&lt;p&gt;Correlation Between Serum Uric Acid Level and Central Body Fat Distribution in Patients with Type 2 Diabetes&lt;/p&gt;

Zong, Jing; Sun, Yi; Zhang, Yiqian; Wang, Xinlei; Zhang, Rongping; Zhao, Xiaoqin; Zhao, Xuying; Gu, Yunjuan

doi:10.2147/dmso.s260891

Cited by 22 publications

(15 citation statements)

References 45 publications

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“…For all participants, an increasing trend for mean levels of fat contents was found across the SUA levels. In line with previous studies ( 15 , 40 ), higher contents of percentage of total body fat, trunk fat mass, android fat mass, gynoid fat mass, VAT mass, and abdominal SAT mass showed a significantly positive association with the risk of hyperuricemia. However, after adjusting for all confounder factors, only VAT mass was significantly correlated with the high risk of hyperuricemia in PCOS patients.…”

Section: Discussionsupporting

confidence: 92%

“…To our knowledge, elevated SUA levels may have a variety of pro-inflammatory, pro-oxidative, vasoconstrictive actions and are commonly linked to the metabolic syndrome (8 ) , i n c l u d i n g h y p e r t e n s i o n , atherosclerosis, and adiposity (9). In some populations other than PCOS patients, such as healthy people, diabetic patients, and obese people, many scholars have conducted research on the relationship between uric acid or hyperuricemia and adiposity/ body fat distribution (10)(11)(12)(13)(14)(15)(16)(17). However, as far as we know, there are few epidemiological studies evaluating the relationship between uric acid or hyperuricemia and body fat distribution in patients with PCOS.…”

Section: Introductionmentioning

confidence: 99%

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Correlation Between Serum Uric Acid and Body Fat Distribution in Patients With Polycystic Ovary Syndrome

et al. 2022

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ObjectiveThis study aims to investigate the correlation between serum uric acid levels and body fat distribution in patients with polycystic ovary syndrome (PCOS).MethodsBetween May 2017 and March 2021, a total of 199 patients with PCOS were recruited from the Department of Endocrinology and Metabolism at the Shanghai Tenth People’s Hospital. Anthropometric characteristics, metabolic parameters, and reproductive hormones were measured. Hyperuricemia was defined as serum uric acid (SUA) greater than 420 μmol/l. Dual-energy X-ray absorptiometry (DEXA) was used to measure body fat distribution.ResultsThe prevalence of hyperuricemia in patients with PCOS was 28.64%. PCOS patients with hyperuricemia are more obese and have a higher waist-to-hip ratio (WHR) and worse lipid metabolism than those without hyperuricemia. According to SUA quartiles, patients in the highest quartile had higher total testosterone (TT), body fat accumulation, and lower sex hormone-binding globulin (SHBG) than patients in the lowest quartile. SUA was correlated with percentage of total body fat, arm fat mass, leg fat mass, trunk fat mass, android/gynoid (A/G) ratio, and visceral adipose tissue (VAT) mass. After controlling possible confounders, logistic regression analysis found that only excessive VAT mass could significantly increase the risk of hyperuricemia in patients with PCOS.ConclusionIn patients with PCOS, a high level of VAT mass, but not other fat compartments, will exacerbate the risk of hyperuricemia. Attention should be paid to the role of excessive VAT in the occurrence and development of PCOS with hyperuricemia.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Correlation Between Serum Uric Acid and Body Fat Distribution in Patients With Polycystic Ovary Syndrome

et al. 2022

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“…Epidemiological studies have established a significant association between IR and SUA ( 36 , 37 ), and compensatory hyperinsulinemia that occurs after IR can reduce uric acid excretion by renal tubular sodium reabsorption and cause HUA ( 38 ). Conversely, higher uric acid levels can reduce nitric oxide bioavailability and mitochondrial oxidative stress, leading to IR ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

Triglyceride Glucose Index Is More Closely Related to Hyperuricemia Than Obesity Indices in the Medical Checkup Population in Xinjiang, China

et al. 2022

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BackgroundHyperuricemia (HUA) is a metabolic anomaly with an increased incidence rate, causing a global medical burden. Several studies have confirmed that obesity and insulin resistance (IR) are the risk factors for HUA. Reports on the predictive power of different obesity indices for HUA are limited. This study aimed to compare the association between different general, abdominal, and visceral obesity indices and markers of the IR-triglyceride glucose (TyG) index with serum uric acid (SUA) and to assess the ability of these indices to predict HUA.MethodsA total of 2243 participants were recruited from Barkol County Hospital and surrounding township hospitals in Xinjiang. Obesity indices, including the atherogenic index of plasma, cardiometabolic index, visceral adiposity index, lipid accumulation product index, a body shape index, body roundness index, waist circumference, waist-to-height ratio, body mass index, and TyG index, were divided into four quartiles. Moreover, partial correlations and logistic regression were used to analyze the association between these indices and SUA. The area under the curve (AUC) and receiver operating characteristic curves were used to analyze the predictive value of these indices for HUA.ResultsAfter controlling for confounding variables, the association between the TyG index and HUA was stronger than that between the obesity indices in both males and females. The odds ratios (ORs) for HUA in the highest quartile of the TyG index were 2.098 (95% confidence interval, 1.555–2.831) in males and 7.788 (95% CI, 3.581–16.937) in females. For males, the AIP, CMI, VAI, LAP index, and TyG index were able to discriminate HUA, and the TyG index showed the highest AUC value of 0.586 (95% CI, 0.557–0.614; P < 0.001). For females, all indices, except BMI, can discriminate HUA. Moreover, the visceral obesity index CMI showed the highest AUC value of 0.737 (95% CI, 0.691–0.782; P < 0.001). Meanwhile, the TyG index had a relatively high AUC value of 0.728 (95% CI, 0.682–0.773; P < 0.001).ConclusionThe TyG index was significantly related to HUA and was superior to obesity indices in identifying HUA in the medical checkup population in Xinjiang, China.

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“…From a health check-up examination study, it was shown that visceral fat obesity (defined as visceral fat area, VFA >100 cm 2 ), measured using bioelectrical impedance analysis, was observed more frequently in patients with gout compared with healthy controls (15). A cross-sectional study of 867 patients with type 2 diabetes showed HU to be positively correlated with central body fat distribution, especially visceral adipose tissue (r = 0.328, p < 0.001) (16).…”

Section: Introductionmentioning

confidence: 99%

Decrease in Serum Urate Level Is Associated With Loss of Visceral Fat in Male Gout Patients

et al. 2021

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ObjectiveTo clarify the relationship between serum urate (SU) decrease and visceral fat area (VFA) reduction in patients with gout.MethodsWe retrospectively analyzed 237 male gout patients who had two sets of body composition and metabolic measurements within 6 months. Subjects included had all been treated with urate-lowering therapy (ULT) (febuxostat 20–80 mg/day or benzbromarone 25–50 mg/day, validated by the medical record). All patients were from the specialty gout clinic of The Affiliated Hospital of Qingdao University. The multiple linear regression model evaluated the relationship between change in SU [ΔSU, (baseline SU) – (final visit SU)] and change in VFA [ΔVFA, (baseline VFA) – (final visit VFA)].ResultsULT resulted in a mean (standard deviation) decrease in SU level (464.22 ± 110.21 μmol/L at baseline, 360.93 ± 91.66 μmol/L at the final visit, p <0.001) accompanied by a decrease in median (interquartile range) VFA [97.30 (81.15–118.55) at baseline, 90.90 (75.85–110.05) at the final visit, p < 0.001]. By multiple regression model, ΔSU was identified to be a significant determinant variable of decrease in VFA (beta, 0.302; p = 0.001).ConclusionsThe decrease in SU level is positively associated with reduced VFA. This finding provides a rationale for clinical trials to affirm whether ULT promotes loss of visceral fat in patients with gout.

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<p>Correlation Between Serum Uric Acid Level and Central Body Fat Distribution in Patients with Type 2 Diabetes</p>

Cited by 22 publications

References 45 publications

Correlation Between Serum Uric Acid and Body Fat Distribution in Patients With Polycystic Ovary Syndrome

Correlation Between Serum Uric Acid and Body Fat Distribution in Patients With Polycystic Ovary Syndrome

Triglyceride Glucose Index Is More Closely Related to Hyperuricemia Than Obesity Indices in the Medical Checkup Population in Xinjiang, China

Decrease in Serum Urate Level Is Associated With Loss of Visceral Fat in Male Gout Patients

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