&lt;p&gt;Comorbidities in multiple sclerosis—a plea for interdisciplinary collaboration to improve the quality of life of MS patients&lt;/p&gt;

Goischke, Hans-Klaus

doi:10.2147/dnnd.s204555

Cited by 8 publications

(4 citation statements)

References 132 publications

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“…МР-сигнал от недавно появившихся очагов определяется преимущественно отеком, а от давно существующих -глиозом. Таким образом, МРТ способна отражать полиморфность патологических изменений, наблюдаемых в ЦНС при РС [15].…”

Section: критерии магнитно-резонансных проявлений поражений при рассе...unclassified

Modern possibilities of MRI-based diagnosis of multiple sclerosis. Literature review

Degtyarev,

Zavadovskaya,

Kurazhov

et al. 2024

Bûll. sib. med.

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Multiple sclerosis remains the most common demyelinating disease of the central nervous system and ranks first among neurological diseases that lead to disability in young people. The most important diagnostic and prognostic marker, especially at an early stage of the disease, is magnetic resonance imaging (MRI), which currently remains the only method that allows to explore the entire central nervous system in vivo.The review presents literature data on modern achievements in MRI-based diagnosis of multiple sclerosis. Key attention is paid to such promising methods as assessment of brain and spinal cord atrophy, brain perfusion MRI, and diffusion tensor imaging. Implementation of these approaches in MRI can help solve the problem of early diagnosis of multiple sclerosis and determine more reliable markers of a response to ongoing therapy.

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Section: критерии магнитно-резонансных проявлений поражений при рассе...unclassified

Modern possibilities of MRI-based diagnosis of multiple sclerosis. Literature review

Degtyarev,

Zavadovskaya,

Kurazhov

et al. 2024

Bûll. sib. med.

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“…Similarly, an interdisciplinary approach is suggested to prevent the negative influence of co-morbidities on the quality of life of multiple sclerosis patients. Such cases are evident across the world ( Goischke, 2019 ). In cancer patients, drug-dose, mental care, pain care, social acceptance, medication access etc.…”

Section: Recent Advances and Lacuna In Interdisciplinary Researchmentioning

confidence: 99%

Future call for policy making to speed up interdisciplinarity between natural and social sciences and humanities in countries such as India

Das

Paital

2021

Heliyon

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Objectives Science is the erudite methodical systematic practises to study the structure and behaviour of natural objects and/or phenomena. It clearly unknot about the fact that science is a human (society) need based process that starts with social affairs, for example, need to exchange emotion and cognitive processes (psychology), feelings (literature), relation (sociology), money (economics) etc. Humanities are the use of approaches that are predominantly hypothetical but critical, and have a noteworthy historical component, and the methodical aspects distinguish it from the mainly experiential approaches of the science. The basic approaches in both remains the same that it needs a hypothesis, sound methodology, and interpretation of data. Human is the end user in both the cases. So, why only interdisciplinary research focused on the core subjects of science? For example, philosophy, deals with general and vital complications relating to matters including existence, knowledge, language, attitude, behaviour, values, ethics, reason, mind, peace and harmony in life which can be essentially a part of science (especially natural sciences and more particularly animals sciences such as zoology) or vice versa could be true. The current and future time will allow us to believe on such concept, is the main theme of the current article. Methods Articles from all published sources are considered for answering the objective that why not concentrating to speed up interdisciplinarity. Few tables and figure are reproduced or redrawn as per the need. And numerical data are collected to present the current status of the interdisciplinarity and the need of the pace it requires. Results It is noticed that number of research articles on interdisciplinarity in comparison to several core subject area in major databases including environmental biology are still negligible. Countries still need to inter-collaborate at interdisciplinary level for the development and benefit of human race. This needs to be done mainly at socio-economic, intercultural and scientific levels. Although numbers of steps are taken such as establishment of interdisciplinary institutes, introduction of interdisciplinary courses, interdisciplinary research and publication platforms in specialized dedicated journals, still concrete steps to introduce the course of interdisciplinarity at educational and professional level is wanting. Conclusion Therefore, policy on pace in interdisciplinarity across science and humanities is highly wanting especially in developing countries to fix several national and international issues. Present article deals with the current status and future prospective or policies required on interdisciplinarity.

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“…Depression as a comorbidity occurs in PwMS in up to 50% of cases [4][5][6][7][8]. Fatigue is present in 35-97% of people living with PwMS, severely affecting the quality of life [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Multiple sclerosis with comorbidity depression and its association with vitamin D deficiency in a narrative review of the current literature

Goischke

2023

Explor Neurosci

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Over the past decade, knowledge of the pathophysiology and immunology of multiple sclerosis (MS) and depression, and the complex links to vitamin D (VitD) balance, has increased rapidly. Both diseases are characterized by an imbalance of proinflammatory and antiinflammatory cytokines, increased serum neurofilament light chains (sNfLs), disruption of the blood-brain barrier (BBB), abolition of the physiological function of the various types of microglia (MG), decreased calcidiol-serum levels, and disorders of the gut microbiome in combination with hyperactivity of the hypothalamic-pituitary-adrenal (HPA)-axis/microbiome-gut-brain-axis characterized. In depression, stress initiates cellular and molecular changes in the brain via increased cortisol release in the HPA-axis. Microglial activation and neuronal damage as well as dysregulation of neuroplastic and neurotrophic factors complete the spectrum of pathological damage. It is shown that gut dysbiosis leads to increased gut permeability, which favors endotoxemia and ultimately paves the way to systemic inflammation. A VitD supplementation could restore the balance of microorganisms in the intestine and reduce the inflammatory processes at various levels. VitD promotes regulatory T cell (Treg) proliferation, inhibits the expression of T helper 1 (Th1) cells and Th17 immune cells, and inhibits proinflammatory interleukin-17 (IL-17). 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] reduces also the secretion of interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α). Increased calcitriol levels lead to a reduction in MG activation, oxidative stress, and lower BBB permeability. An early, permanent, daily sufficient VitD supplementation as an add-on therapy under control of the serum 25-hydroxyvitamin D [s25(OH)D] levels is an essential therapeutic tool to slow down the disability caused by MS and thereby primarily prevent or reduce the stress and subsequently the manifestation of depression. Through the future continuous measurement of the biomarkers serum neurofilament ligth chains and glial fibrillary acidic proteins as well as the s25(OH)D level in MS and comorbidity depression, future therapy successes or failures can be avoided.

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<p>Comorbidities in multiple sclerosis—a plea for interdisciplinary collaboration to improve the quality of life of MS patients</p>

Cited by 8 publications

References 132 publications

Modern possibilities of MRI-based diagnosis of multiple sclerosis. Literature review

Modern possibilities of MRI-based diagnosis of multiple sclerosis. Literature review

Future call for policy making to speed up interdisciplinarity between natural and social sciences and humanities in countries such as India

Multiple sclerosis with comorbidity depression and its association with vitamin D deficiency in a narrative review of the current literature

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