<p>Comparative Study Of Photodynamic Therapy With Riboflavin-Tryptophan Gel And 13% 5-Aminolevulinic Acid In The Treatment Of Mild To Moderate Acne Vulgaris</p>

Abstract

BackgroundNon-invasive photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) has been used as an alternative acne treatment for many years. Riboflavin and tryptophan are newly introduced photosensitizers.ObjectiveTo compare the efficacy of PDT with riboflavin-tryptophan (RT) gel with that of 13% ALA for the treatment of facial acne.MethodsWe performed a double-blind, split-face study of 37 subjects with mild to moderate facial acne vulgaris. RT gel was applied to half of the face, and 13% ALA was applied to the other half. Then, the whole face was irradiated using a blue light-emitting diode for 20 mins. Four treatment sessions were performed over a 4-week duration, at 1-week interval. The acne lesion counts and acne severity were assessed. Sebum secretion, Propionibacterium acne colonization, pore size, and skin texture were also evaluated.ResultsPDT with RT gel demonstrated good efficacy, non-inferior to ALA for acne treatment, with a significant reduction in acne lesion counts, severity grading, porphyrin, and sebum output. The pore size and skin texture were improved. Side-effects were minimal and well tolerated in all subjects.ConclusionPDT therapy with RT gel is an effective alternative treatment for acne vulgaris.

The Use of Lasers and Light Devices in Acne Management: An Update

“…Virtually painless treatment can be achieved by reducing the incubation time of 5% ALA and increasing the light dose, while maintaining satisfactory efficacy [101]. A range of concentrations and formulations of ALA were studied, with good results even for severe acne, including 0.5% liposome-encapsulated ALA [102], 1.5% ALA [103], 3.6% ALA [104,105], 10% ALA [106], and 13% ALA [107]. In a randomized, single-blinded, self-controlled trial of 180 Chinese patients with moderate-to-severe facial acne, treatment was administered using 5%, 10%, 15%, and 20% ALA [108].…”

“…However, one split-face study indicated that three treatments of PDT at 2-week intervals with 3%, 5%, or 10% ALA showed similar efficacy when photosensitizer protoporphyrin IX level in acne lesions was measured [110]. Several additional studies demonstrated the efficacy of PDT with other photosensitizers, including methyl aminolevulinate [111], riboflavin-tryptophan gel [107], chlorophyll-a with blue-red light [112], indole-3-acetic acid with green light [113], and indocyanine green with near infrared radiation [114]. In a randomized controlled trial of 46 patients with moderate inflammatory facial acne, the group with two sessions of 20% ALA-PDT 2 weeks apart had superior efficacy in reducing inflammatory acne lesions (reduction of 84% for ALA-PDT vs 74% for pharmacological therapies) and total acne lesions (reduction of 79% for ALA-PDT vs 67% for pharmacological therapies) than the group on oral doxycycline and adapalene gel combination therapy at the 12-week follow-up [115].…”

Nutritional Factors: Benefits in Glaucoma and Ophthalmologic Pathologies

“…With respect to the use of riboflavin in clinical research, Wangsuwan et al conducted research into the influence of riboflavin on acne vulgaris and concluded that vitamin B2 supplements significantly reduced the severity of acne lesions and improved the general skin health of patients in the study [ 248 ]. Baquerizo-Nole et al concluded that riboflavin reduces rosacea symptoms [ 249 ].…”

Tetraacetyl riboflavin derivative mediates caspase 3/7 activation via MAPK in A431 cells upon blue light influence

“…[4][5][6][7] Due to its phototoxic properties, it has been found applicable in photodynamic therapy (PDT). 8,9 However, exposure of Rfl to radiation in the UV-Vis range causes its gradual degradation, reducing its effectiveness as a potential sensitizer. Since in photodegradation processes a ribityl chain in a Rfl molecule is involved, hence an acetylated derivative of Rfl, in our study 3-methyl-tetraacetyl riboflavin (3MeTARF), could be more desirable in photodynamic oxidation processes, as it revealed to be the compound of high photostability.…”

“…It absorbs light in the UV–Vis range (200–700 nm) and is known to be a good singlet oxygen sensitizer, making it suitable as therapeutic agent in medical treatments, as well as factor in deactivation of many pollutants 1–3 and in photocatalysis 4–7 . Due to its phototoxic properties, it has been found applicable in photodynamic therapy (PDT) 8,9 …”