<p>Effect of Clinical and Treatment Factors on Survival Outcomes of Triple Negative Breast Cancer Patients</p>

Abstract

Purpose: Triple negative breast cancer (TNBC) accounts for approximately 15% of breast cancer cases and is associated with a poor prognosis. In this retrospective study of patients undergoing radiation therapy as part of their treatment, disease-free survival (DFS) and overall survival (OS) of TNBC patients were examined in relation to clinical and treatmentrelated factors. Patients and Methods: The electronic records of 214 consecutive TNBC patients treated with surgery followed by radiotherapy at the Mid North Coast Cancer Institute between 2006 and 2016 were reviewed. Overall survival and DFS times were analyzed using the Kaplan-Meier method; multivariate Cox proportional hazard regression modelling was used to assess the significance of prognostic factors. Results: The majority of tumors were T1 (51.9%), followed by T2 (39.2%) and T3 (6.1%). For the whole group, mean DFS was 106.4 (SD 48.7) months; OS 109.4 (SD 52.1) months. Radiotherapy technique, fractionation protocol and laterality were not significant factors for DFS or OS (p>0.05). However, compared to breast conservation, mastectomy was associated with poorer DFS (mean 114.2 vs 65.2 months; p<0.0001) and poorer OS (mean 115.5 vs 80.5 months; p=0.0015). The mastectomy group had fewer patients with tumor size T1 (p=0.001) and higher proportions of T3 (p=0.001) and T4 (p=0.02). On multivariate analysis, tumor size T3/T4 and nodal status N2/N3 were significant factors for reduced DFS (p=0.023 and p=0.0003 respectively). Tumor size T3/T4 was the only significant prognostic factor for reduced OS (p=0.019). Conclusion: Advanced disease exhibited by tumor size > 5cm and positive nodal status is associated with poorer DFS in TNBC patients. Radiotherapy technique or fractionation protocol were not associated with differences in DFS or OS in our patient cohort.

The Functional Impact of Alternative Splicing on the Survival Prognosis of Triple-Negative Breast Cancer

“…The survival analysis of TNBC has gotten enough attention from researchers around the world due to its severity and poor survival outcome. There are several studies focusing on the roles of clinical and treatment factors ( Xiao, 2016 ; Kim et al, 2019 ; Wen et al, 2020 ), radiomics features ( Kim S. et al, 2020 ; Koh et al, 2020 ), circulating tumor cells ( Karhade, 2012 ), and gene expressions ( Kim et al, 2016 ; Purrington et al, 2020 ; Wu et al, 2020 ) in the survival prognosis of TNBC. The research groups of these studies tried to find the significant risk factors for TNBC survival and further contributed to the treatment of TNBC.…”

Survival outcomes for breast cancer patients who decline recommended treatment: a propensity score‐matched analysis

“…There is a need for multi-centre research exploring the potential factors which influence the decision to accept, decline or delay cancer treatments in the Australian metropolitan and non-metropolitan context, even when ease of access to high-quality treatment 24 with excellent tumour control outcomes exists. 25…”

Metaplastic carcinoma of the breast: Clinicopathological features and treatment outcomes with long‑term follow up

“…We also reviewed the radiation therapy fractionation and radiation field, extent of surgery, and details of systemic therapy. We have previously published our treatment techniques and outcomes for patients with breast cancer (14)(15)(16)(17). Tumour and nodal staging was based on findings at wide local excision or mastectomy, or in the case of neoadjuvant systemic therapy, based on radiological findings in addition to the pathological specimen.…”