&lt;p&gt;Effects of melatonin in children with attention-deficit/hyperactivity disorder with sleep disorders after methylphenidate treatment&lt;/p&gt;

Masi, Gabriele; Fantozzi, Pamela; Villafranca, Arianna; Tacchi, Annalisa; Ricci, Federica; Ruglioni, Laura; Inguaggiato, Emanuela; Pfanner, Chiara; Cortese, Samuele

doi:10.2147/ndt.s193891

Cited by 20 publications

(12 citation statements)

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“…The effects of MLT supplementation after the first weeks were comparable with those observed after 3 months [114]. Masi et al and Weiss et al found that combination therapy of MPH and MLT was effective and safe [82,113].…”

Section: Safety Of Exogenous Melatonin In Pediatric Patientsmentioning

confidence: 60%

“…The effects of melatonin supplementation in ASD patients are shown in [59] did not confirm the influence of exogenous melatonin on the change of awakening frequency. Moreover, in the literature, the researchers also indicate a mild hypnotic [82,91,106], chronobiotic effect and improved daily behavior [59,107].…”

Section: Melatonin In the Treatment Of Sleep Disorders In Childrenmentioning

confidence: 91%

“…Drugs can be divided into two major groups, i.e., psychostimulants such as methylphenidate (MPH), which is the first-line drug, and non-psychostimulants (e.g., atomoxetine, which is a centrally acting sympathomimetic) [82]. According to some researchers, sleep disorders can be an adverse effect of stimulant drugs [24,82,83] as they can disturb the sleep pattern [84]. Schachter et al observed that patients on MPH were affected by insomnia more frequently compared to the placebo group [85].…”

Section: Adhdmentioning

confidence: 99%

“…TjonPian Gi et al reported that the time of falling asleep after MLT administration varied between 15-64 min [114] in ADHD subjects on MPH and MLT at a dose of 3 mg. In turn, Masi et al reported improved sleep in 60.8% of ADHD patients treated with MPH after MLT therapy (mean dosage 1.85 ± 0.84 mg/d) [82]. Schemes of conducted research and effects of melatonin therapy in the group of patients with ADHD are summarized in Tables 5 and 6.…”

Section: Adhdmentioning

confidence: 99%

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Efficacy and Safety of Melatonin Treatment in Children with Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder—A Review of the Literature

Rzepka-Migut¹,

Paprocka

2020

Brain Sciences

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Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are neurodevelopmental disorders with disturbed melatonin secretion profile and sleep problems. The growing incidence of ASD and ADHD inspires scientists to research the underlying causes of these conditions. The authors focused on two fundamental aspects, the first one being the presentation of the role of melatonin in ASD and ADHD and the second of the influence of melatonin treatment on sleep disorders. The authors present the use of melatonin both in the context of causal and symptomatic treatment and discuss melatonin supplementation: Dosage patterns, effectiveness, and safety. Sleep disorders may have a different clinical picture, so the assessment of exogenous melatonin efficacy should also refer to a specific group of symptoms. The review draws attention to the wide range of doses of melatonin used in supplementation and the need to introduce unified standards especially in the group of pediatric patients.Brain Sci. 2020, 10, 219 2 of 21 requiring flexibility and behavioral problems [9]. In the presented disorders, the clinical picture is heterogeneous [10] and the etiology is still unclear [11].Autism spectrum disorder (ASD) can be defined based on the diagnostic criteria which include communication and social interaction disorders and limited repetitive patterns of behavior and interests. In addition to the fundamental symptoms, many patients also present with anxiety attacks, (self)-aggression, mood disorders, and sleep difficulties [12,13]. The first symptoms of autism are observed already in early childhood and usually persist throughout life. An increase in the incidence of ASD has been reported over recent years. According to the CDC's Autism and Developmental Disabilities Monitoring (ADDM) report in 2000 the incidence of ASD was estimated at 1 in 150 children, in 2014 this incidence was 1 diagnosis in 59 children at the age of 8 [14]. The causes of this tendency may be different, e.g., a higher standard of medical and diagnostic care [15], higher social awareness, and the older age of parents at childbearing [16,17]. The etiology of ASD is most likely multifactorial [11], being the result of genetic and environmental factors [6]. Hallmayer et al. indicated the predominance of environmental factors, estimating the shared environmental component to be 58% and heritability to 38%. This distribution was similar among women and men [18]. So far multiple potential risk factors for ASD have been reported in the literature, including the use of illicit drugs during pregnancy, medications, organophosphate pesticides [19], fatty acid deficiency [20], gestational diabetes, and low birth weight [11]. Despite numerous scientific studies, no genetic abnormality that would account for more than 1% of ASD has been identified yet [11]. One of the hypothesis defines ASD as a collection of many forms of a rare monogenic disorder with a different etiology [21]. Ten percent of ASD can be explained as a component of a specific genetic sy...

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Section: Safety Of Exogenous Melatonin In Pediatric Patientsmentioning

confidence: 60%

Section: Melatonin In the Treatment Of Sleep Disorders In Childrenmentioning

confidence: 91%

Section: Adhdmentioning

confidence: 99%

Section: Adhdmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy and Safety of Melatonin Treatment in Children with Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder—A Review of the Literature

Rzepka-Migut¹,

Paprocka

2020

Brain Sciences

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“…56 At the same time, there have been observed benefits of NVNM dietary supplements in conjunction with medications, such as melatonin for insomnia treatment among children with attention deficit hyperactivity disorder using stimulant types of prescription medications. 57…”

Section: Discussionmentioning

confidence: 99%

Trends in Nutrient- and Non-Nutrient–Containing Dietary Supplement Use among US Children from 1999 to 2016

Panjwani

Cowan

Jun

et al. 2021

The Journal of Pediatrics

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Objectives To characterize dietary supplement use among US children, including product type, motivations, user characteristics, and trends over time with a primary focus on non-vitamin/non-mineral dietary supplements (NVNM). Study designOverall, NVNM, and vitamin and/or mineral dietary supplement only (VM-only) use; motivations for use; and trends in use over time were examined in children (£19 years of age) using the National Health and Nutrition Examination Survey 1999-2016 data (n = 42 510).Results Between 1999 and 2016, overall dietary supplement and VM-only dietary supplement use among all children remained relatively stable at 30%; yet, NVNM dietary supplement use increased from 2.9% to 6.4%, mainly due to increased use of omega-3 polyunsaturated fatty acids. NVNM use was greater in boys than in girls (3.9% vs 3.3%), and greater in older children than in younger children (P trend < .0001), the opposite of what was observed with VM-only dietary supplement use. Although both user groups shared 2 primary motivations, both motivations were reported by a significantly greater percent of vitamin and/or mineral dietary supplement users vs NVNM users: to maintain health (38.7% vs 23.1%) and to improve health (33.1% vs 22.6%). NVNM users were much more likely to use dietary supplement for relaxation, stress, and sleep; for mental health; and for colon and bowel health.Conclusions Although the prevalence of any dietary supplement and VM-only dietary supplement use among US children has both remained stable, the prevalence of NVNM use has increased substantially over time. Yet, NVNM use remains relatively low overall. NVNM use exhibited different patterns by sex, age, and motivations when compared with vitamin and/or mineral dietary supplement use. Despite increasing NVNM use, high-quality evidence supporting their use is lacking, especially in children.

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The Role of the Circadian System in Attention Deficit Hyperactivity Disorder

Bondopadhyay

Díaz-Orueta

Coogan

2021

Advances in Experimental Medicine and Biology

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part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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<p>Effects of melatonin in children with attention-deficit/hyperactivity disorder with sleep disorders after methylphenidate treatment</p>

Cited by 20 publications

References 20 publications

Efficacy and Safety of Melatonin Treatment in Children with Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder—A Review of the Literature

Efficacy and Safety of Melatonin Treatment in Children with Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder—A Review of the Literature

Trends in Nutrient- and Non-Nutrient–Containing Dietary Supplement Use among US Children from 1999 to 2016

The Role of the Circadian System in Attention Deficit Hyperactivity Disorder

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