Dermatitis in HIV-Seropositive Patients: Evaluation of the Efficacy and Safety of a Non-Steroidal Cream Containing Piroctone Olamine, Biosaccharide Gum-2 and Stearyl Glycyrrhetinate – A Case Series

“…Previous studies 10–12 have assessed this topical treatment in populations without HIV, but this case series provides specific information on the HIV-positive population group, which can be resistant to treatment.…”

“…In SD patients without HIV, various publications have shown the usefulness of a non-steroidal, antifungal, anti-inflammatory and antiseborrheic cream marketed under the name Nutradeica (ISDIN, Spain). 10–12 This combines several ingredients including piroctone olamine, which has antifungal properties; 10 , 13 the zinc salt of l-pyrrolidone carboxylate (zinc PCA), which has antifungal and anti-inflammatory properties; biosaccharide gum-2, which has anti-inflammatory and antifungal properties; and stearyl glycyrrhetinate, which has anti-inflammatory, antioxidant, and skin-soothing properties. 14 This topical treatment has previously been reported to accelerate recovery and prevent flare-ups.…”