&lt;p&gt;Determinants of Statin Initiation Among Adult Diabetic Patients in Bonga, Ethiopia&lt;/p&gt;

Kebede, Bezie; Feyisa, Desalegn

doi:10.2147/dmso.s283993

Cited by 5 publications

(6 citation statements)

References 21 publications

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“…Lastly, in comparison with Kebede Zelalem and Feyisa’s study where polypharmacy projected the initiation of statin therapy, this aforementioned variable had no impact on statin prescription in our study [ 26 ]. This sheds light on another potential concern, where patients on multiple medications are being equally treated as other patients.…”

Section: Discussioncontrasting

confidence: 68%

Statin Prescription Patterns Among Elderly Patients with Type 2 Diabetes: A Cross-Sectional Study in Lebanon

Souheil

Chahine

2022

Drugs - Real World Outcomes

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Background Even though statins have been proven to be effective in both primary and secondary prevention of cardiovascular disease among diabetic patients, a suboptimal use of the latter has been detected in real clinical practice, especially among older adults. Objective This study aimed to evaluate the patterns and predictors of statin use among elderly patients with type 2 diabetes mellitus (T2DM) in Lebanon. Methods This is a cross-sectional study that extended between April 2021 and February 2022. Our study involved elderly T2DM outpatients, aged 65–80 years, who presented to 40 community pharmacies for prescription filling. Diabetes status was ascertained via dispensed medication information, and patients were classified based on the American Diabetes Association preset risk scores for cardiovascular diseases in diabetics: low, moderate, or high risk. The questionnaire included patients' demographics, clinical information, and status of statin use. Results A total of 420 diabetic geriatric patients were observed in this study; their mean age was 70 years (± 7), and there was a predominance of males, 270 (64.3%). Almost all patients were classified as being at high risk, 396 (94.3%), while the rest were at moderate risk; thus, all were recommended to receive statins; however, statin prescription was only reported among 197 (46.9%), with atorvastatin and rosuvastatin being the most used: 102 (51.8%) and 62 (31.5%), respectively. Of patients prescribed statins, 60 (14.3%) were taking them for primary prevention and 137 (32.6%) for secondary prevention. Patients having a higher Charlson Comorbidity Index score had lesser odds of being prescribed statins (odds ratio [OR] 0.15, 95% confidence interval [CI] 0.02–0.8, p = 0.028); however, those presenting with a history of dyslipidemia and coronary artery disease had higher odds of statin prescription (OR 10.5, 95% CI 4.2–26.1, p < 0.001, and OR 5.0, 95% CI 2.4–10.5, p < 0.001, respectively). Conclusion Despite patients' eligibility to receive statins, statin undertreatment was evident among elderly outpatients with T2DM in Lebanon, which was modulated by several predictors. Supplementary Information The online version contains supplementary material available at 10.1007/s40801-022-00335-1.

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Section: Discussioncontrasting

confidence: 68%

Statin Prescription Patterns Among Elderly Patients with Type 2 Diabetes: A Cross-Sectional Study in Lebanon

Souheil

Chahine

2022

Drugs - Real World Outcomes

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“…Hence, the inappropriate indication of statins in T2DM populations drops a signi cant burden by adding unnecessary medication taken by the patients who tend to manifest unwanted side effects and have an impact on their nancial condition. This was supported in a study conducted in Bonga (19).…”

Section: Discussionsupporting

confidence: 54%

“…In addition to the above adopted tool, different literatures are reviewed to assess the factors that are associated with the use of ALTs (6, [19][20][21][22][23]. Then data was collected by using a semi-structured interviewer administered questionnaire and reviewing of patient medical records.…”

Section: Measurement Toolmentioning

confidence: 99%

Use of Antiplatelet and Lipid Lowering Agent Therapies as Primary Cardiovascular Disease Prevention Strategy and their Determinant Factors among Type 2 Diabetes Mellitus Patients in University of Gondar Comprehensive Specialized Hospital, Gondar: A Prospective Cross- sectional Study

Solomon

Tadesse

Tewabe

et al. 2023

Preprint

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Background: Patients with type 2 diabetes mellitus have two to four times increased risk of cardiovascular events compared with those without diabetes. Anti-platelet therapy and lipid lowering therapies have a significant contribution to prevent primary cardiovascular disease to achieve optimal patient outcomes. Objective: This study aimed to assess the use of antiplatelet and lipid lowering agent therapies as primary cardiovascular disease prevention strategies and their determinant factors among type 2 diabetes mellitus patients in University of Gondar Comprehensive Specialized Hospital, Gondar, Ethiopia. Methods: A prospective cross sectional study was conducted among 405 type 2 diabetes mellitus patients selected using a systematic random sampling method. Semi-structured questionnaire and data abstraction format were used for data collection. The data was collected from May 1 – July 30, 2022. The data was entered into Epidata version 3 and exported to SPSS version 25.0 statistical packages. Multivariable binary logistic regression analysis was done for identifying factors associated with use antiplatelet and lipid lowering agent. Statistical significance was declared at 95% confidence interval. Result:Out of 405 study participants, the majority of study participants 301 (74.3%) had low (<10%) 10-year cardiovascular disease risk and moderate risk was 75 (18.5%). Statin was used for 180 (44.4%) of the study participants. While 81mg aspirin was used for 38 participants. About 58.8% using statin appropriately while 89.9% of them using aspirin appropriately. Ages between 65 - 69 years old (AOR = 3.76, 95% CI: 1.33- 10.61), taking alcohol (AOR = 0.38, 95%: 0.23 - 0.64), being hypertensive (AOR = 2.30, 95%CI: 1.38-3.86) and using two or more glucose lowering agent (AOR = 4.60, 95%CI: 2.72- 7.78) were significantly associated with use of statin. On the other hand, use of more than one glucose lowering agent (AOR = 4.36, 95%CI: 1.64 - 11.61) and being hypertensive (AOR = 3.34, 95%CI: 1.24 - 8.96) were associated with the use of aspirin. Conclusion:The appropriate indication of lipid lowering agent was low. So, this population is at high potential risk for the development cardiovascular disease and predisposed to unwanted medication side effects. Also, aspirin was used for 10% of patients who were scored under high risk, which implicates these populations are at high risks for bleeding and Reye syndrome, despite the low benefit. These results emphasize the necessity of considering the cardiovascular disease risk of the patients and apply an appropriate measure for primary prevention.

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Section: Discussionmentioning

confidence: 99%

“…23 In an Indian study, only 55.2% of patients were on appropriate statin therapy, 24 and 42.5% of 120 patients in Bonga received statin. 25 On the other hand, only 16.8% of 1427 diabetic patients in Ghana took a statin. 26 Inappropriate statin treatment was found in 14.9% of participants, such as a moderate-or low-intensity statin instead of high-intensity statin, increasing the risk of ASCVD.…”

Section: Discussionmentioning

confidence: 99%

Adherence to Clinical Guidelines on STATIN Prescribing Among Diabetic Patients Aged 40–75 Years Old in a Primary Care Setting: A Cross-Sectional Study

Abukhalil¹,

Alyan²,

AbuAita³

et al. 2022

PPA

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Background Diabetes mellitus (D.M.) is a chronic metabolic disease caused by decreased insulin secretion, which increases the risk of cardiovascular diseases. Evidence has shown that statins reduce cardiovascular risk in patients with diabetes; moreover, most clinical guidelines recommend statins. Objective This study aimed to assess the level and status of adherence to guidelines on statin prescription in patients with diabetes mellitus in a primary care setting in Palestine. Methods A retrospective cross-sectional descriptive study was conducted at an ambulatory center in Palestine. Data were collected by auditing prescription records and reviewing medical charts of patients with diabetes who visited the clinic from February 15 to March 17, 2021. The collected data included patient characteristics, comorbidities, lipid profiles, and statin prescription. A chi-square test was used to evaluate the appropriateness of the prescribed statins with different demographic and clinical variables. Statistical significance was set at p < 0.05. Statistical Package for Social Sciences (SPSS) version 22 was used to analyze the data. Results Out Of 262 diabetic patients included in the analysis, 74% were prescribed appropriate statin therapy according to the American Diabetes Association (ADA) guidelines, and 24% of patients had inappropriate statin therapy or needed statins. Furthermore, 82.8% were on high-intensity statins, while 11% were not taking any statins. More than 60% of patients had uncontrolled diabetes and hypertension. Conclusion Most guidelines recommend statin therapy in diabetic patients owing to its benefits in preventing cardiovascular complications. In this study, most patients were on appropriate STATIN therapy; however, 50% of diabetic patients had LDL of more than 100 mg/dl, and 25% were not prescribed statins, increasing their risk of ASCVD. Therefore, we recommend strict adherence to the established guidelines on statins prescribed to patients with diabetes to prevent cardiovascular complications, save lives, and reduce healthcare costs.

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<p>Determinants of Statin Initiation Among Adult Diabetic Patients in Bonga, Ethiopia</p>

Cited by 5 publications

References 21 publications

Statin Prescription Patterns Among Elderly Patients with Type 2 Diabetes: A Cross-Sectional Study in Lebanon

Statin Prescription Patterns Among Elderly Patients with Type 2 Diabetes: A Cross-Sectional Study in Lebanon

Use of Antiplatelet and Lipid Lowering Agent Therapies as Primary Cardiovascular Disease Prevention Strategy and their Determinant Factors among Type 2 Diabetes Mellitus Patients in University of Gondar Comprehensive Specialized Hospital, Gondar: A Prospective Cross- sectional Study

Adherence to Clinical Guidelines on STATIN Prescribing Among Diabetic Patients Aged 40–75 Years Old in a Primary Care Setting: A Cross-Sectional Study

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