&lt;p&gt;Effect of Body Mass Index on Lung Function in Chinese Patients with Chronic Obstructive Pulmonary Disease: A Multicenter Cross-Sectional Study&lt;/p&gt;

Zhu, Jing; Zhao, Zhiling; Wu, Bin; Shi, Zhihong; Nie, Qingrong; Fu, Zhen; Zeng, Zhaofu; Hu, Weihua; Dong, Minglin; Xiong, Mengqing; Hu, Ke

doi:10.2147/copd.s265676

Cited by 9 publications

(5 citation statements)

References 35 publications

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“…For people with RLD, the FEV1/FVC and FEV1/FVC%predicted of overweight and obesity group were signi cantly higher than those of normal BMI group. Study by Jing Zhu also found that increased BMI had a protective effect on lung function in COPD GOLD 3-4 grade, which was consistent with our result [70]. Since nutritional status plays a signi cant role in the lung function in later stage COPD patients, the prognostic value of BMI was particularly convincing in patients with severe COPD [71].…”

Section: Discussionsupporting

confidence: 90%

Associations between different body mass index and risk of lung function impairment in Chinese people aged over 40 years: a multicenter cross-sectional study

Tang,

Zhang,

Zhu

et al. 2023

Preprint

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Objective The aim of this study was to explore the associations between different body mass index (BMI) levels and the risk of different lung function impairment (LFI) in Chinese people aged over 40 years. Methods We used a multi-stage stratified cluster random sampling method to investigate 3000 residents aged over 40 years from 5 areas in Hubei province of China in 2019-20. The data on questionnaire, physical measurements, and spirometry of the participants were collected. The associations of different BMI levels with the risk of different LFI were analyzed using multivariate logistic regressions after complex weighting. Results A total of 2860 subjects were included. The prevalence (95%CI) of obstructive lung disease (OLD), restrictive lung disease (RLD), mixed lung disease (MLD), chronic obstructive pulmonary disease (COPD), COPD mild, and COPD moderate/severe/very severe were 24.1% (95% CI: 22.2–26.2), 11.6% (95% CI: 10.3–12.9), 4.0% (95% CI: 3.3–4.8), 12.6% (95% CI: 11.0-14.1), 7.2% (95% CI: 6.0-8.4), and 5.3% (95% CI: 4.3–6.4) respectively. After multivariate adjustment, the risk of OLD, COPD, and COPD mild decreased with the increment of BMI levels (both P for trend < 0.05). When compared to the normal weight group, the overweight group and obese group were at lower risk of experiencing OLD than normal group, the ORs were 0.77 (95% CI: 0.59–0.99) and 0.59 (95% CI: 0.40–0.86) respectively. The obese group was at lower risk for people with COPD mild (OR: 0.42, 95%CI: 0.21–0.85). Participants in underweight group were more likely to experience COPD and COPD moderate/severe/very severe, the ORs were 2.82 (95% CI: 1.07–7.39) and 3.89 (95% CI: 1.28–11.87) respectively. Conclusion Higher BMI levels were associated with an decreased risk of OLD and COPD. Obesity had a protective effect on lung function in OLD patients and COPD patients. However, there was no significant difference in RLD and MLD prevalence between different BMI groups.

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Section: Discussionsupporting

confidence: 90%

Associations between different body mass index and risk of lung function impairment in Chinese people aged over 40 years: a multicenter cross-sectional study

Tang,

Zhang,

Zhu

et al. 2023

Preprint

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“… 41 Previous Chinese studies discovered that obesity only had a protective effect on lung function in COPD patients with Global Initiative for Chronic Obstructive Disease (GOLD) 3–4 grade rather than GOLD 1–2 grade. 38 , 42 Thus, the “obesity paradox” was found to exist among COPD patients, but how about people with PRISm and at risk of COPD? In this study, we conducted further analysis in these two population groups and found obesity to be a protective factor for lung function.…”

Section: Discussionmentioning

confidence: 99%

“…An accumulating body of evidence paradoxically links increasing body mass index with a better prognosis, and this phenomenon is termed the "obesity paradox". 32 The "obesity paradox" has been found in many diseases, including cardiovascular disease, [33][34][35] kidney disease, 36 diabetes, 37 chronic respiratory disease, 32,38,39 osteoporosis, 40 and cancer. 41 Previous Chinese studies discovered that obesity only had a protective effect on lung function in COPD patients with Global Initiative for Chronic Obstructive Disease (GOLD) 3-4 grade rather than GOLD 1-2 grade.…”

Section: Comparison With Other Studiesmentioning

confidence: 99%

The Relationship Between BMI and Lung Function in Populations with Different Characteristics: A Cross-Sectional Study Based on the Enjoying Breathing Program in China

Tang¹,

Lei²,

Li³

et al. 2022

COPD

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Purpose To analyze the relationship between body mass index (BMI) and lung function, which may help optimize the screening and management process for chronic obstructive pulmonary disease (COPD) in the early stages. Patients and Methods In this cross-sectional study using data from the Enjoying Breathing Program in China, participants were divided into two groups according to COPD Screening Questionnaire (COPD-SQ) scores (at risk and not at risk of COPD) and three groups based on lung function (normal lung function, preserved ratio impaired spirometry [PRISm], and obstructive lung function). Results A total of 32,033 subjects were enrolled in the current analysis. First, in people at risk of COPD, overweight and obese participants had better forced expiratory volume in one second (FEV1; overweight: 0.33 liters (l), 95% confidence interval [CI]: 0.27 to 0.38; obesity: 0.31 L, 95% CI: 0.22 to 0.39) values than the normal BMI group. Second, among people with PRISm, underweight participants had a lower FEV1 (−0.56 L, 95% CI: −0.86 to −0.26) and forced vital capacity (FVC; −0.33 L, 95% CI: −0.55 to −0.11) than participants with a normal weight, and obese participants had a higher FEV1 (0.22 L, 95% CI: 0.02 to 0.42) and FVC (0.16 L, 95% CI: 0.02 to 0.30) than participants with a normal weight. Taking normal BMI as the reference group, lower FEV1 (−0.80 L, 95% CI: −0.97 to −0.63) and FVC (−0.53 L, 95% CI: −0.64 to −0.42) were found in underweight participants with obstructive spirometry, and better FEV1 (obesity: 0.26 L, 95% CI: 0.12 to 0.40) was found in obese participants with obstructive spirometry. Conclusion Being underweight and severely obese are associated with reduced lung function. Slight obesity was shown to be a protective factor for lung function in people at risk of COPD and those with PRISm.

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“…In recent years, the associations of obesity with reduced pulmonary function and chronic airway disease have received considerable attention [ 51 – 53 ]. In particular, a close relationship between obesity and VCI has been suggested [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

The associations between body composition and vital capacity index of medical students in Shenyang of China: a cross-sectional survey

Zhang

Sun

et al. 2022

BMC Pulm Med

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Objectives This study aimed to examine the associations between body composition and vital capacity index (VCI) among medical students of Shenyang, China. Study design The design of this study is a cross-sectional study. Methods Participants were 2063 individuals (17–25 years) from a medical college in Shenyang, who participated in this survey from April to May 2017. Height, weight, fat mass (FM), fat free mass (FFM), protein mass (PM), total body water (TBW), mineral mass (MM), vital capacity were measured, then BMI and VCI were calculated. Stepwise multiple linear regression analysis was used to evaluate the effect of body composition on VCI of participants in different genders. In addition, subgroup analysis was carried out according to BMI levels. Results Male students showed significantly higher height, weight, BMI, FFM, PM, TBW, MM, VC, and VCI, but lower FM in comparison with female students. Stepwise multiple linear regression analysis showed that in both sexes FM was negatively correlated with VCI which represents pulmonary function (r < 0; P < 0.001). After dividing the whole participants by BMI, further correlation analysis showed FM was positively correlated with VCI only for male subgroups with BMI < 18.5 (r > 0; P = 0.050). Conclusion Overall, FM is highly negatively correlated with the VCI of Chinese medical students of both genders. However, there was a positive correlation between FM and VCI among low-weight male students.

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<p>Effect of Body Mass Index on Lung Function in Chinese Patients with Chronic Obstructive Pulmonary Disease: A Multicenter Cross-Sectional Study</p>

Cited by 9 publications

References 35 publications

Associations between different body mass index and risk of lung function impairment in Chinese people aged over 40 years: a multicenter cross-sectional study

Associations between different body mass index and risk of lung function impairment in Chinese people aged over 40 years: a multicenter cross-sectional study

The Relationship Between BMI and Lung Function in Populations with Different Characteristics: A Cross-Sectional Study Based on the Enjoying Breathing Program in China

The associations between body composition and vital capacity index of medical students in Shenyang of China: a cross-sectional survey

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