&lt;p&gt;Construction and validation of a seven-microRNA signature as a prognostic tool for lung squamous cell carcinoma&lt;/p&gt;

Gan, Zuhuan; Zou, Qiyun; Lin, Yan; Huang, Xiaoyuan; Huang, Zhong; Chen, Zhichao; Xu, Zihai; Lv, Yufeng

doi:10.2147/cmar.s191637

Cited by 11 publications

(5 citation statements)

References 36 publications

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“…This is the first report linking hsa_miR_5701 to neurological disease. It has already been linked to prognosis of patients with lung squamous cell carcinoma ( Gan et al, 2019 ), and it can inhibit the proliferation of cervical cancer cells ( Pulati et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

REPS1 as a Potential Biomarker in Alzheimer’s Disease and Vascular Dementia

Luo

Chen²,

Huang³

et al. 2022

Front. Aging Neurosci.

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Vascular dementia (VD) and Alzheimer’s disease (AD) are common types of dementia for which no curative therapies are known. In this study, we identified hub genes associated with AD and VD in order to explore new potential therapeutic targets. Genes differentially expressed in VD and AD in all three datasets (GSE122063, GSE132903, and GSE5281) were identified and used to construct a protein–protein interaction network. We identified 10 modules containing 427 module genes in AD and VD. Module genes showing an area under the diagnostic curve > 0.60 for AD or VD were used to construct a least absolute shrinkage and selection operator model and were entered into a support vector machine-recursive feature elimination algorithm, which identified REPS1 as a hub gene in AD and VD. Furthermore, REPS1 was associated with activation of pyruvate metabolism and inhibition of Ras signaling pathway. Module genes, together with differentially expressed microRNAs from the dataset GSE46579, were used to construct a regulatory network. REPS1 was predicted to bind to the microRNA hsa_miR_5701. Single-sample gene set enrichment analysis was used to explore immune cell infiltration, which suggested a negative correlation between REPS1 expression and infiltration by plasmacytoid dendritic cells in AD and VD. In conclusion, our results suggest core pathways involved in both AD and VD, and they identify REPS1 as a potential biomarker of both diseases. This protein may aid in early diagnosis, monitoring of treatment response, and even efforts to prevent these debilitating disorders.

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Section: Discussionmentioning

confidence: 99%

REPS1 as a Potential Biomarker in Alzheimer’s Disease and Vascular Dementia

Luo

Chen²,

Huang³

et al. 2022

Front. Aging Neurosci.

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“…We confirmed that the overexpression of POSTN can be identified as the target to predict shorter survival times in LUSC. In addition, has-miR-30e-3p was downregulated in LUSC tissues, which was proved to be strongly related to staging, poor survival, and differentiation [ 47 – 50 ]. However, there is no evidence suggesting that has-mir-144-3p and has-mir-30e-3p regulate POSTN expression in LUAD.…”

Section: Discussionmentioning

confidence: 99%

miRNAs-mediated overexpression of Periostin is correlated with poor prognosis and immune infiltration in lung squamous cell carcinoma

Chen

Oliver

2022

Aging

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Lung cancer is one of the most common malignancies with a high mortality rate worldwide. POSTN has been shown to be strongly correlated with the poor prognosis of lung cancer patients. However, the function and mechanism of action of POSTN in lung cancer remain unclear. Here, we carried out a pan-cancer analysis to assess the clinical prognostic value of POSTN based on the TCGA, TIMER, Oncomine, Kaplan-Meier, and UALCAN databases. We found that upregulated POSTN can be a promising biomarker to predict the prognosis of patients with lung cancer. High levels of POSTN correlated with immune cell infiltration in lung cancer, especially lung squamous cell carcinoma (LUSC), which was further confirmed based on the results from the TISIDB database. Moreover, the expression analysis, correlation analysis, and survival analysis revealed that POSTN-targeted miRNAs, downregulation of has-miR-144-3p and has-miR-30e-3p, were significantly linked to poor prognosis in patients with LUSC. Taken together, we identified that POSTN can act as a novel biomarker for determining the prognosis related to immune infiltration in patients with LUSC and deserves further research.

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“…Thus, this might indicate that this LLPS-related gene signature is still robust in different populations and suitable for different platforms. In some previous studies ( 30 , 31 ), univariate and multivariate Cox regression analyses were used but lack of LASSO analysis to create the prognostic gene signatures. However, these previous studies may encounter overfitting problems and not validated in independent data sets.…”

Section: Discussionmentioning

confidence: 99%

A Liquid-Liquid Phase Separation-Related Gene Signature as Prognostic Biomarker for Epithelial Ovarian Cancer

Qiu¹,

Pan²

2021

Front. Oncol.

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ObjectiveThe aim of the present study was to construct and test a liquid-liquid phase separation (LLPS)-related gene signature as a prognostic tool for epithelial ovarian cancer (EOC).Materials and MethodsThe data set GSE26712 was used to screen the differentially expressed LLPS-related genes. Functional enrichment analysis was performed to reveal the potential biological functions. GSE17260 and GSE32062 were combined as the discovery to construct an LLPS-related gene signature through a three-step analysis (univariate Cox, least absolute shrinkage and selection operator, and multivariate Cox analyses). The EOC data set from The Cancer Genome Atlas as the test set was used to test the LLPS-related gene signature.ResultsThe differentially expressed LLPS-related genes involved in several cancer-related pathways, such as MAPK signaling pathway, cell cycle, and DNA replication. Eleven genes were selected to construct the LLPS-related gene signature risk index as prognostic biomarker for EOC. The risk index could successfully divide patients with EOC into high- and low-risk groups. The patients in high-risk group had significantly shorter overall survival than those with in low-risk group. The LLPS-related gene signature was validated in the test set and may be an independent prognostic factor compared to routine clinical features.ConclusionWe constructed and validated an LLPS-related gene signature as a prognosis tool in EOC through integrated analysis of multiple data sets.

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<p>Construction and validation of a seven-microRNA signature as a prognostic tool for lung squamous cell carcinoma</p>

Cited by 11 publications

References 36 publications

REPS1 as a Potential Biomarker in Alzheimer’s Disease and Vascular Dementia

REPS1 as a Potential Biomarker in Alzheimer’s Disease and Vascular Dementia

miRNAs-mediated overexpression of Periostin is correlated with poor prognosis and immune infiltration in lung squamous cell carcinoma

A Liquid-Liquid Phase Separation-Related Gene Signature as Prognostic Biomarker for Epithelial Ovarian Cancer

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