&lt;p&gt;Effectiveness of Action Observation Training on Upper Limb Motor Function in Children with Hemiplegic Cerebral Palsy: A Systematic Review of Randomized Controlled Trials&lt;/p&gt;

Alamer, Abayneh; Melese, Haimanot; Adugna, Belaynew

doi:10.2147/phmt.s266720

Cited by 23 publications

(18 citation statements)

References 45 publications

(117 reference statements)

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“…Rehabilitation may be further optimized by implementing strategies that target visuomotor processes, and sensorimotor integration in particular, as both initial (mal) adaptation and recovery occur in visuomotor brain areas involved in forming sensorimotor representations. Visuomotor strategies that have been successfully applied in other neurological disorders include mirror visual feedback, 48 action observation, 49 and graded motor imagery. 50 Future research could focus on identifying rehabilitation strategies to effectively target cerebral mechanisms in NA and other peripheral nerve disorders.…”

Section: Conclusion and Clinical Implicationsmentioning

confidence: 99%

Cerebral Adaptation Associated with Peripheral Nerve Recovery in Neuralgic Amyotrophy: A Randomized Controlled Trial

Lustenhouwer

Cameron

Alfen

et al. 2022

Neurorehabil Neural Repair

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Background: Neuralgic amyotrophy (NA) is a common peripheral nerve disorder caused by auto-immune inflammation of nerves in the brachial plexus territory, characterized by acute pain and weakness of the shoulder muscles, followed by motor impairment. Recent work has confirmed that NA patients with residual motor dysfunction have abnormal cerebral sensorimotor representations of their affected upper extremity. Objective: To determine whether abnormal cerebral sensorimotor representations associated with NA can be altered by specialized, multidisciplinary outpatient rehabilitation focused on relearning motor control. Methods: 27 NA patients with residual lateralized symptoms in the right upper extremity participated in a randomized controlled trial, comparing 17 weeks of multidisciplinary rehabilitation ( n = 16) to usual care ( n = 11). We used task-based functional MRI and a hand laterality judgment task, which involves motor imagery and is sensitive to altered cerebral sensorimotor representations of the upper extremity. Results: Change in task performance and related brain activity did not differ significantly between the multidisciplinary rehabilitation and usual care groups, whereas the multidisciplinary rehabilitation group showed significantly greater clinical improvement on the Shoulder Rating Questionnaire. Both groups, however, showed a significant improvement in task performance from baseline to follow-up, and significantly increased activity in visuomotor occipito-parietal brain areas, both specific to their affected upper extremity. Conclusions: Abnormal cerebral sensorimotor representations of the upper extremity after peripheral nerve damage in NA can recover toward normality. As adaptations occurred in visuomotor brain areas, multidisciplinary rehabilitation after peripheral nerve damage may be further optimized by applying visuomotor strategies. This study is registered at ClinicalTrials.gov (NCT03441347).

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Section: Conclusion and Clinical Implicationsmentioning

confidence: 99%

Cerebral Adaptation Associated with Peripheral Nerve Recovery in Neuralgic Amyotrophy: A Randomized Controlled Trial

Lustenhouwer

Cameron

Alfen

et al. 2022

Neurorehabil Neural Repair

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“…HABIT-ILE is a 90-hour training intervention offered in a day camp model. Action-observation training shows promise for augmenting upper limb function training effects by having the infant or child mimic demonstrations of successful actions on an object via activation of the mirror neuron system [33]. However, insufficient evidence is available to support using action-observations in isolation or above other task-specific interventions [34].…”

Section: Motor Interventions To Improve Functionmentioning

confidence: 99%

Commentary and Clinical Implications of “State of the Evidence Traffic Lights 2019: Systematic Review of Interventions for Preventing and Treating Children with Cerebral Palsy”

2021

Journal of Experimental Neurology

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“…24 Recently, two systematic reviews regarding the effectiveness of AOT in the UL rehabilitation of children with cerebral palsy were published: the first emphasises that the variability between studies does not lead to any clear conclusion regarding the effectiveness of this approach, 25 while the second suggests that AOT is a promising intervention for UL rehabilitation in children with UCP. 26 Standard AOT consists in the observation of a typically developed model (TDM); however, an important assumption of AOT is that the MNS activates when the visual description of the observed action is matched with its corresponding motor representation in the observer's brain (direct matching hypothesis). 27 In fact, it has been shown that while observed actions belonging to the behavioural repertoire of the observer are mapped on his/her motor system, 28 those that belong only to her/ his visual experience are only categorised based on visual characteristics, without inducing any motor resonance phenomenon in the observer's brain.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Can a pathological model improve the abilities of the paretic hand in hemiplegic children? The PAM-AOT study protocol of a randomised controlled trial

et al. 2021

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IntroductionAction Observation Treatment (AOT) is an innovative therapeutic approach consisting in the observation of actions followed by subsequent repetition. In children with unilateral cerebral palsy (UCP), it improves upper limb function in daily activities. The standard paradigm of AOT requires the observation of healthy models; however, it has been demonstrated that the mirror neuron system of children with UCP is more activated by observation of pathological models, showing a similar motor repertoire, than by the healthy model, suggesting that AOT based on pathological models is superior to the standard paradigm of AOT in the functional rehabilitation of the affected upper limb of children with UCP.Methods and analysisThis protocol describes an active two-arm randomised controlled evaluator-blinded trial. Twenty-six children with UCP will participate in 3 weeks of intensive AOT: the experimental group will observe a pathological model, while the control group will observe a typically developed model. The primary outcome is the spontaneous use of the paretic hand, measured with the Assisting Hand Assessment. Secondary outcome measures are the Melbourne Assessment of Unilateral Upper Limb Function, the ABILHAND-Kids and the Activities Scale for Kids-performance. Assessments will be performed at baseline (T0), at the end of intensive AOT (T1), at 8–12 weeks (T2) and at 24–28 weeks (T3) after the end of intensive AOT.Ethics and disseminationThe trial was approved by the Area Vasta Emilia Nord Ethics Committee (AVEN prot. n. 133117, 29 November 2018), and it was prospectively registered on ClinicalTrials.gov. The results will be submitted for publication to a peer-reviewed journal, discussed with parents of children participating in the trial and disseminated at suitable conferences.Trial registration numberNCT04088994; Pre-results.

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<p>Effectiveness of Action Observation Training on Upper Limb Motor Function in Children with Hemiplegic Cerebral Palsy: A Systematic Review of Randomized Controlled Trials</p>

Cited by 23 publications

References 45 publications

Cerebral Adaptation Associated with Peripheral Nerve Recovery in Neuralgic Amyotrophy: A Randomized Controlled Trial

Cerebral Adaptation Associated with Peripheral Nerve Recovery in Neuralgic Amyotrophy: A Randomized Controlled Trial

Commentary and Clinical Implications of “State of the Evidence Traffic Lights 2019: Systematic Review of Interventions for Preventing and Treating Children with Cerebral Palsy”

Can a pathological model improve the abilities of the paretic hand in hemiplegic children? The PAM-AOT study protocol of a randomised controlled trial

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