<p>Combined Use of Mean Platelet Volume/Platelet Count Ratio and Platelet Distribution Width to Distinguish Between Patients with Nasopharyngeal Carcinoma, Those with Benign Tumors of the Nasopharynx, and Healthy Subjects</p>

Abstract

PurposeFor the diagnosis of nasopharyngeal carcinoma (NPC), reliable early indicators with sensitivity and specificity should be sought. This study evaluated the effect of the combined use of mean platelet volume/platelet count ratio (MPV/PC ratio) and platelet distribution width (PDW) for differential diagnosis of NPC. In this study, MPV/PC ratio was used for the first time to diagnostically evaluate NPC.Patients and methodsWe retrospectively analyzed various hematological indices of three subject groups (208, 185, and 162 patients with NPC, benign tumors of the nasopharynx, and healthy subjects, respectively) and evaluated the value of combined use of MPV/PC ratio and PDW for differential diagnosis of the three groups using the one-way analysis of variance.ResultsComparison of laboratory variables between the three groups showed a significant difference in MPV/PC ratio and PDW (P<0.001, all). The MPV/PC ratio in the NPC group was significantly lower than the other two groups (P<0.001); MPV/PC ratio also showed a statistically significant difference in different stages (P=0.034) and serosal invasions (P<0.001) of the NPC group. Receiver operating characteristic curve (ROC) analysis showed that areas under the curve (AUC) of either patients with benign tumors of the nasopharynx (AUCMPV/PCratio+PDW: 0.708) or healthy subjects (AUCMPV/PCratio+PDW: 0.909) were larger than those of MPV/PC ratio (AUCMPV/PCratio: 0.665, 0.869, respectively) and PDW (AUCPDW:0.614, 0.716, respectively) use alone (P<0.05, all).ConclusionMPV/PC ratio and PDW may be used as indexes of NPC. MPV/PC ratio combined with PDW could be considered as meaningful laboratory indexes for differential diagnosis of NPC, benign tumors of the nasopharynx, and healthy subjects. This finding could enhance the detection of NPC.

Low Preoperative Mean Platelet Volume/Platelet Count Ratio Indicates Worse Prognosis in Non-Metastatic Renal Cell Carcinoma

“…In our study, we found low MPV/PC ratios were associated with disease progression. Furthermore, the value of the MPV/PC ratio dropped stepwise from early to late stages, which is supported by Zhang et al [21]. Moreover, the C-index, which added the pathological stage as a known prognostic factor, showed that the AUC of the MPV/PC ratio in our study was 0.912 (p < 0.001).…”

“…On the other hand, substantial consumption of platelets happens in the case of inflammation or cancer. Overall, fluctuation of the PC may compromise its reliability for predicting disease progression [21].…”

“…However, in some occasions of neoplasm or tissue proliferation, such as nasal polyps, reduction in MPV was noted [32]. Due to the non-linear inverse relationship between MPV and PC, the MPV/PC ratio was preferentially proposed as a predictor in some studies [20,21,33]. Inagaki et al showed that the MPV/PC ratio was superior to MPV and PC alone for predicting lung cancer survival with multivariate analysis (MPV/PC ratio, HR = 1.668, p= 0.0008; MPV, HR = 1.381, p = 0.0121; PC, HR = 1.380, p = 0.0114) [20].…”

“…Furthermore, studies have shown a non-linear inverse relationship between MPV and PC, indicating that these two variables should be utilized as a ratio rather than being interpreted alone [19]. The diagnostic value of the MPV/PC ratio has been addressed in several studies [20,21], and our aim is to evaluate whether the MPV/PC ratio could serve as a prognostic factor in RCC patients.…”

The value of hemoglobin-to-red blood cell distribution width ratio (Hb/RDW), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for the diagnosis of nasopharyngeal cancer

“…In recent years, a significant progress has been made in the study of hematological markers for prognosis of different tumors. [ 7 , 8 ] The hematological indices have been widely used as indicators for prognosis, which are highly reproducible and cost-effective for clinical use. [ 9 , 10 ] This study aimed to investigate the clinical significance of hemoglobin-to-red cell distribution width ratio (Hb/RDW), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in the diagnosis of NPC.…”