&lt;p&gt;Coagulative biomarkers on admission to the ICU predict acute kidney injury and mortality in patients with septic shock caused by intra-abdominal infection&lt;/p&gt;

Xu, Zhipeng; Cheng, Baoli; Fu, Shuiqiao; Liu, Xu; Xie, Gary; Li, Zhongwang; Ji, Yun; Fu, Qinghui; Fang, Xiangming

doi:10.2147/idr.s218592

Cited by 30 publications

(32 citation statements)

References 47 publications

(37 reference statements)

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“…IAI is defined as an infection in the abdominal cavity, presenting with the clinical signs of local and systemic inflammation (pain, tenderness, fever, tachycardia and tachypnea) [ 31 , 32 ]. IAIs can be classified according to the time and severity of the infection [ 32 ].…”

Section: Methodsmentioning

confidence: 99%

Predictive value of immune cell counts and neutrophil-to-lymphocyte ratio for 28-day mortality in patients with sepsis caused by intra-abdominal infection

Liu

She

et al. 2021

Burns &Amp; Trauma

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Background The current study aimed to evaluate the value of immune cell counts and neutrophil-to-lymphocyte ratio (NLR) when attempting to predict 28-day mortality. Methods We conducted an observational retrospective study that included consecutive septic patients. Severity scores on the first day and peripheral circulating immune cell counts (at day 1, day 3, day 5 and day 7 of admission) were collected during each patient’s emergency intensive care unit stay. We assessed the associations of peripheral circulating immune cell counts and NLR with the severity of illness. The relationships between 28-day mortality and peripheral circulating immune cell counts and NLR with were evaluated using Cox proportional cause-specific hazards models. Results A total of 216 patients diagnosed with sepsis caused by IAI were enrolled. The lymphocyte counts (days 1, 3, 5 and 7) and monocyte counts (days 3, 5 and 7) were significantly lower in non-survivors (n = 72) than survivors (n = 144). The NLR values at each time point were significantly higher in non-survivors. The day 1 lymphocyte counts, as well as the monocyte counts, were significantly lower in the highest-scoring group, when stratified by the Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment scores, than in the other groups (p < 0.05). The day 1 NLR was significantly higher in the highest-scoring group than in the other groups (p < 0.05). The day 5 and day 7 lymphocyte counts, day 3 and day 7 monocyte counts and day 7 NLR were significant predictors of 28-day mortality in the Cox proportional hazards models (day 5 lymphocyte count: hazard ratio, 0.123 (95% CI, 0.055–0.279), p < 0.001; day 7 lymphocyte count: hazard ratio, 0.115 (95% CI, 0.052–0.254), p < 0.001; day 3 monocyte count: hazard ratio, 0.067 (95% CI, 0.005–0.861), p = 0.038; day 7 monocyte count: hazard ratio, 0.015 (95% CI, 0.001–0.158), p < 0.001; day 7 NLR: hazard ratio, 0.773 (95% CI, 0.659–0.905), p = 0.001). Conclusions The results showed that circulating lymphocytes and monocytes were dramatically decreased within 7 days in non-survivors following sepsis from an IAI. Lymphocyte counts, monocyte counts and NLR appeared to be associated with the severity of illness, and they may serve as independent predictors of 28-day mortality in septic patients with IAIs.

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Section: Methodsmentioning

confidence: 99%

Predictive value of immune cell counts and neutrophil-to-lymphocyte ratio for 28-day mortality in patients with sepsis caused by intra-abdominal infection

Liu

She

et al. 2021

Burns &Amp; Trauma

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“…Mortality associated with AKI is high (40-60%) and the short-and long-term outcomes in the form of chronic or end-stage renal disease are devastating (5). AKI develops in more than 45% of patients with septic shock (21). The mortality rate of our study patients was 59.5%.…”

Section: Discussionmentioning

confidence: 69%

“…Septic shock is associated with higher mortality compared to sepsis (1). Septic shock continues to account for 62% of general deaths and hospital mortality rates are above 40% (21). Mortality associated with AKI is high (40-60%) and the short-and long-term outcomes in the form of chronic or end-stage renal disease are devastating (5).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Effectiveness of Continuous Venovenous Hemodiafiltration Appli̇ed With Oxiris and AN69 Membranes in Patients With Septic Shock-Related Acute Kidney Injury

Kaçar¹,

Uzundere²,

Yüksel³

et al. 2020

Preprint

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Background and objectives: AN69 and Oxiris are filters used in continuous renal replacement therapy. In this study, we aimed to research the effects of these filters on blood cell counts, blood biochemistry, inflammation indicators, clinical status and mortality of patients diagnosed with septic shock-related acute kidney injury. Method: Between March 2019 and October 2019, 42 adult patients (Group 1: Oxiris (n = 21) or Group 2: AN69 (n=21)) with septic shock-related acute kidney injury and received continuous venovenous hemodiafiltration (CVVHDF) in the intensive care unit were included in the study and their results were prospectively observed and compared. The data at the begining of CVVHDF (pre-CVVHDF) and 24 hours after the onset of CVVHDF (post-CVVHDF) were recorded.Results: In the comparison of the pre- and post-CVVHDF values in Group 1, there was a statistically significant decrease detected in the procalcitonin (p = 0.04) and noradrenaline infusion rate (p = 0.02) levels. In terms of the other data there was no statistically significant difference between pre- and post-CVVHDF values in Group 1. In the comparison of the pre- and post-CVVHDF values in Group 2, there was a statistically significant decrease detected in the urea (p = 0.04), platelet count (p = 0.02) and procalcitonin (p = 0.002) levels. There was no statistically significant difference between pre- and post-CVVHDF values in terms of the other data in Group 2. There was no statistically significant difference between the groups in terms of mortality. Conclusions: CVVHDF with Oxiris filter causes a statistically significant decrease in noradrenaline infusion rate. Therefore, we think that the use of CVVHDF with Oxiris filter applied for septic shock-related acute kidney injury will save us time and increase the improvement in the treatment.

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“…Studies have found that D-dimer is related to renal insu ciency. [41][42][43][44][45][46][47][48][49][50] Yang et al found that the D-dimer level could predict AKI and mortality in ST-elevated myocardial infarction patients. 41 Guerchicoff also reached a similar conclusion.…”

Section: Discussionmentioning

confidence: 99%

Elevated preoperative D-dimer is associated with acute kidney injury after non-cardiac surgery

Yang

2021

Preprint

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aimed to analyze the relationship between preoperative D-dimer level and AKI following non-cardiac surgery.Method: This was a single-center retrospective cohort study for elective non-cardiac surgery from January 1, 2012, to December 31, 2018. The endpoint was the occurrence of AKI 7 days postoperatively in the hospital. The non-linear relationship was described using the generalized additive model. ROC and minimum P-value approach identified possible cut-off points. D-dimer's odds ratio as continuous, quantile, and dichotomous variables by various cut-off points for postoperative AKI were calculated in multivariate logistic regression models before and after propensity score weighting.Results: Of the 55439 surgery, 5.0% (2779 cases) suffered postoperative AKI. Non-linearity was found between D-dimer and postoperative AKI. The odds ratio for D-dimer before and after propensity score weighting was (≤ 0.380 µg/mL as reference, minimum P-value cut-off point) 1.35 (1.20-1.49), P < 0.001 and 1.25 (1.09-1.43), P = 0.001, respectively; (≤ 0.165 µg/mL as reference, ROC cut-off point) 1.24 (1.12-1.37), P < 0.001 and 1.18 (1.06-1.31), P = 0.002, respectively. Sensitivity analysis showed similar results. Heterogeneity subgroup analysis showed that patients with normal preoperative creatinine, hemoglobin level, and intraperitoneal surgery or more complex surgery seemed to be more vulnerable to elevated D-dimer.Conclusions: Preoperative D-dimer was significantly associated with postoperative AKI following non-cardiac surgery. The optimal cut-off point for preoperative D-dimer was 0.165 µg/mL by ROC approach and 0.38 µg/mL by minimum P-value approach.

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<p>Coagulative biomarkers on admission to the ICU predict acute kidney injury and mortality in patients with septic shock caused by intra-abdominal infection</p>

Cited by 30 publications

References 47 publications

Predictive value of immune cell counts and neutrophil-to-lymphocyte ratio for 28-day mortality in patients with sepsis caused by intra-abdominal infection

Predictive value of immune cell counts and neutrophil-to-lymphocyte ratio for 28-day mortality in patients with sepsis caused by intra-abdominal infection

Evaluation of the Effectiveness of Continuous Venovenous Hemodiafiltration Appli̇ed With Oxiris and AN69 Membranes in Patients With Septic Shock-Related Acute Kidney Injury

Elevated preoperative D-dimer is associated with acute kidney injury after non-cardiac surgery

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