&lt;p&gt;Effects of short-term oral vitamin A supplementation on the ocular tear film in patients with dry eye&lt;/p&gt;

Alanazi, Saud A.; El‐Hiti, Gamal A.; Al-Baloud, Abdulaziz A; Alfarhan, Mohamed I; Al-Shahrani, Ammar; Albakri, Abdulkareem A; Al-Qahtani, Saad; Masmali, Ali M.

doi:10.2147/opth.s198349

Cited by 40 publications

(31 citation statements)

References 48 publications

(51 reference statements)

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“…103 Other vitamins involved in ocular surface health are vitamins A and D used as oral supplements and vitamin A as a topical application, which have demonstrated an improvement in DED signs and symptoms. [104][105][106][107] Amino acid-enriched tear substitutes have been proven to be effective in improving corneal nerve structure in patients with DED. 108 Possible future developments will consider the use of biological drugs in the treatment of DED and associated conditions such as psoriasis.…”

Section: Nerve Treatmentmentioning

confidence: 99%

Modern approach to the treatment of dry eye, a complex multifactorial disease: a P.I.C.A.S.S.O. board review

Aragona

Giannaccare

Mencucci³

et al. 2020

Br J Ophthalmol

107

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Dry eye disease (DED) is a growing public health concern affecting quality of life and visual function, with a significant socio-economic impact. It is characterised by the loss of homoeostasis, resulting in tear film instability, hyperosmolarity and inflammation of the ocular surface. If the innate immune response is unable to cope with internal bodily or environmental adverse conditions, the persistent, self-maintaining vicious circle of inflammation leads to the chronic form of the disease. Treatment of DED should be aimed at the restoration of the homoeostasis of the ocular surface system. A proper diagnostic approach is fundamental to define the relevance and importance of each of the DED main pathogenic factors, namely tear film instability, epithelial damage and inflammation. Consideration also needs to be given concerning two other pathogenic elements: lid margin changes and nerve damage. All the factors that maintain the vicious circle of DED in the patient’s clinical presentation have to be considered and possibly treated simultaneously. The treatment should be long-lasting and personalised since it has to be adapted to the different clinical conditions observed along the course of the disease. Since DED treatment is frequently unable to provide fast and complete relief from symptoms, empathy with patients and willingness to explain to them the natural history of the disease are mandatory to improve patients’ compliance. Furthermore, patients should be instructed about the possible need to increase the frequency and/or change the type of treatment according to the fluctuation of symptoms, following a preplanned rescue regimen.

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Section: Nerve Treatmentmentioning

confidence: 99%

Modern approach to the treatment of dry eye, a complex multifactorial disease: a P.I.C.A.S.S.O. board review

Aragona

Giannaccare

Mencucci³

et al. 2020

Br J Ophthalmol

107

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“…This is associated with a reversal of the process of squamous metaplasia, as documented by conjunctival impression cytology [75]. Furthermore, a recent clinical study has shown that short-term vitamin A supplementation in patients with DED improves the quality of tears [78].…”

Section: Vitamin Amentioning

confidence: 99%

The Role of Nutrition and Nutritional Supplements in Ocular Surface Diseases

et al. 2020

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Dry eye disease (DED) is a multifactorial disease of the ocular surface system whose chore mechanisms are tear film instability, inflammation, tear hyperosmolarity and epithelial damage. In recent years, novel therapies specifically targeting inflammation and oxidative stress are being investigated and used in this field. Therefore, an increasing body of evidence supporting the possible role of different micronutrients and nutraceutical products for the treatment of ocular surface diseases is now available. In the present review, we analyzed in detail the effects on ocular surface of omega-3 fatty acids, vitamins A, B12, C, D, selenium, curcumin and flavonoids. Among these, the efficacy of omega-3 fatty acid supplementation in ameliorating DED signs and symptoms is supported by robust scientific evidence. Further long-term clinical trials are warranted to confirm the safety and efficacy of the supplementation of the other micronutrients and nutraceuticals.

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“…the ocular surface disease index, OSDI) [17]. Several diagnostic tests have been used to the assess eye dryness in terms of the quality and quantity of tears [18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Tear Evaporation Rate in Chronic Smokers Using Delfin VapoMeter

Alanazi¹

2019

IJOVS

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Background: Smoking cigarettes is associated with many chronic illnesses such as cancer, heart diseases, and cataract. In addition, smokers are more likely to develop dry eye symptoms compared with nonsmokers. Purpose: To assess the tear evaporation rate in chronic smokers using a VapoMeter. Materials and Method: This observational, case-control and nonrandomized study included one hundred and twenty male smokers that ranged in age from 18 to 43 years (mean ± SD = 25.4±5.8 years). An age (18-43 years) matching control group (120 male subjects), with a mean age of 26.1±5.2 years participated in the study. Each participant completed the ocular surface disease index dry eye questionnaire, then a VapoMeter was used to determine the tear evaporation rate. Result: Significant (Kolmogorov-Smirnov test; p<0.05) differences were found between the average scores collected from the ocular surface disease index and the tear evaporation rate measurements within the smokers and nonsmokers groups. The average tear evaporation rate was significantly (p<0.05) higher in the study group [median (interquartile range; IQR) = 37.7 (59.3) g/m 2 h] compared with that obtained in control group [15.4 (13.1) g/m 2 h]. Moreover, the average score from the ocular surface disease index in smokers was significantly (p<0.05) higher [15.4 (13.1)] compared with that obtained in the control group [5.4 (5.5)]. Conclusion: Smokers have significant higher tear evaporation rates compared with nonsmokers and normal eye subjects. Clearly, VapoMeter can be used as a reliable tool to assess the eye dryness due to excessive evaporation of tears. Smoking is a risk factor for cancer, heart diseases, and cataract. In addition, smoking is a risk factor for eye dryness and contributes to evaporative dry eye disease, more likely due to the disturbance in the non-polar lipid layer within the tear film. Lipid-rich eye drops could be used to manage dry eye symptoms in smoker subjects. Moreover, smoking cessation remains the single most effective prophylactic measure to avoid dry eye symptoms.

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<p>Effects of short-term oral vitamin A supplementation on the ocular tear film in patients with dry eye</p>

Cited by 40 publications

References 48 publications

Modern approach to the treatment of dry eye, a complex multifactorial disease: a P.I.C.A.S.S.O. board review

Modern approach to the treatment of dry eye, a complex multifactorial disease: a P.I.C.A.S.S.O. board review

The Role of Nutrition and Nutritional Supplements in Ocular Surface Diseases

Assessment of the Tear Evaporation Rate in Chronic Smokers Using Delfin VapoMeter

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