&lt;p&gt;Expression and significance of LncRNA MNX1-AS1 in non-small cell lung cancer&lt;/p&gt;

Liu, Gaofeng; Guo, Xiaofeng; Zhang, Yong; Liu, Yan; Li, Dandan; Tang, Guangyao; Cui, Sujuan

doi:10.2147/ott.s198014

Cited by 16 publications

(16 citation statements)

References 20 publications

(17 reference statements)

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“…Long non-coding RNAs (lncRNAs), a heterogeneous class of transcripts with a minimum length of 200 bases and limited protein-coding potential, was recently presented as a potential target for numerous cancers by interacting with RNAs and proteins (3). LncRNA MNX-AS1, known as Motor neuron and pancreas homeobox 1-antisense RNA1, was reported overexpressing in several tumor types such as gastric cancer, non-small cell lung cancer (NSCLC) and breast cancer and others (4)(5)(6). However, how MNX-AS1 leads to the progression and poor survival outcome of breast cancer, especially of TNBC needed to be explored.…”

Section: Introductionmentioning

confidence: 99%

Long Non-Coding RNA MNX1-AS1 Promotes Progression of Triple Negative Breast Cancer by Enhancing Phosphorylation of Stat3

et al. 2020

Front. Oncol.

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Triple negative breast cancer (TNBC) accounts for less than a quarter of breast cancer but has the poorest survival outcome and is prone to relapse as well as metastasis due to its aggressiveness and lack of therapeutic target. Herein, we analyzed the TCGA datasets of lncRNA expressional profiles of breast cancer vs. normal tissue and TNBC vs. Non-TNBC subtypes and screened a long non-coding RNA (lncRNA) MNX1-AS1 overexpressing in TNBC. We found that MNX1-AS1 were upregulated in TNBC tumor tissues and correlated with poor survival outcome in TNBC patients. Silencing MNX1-AS1 reduced the aggressiveness of TNBC in vitro and in vivo. By using RNA pulldown assay followed by western blotting and RNA immunoprecipitation (RIP), we identified Stat3 was the MNX1-AS1 binding protein and MNX1-AS1 upregulated the phosphorylation of Stat3 by enhancing the interaction between p-JAK and Stat3. The present study suggested that targeting MNX1-AS1 may represent a promising therapeutic strategy to TNBC.

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Section: Introductionmentioning

confidence: 99%

Long Non-Coding RNA MNX1-AS1 Promotes Progression of Triple Negative Breast Cancer by Enhancing Phosphorylation of Stat3

et al. 2020

Front. Oncol.

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“…A total of 882 patients from the all eligible articles were included to evaluate prognostic value of MNX1-AS1 (presented in Table 1). All articles covered gastric cancer(GC) (n = 3) [8][9][10], lung cancer (LC) (n = 3) [6,20,21], other cancer(n = 3) including: esophageal squamous cell carcinoma (ESCC), cervical cancer (CC), epithelial ovarian cancer (EOC) [14,18,22].…”

Section: Search Results Of Eligible Studiesmentioning

confidence: 99%

“…Discussion MNX1-AS1, also known as MAYA and CCAT5, is located at chromosome 7q36.3 [6]. Upregulation of MNX1-AS1 expression has been found in a variety of cancers, including gastric cancer [8][9][10], lung cancer [6,20,21], esophageal squamous cell carcinoma [14,15], and estrogen-dependent cancer [7,18,22], etc. MNX1-AS1 play a role of functional oncogene in addition to activating AKT/mTOR pathway and its natural sense transcript MNX1 in breast cancer cells, it also promotes the process of EMT [7].…”

Section: Involvement Of Mnx1-as1 In Carcinogenesismentioning

confidence: 99%

The prognostic utility and clinical outcomes of MNX1-AS1 expression in cancers: a systematic review and meta-analysis

Li¹,

Wen²,

Zhang³

et al. 2020

Preprint

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Background: Recently, emerging studies have identified that MNX1-AS1 highly expressed among variety of cancers and related with worse prognosis of cancer patients. The purpose of this study was to evaluate the relationship between MNX1-AS1 expression with clinical features and prognosis in different cancers. Methods: In this study, we searched the Web of Science, PubMed, CNKI, and Wanfang databases to find relevant studies of MNX1-AS1. Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were applied to explore the prognostic and clinical significance of MNX1-AS1. Results: A total of 9 literatures were included in this study, including 882 cancer patients. The results showed that patients with increased MNX-AS1 expression were more likely to develop lymph node metastasis (OR = 5.616, 95%CI: 3.093 - 10.199, P = 0.000) and advanced TNM stage (OR = 4.625, 95%CI: 2.366-9.040, P = 0.000). Moreover, we demonstrated that patients with high expression of MNX1-AS1 had poor OS in different cancers (HR = 1.976, 95%CI: 1.653 - 2.361, P=0.000). In addition, patients with high expression of MNX1-AS1 suffer from worse prognosis in gastric cancer (HR = 2.385, 95% CI: 1.838 - 3.094, P = 0.000) and lung cancer (HR= 1.959, 95%CI: 1.353 - 2.835, P = 0.000). Conclusions: High MNX1-AS1 expression is significantly associated with unfavorable clinical outcomes and it has the potential to serve as a prognostic biomarker in cancer patients.

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“…One important lncRNA, MNX1-AS1, was upregulated and involved in tumorigenesis of diverse malignant tumors, including non-small cell lung cancer (NSCLC) 35 , lung adenocarcinoma 36 , and Esophageal squamous cell carcinoma (ESCC) 37 . It was revealed that MNX1-AS1 was related to TNM stage and lymph node metastasis in NSCLC, and associated with a poor prognosis of NSCLC patients 35 . MNX1-AS1 expression was demonstrated to correlate with the poor prognosis of lung adenocarcinoma patients 36 .…”

Section: Discussionmentioning

confidence: 99%

“…Although the abnormal expression of some lncRNAs in ICC samples is a well-confirmed phenomenon, the functional mechanisms of lncRNAs remain to be elucidated. One important lncRNA, MNX1-AS1, was upregulated and involved in tumorigenesis of diverse malignant tumors, including non-small cell lung cancer (NSCLC) 35 , lung adenocarcinoma 36 , and Esophageal squamous cell carcinoma (ESCC) 37 . It was revealed that MNX1-AS1 was related to TNM stage and lymph node metastasis in NSCLC, and associated with a poor prognosis of NSCLC patients 35 .…”

Section: Discussionmentioning

confidence: 99%

LncRNA MNX1-AS1 promotes progression of intrahepatic cholangiocarcinoma through the MNX1/Hippo axis

Chen

Xue

et al. 2020

Cell Death Dis

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Long non-coding RNAs (lncRNAs) have extremely complex roles in the progression of intrahepatic cholangiocarcinoma (ICC) and remain to be elucidated. By cytological and animal model experiments, this study demonstrated that the expression of lncRNA MNX1-AS1 was remarkably elevated in ICC cell lines and tissues, and was highly and positively correlated with motor neuron and pancreas homeobox protein 1 (MNX1) expression. MNX1-AS1 significantly facilitated the proliferation, migration, invasion, and angiogenesis in ICC cells in vitro, and remarkably promoted tumor growth and metastasis in vivo. Further study revealed that MNX1-AS1 promoted the expression of MNX1 via recruiting transcription factors c-Myc and myc-associated zinc finger protein (MAZ). Furthermore, MNX1 upregulated the expression of Ajuba protein via binding to its promoter region, and subsequently, Ajuba protein suppressed the Hippo signaling pathway. Taken together, our results uncovered that MNX1-AS1 can facilitate ICC progression via MNX1-AS1/c-Myc and MAZ/MNX1/Ajuba/Hippo pathway, suggesting that MNX1-AS1 may be able to serve as a potential target for ICC treatment.

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<p>Expression and significance of LncRNA MNX1-AS1 in non-small cell lung cancer</p>

Cited by 16 publications

References 20 publications

Long Non-Coding RNA MNX1-AS1 Promotes Progression of Triple Negative Breast Cancer by Enhancing Phosphorylation of Stat3

Long Non-Coding RNA MNX1-AS1 Promotes Progression of Triple Negative Breast Cancer by Enhancing Phosphorylation of Stat3

The prognostic utility and clinical outcomes of MNX1-AS1 expression in cancers: a systematic review and meta-analysis

LncRNA MNX1-AS1 promotes progression of intrahepatic cholangiocarcinoma through the MNX1/Hippo axis

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