<p>Feasibility and efficacy of enhanced recovery after surgery protocol in Chinese elderly patients with intracranial aneurysm</p>

Abstract

ObjectiveIntracranial aneurysm is a kind of severe intracranial disease mainly responsible for subarachnoid hemorrhage, and the rupture of intracranial aneurysm results in a mortality rate of 30%–40%. For the first time in the world, this study aimed to assess the feasibility and efficacy of enhanced recovery after surgery (ERAS) protocol in Chinese elderly patients with intracranial aneurysm.MethodsIn this study, 300 elderly patients with intracranial aneurysm were recruited and divided into two groups as follows: ERAS group (n=150, ERAS protocol) and control group (n=150, conventional management).ResultsAge of whole cohort was 65 (64–67) years with 140 males (46.7). There was no difference between two groups in baseline features of patients, such as age, sex, medical histories, percentages of aneurysmal location, aneurysmal number >1 per patient, aneurysmal diameter >5 mm, or lobular aneurysm (P>0.05 for all). There was no occurrence of death in two groups. Compared with those in the control group, patients in the ERAS group had significantly shorter length of hospital stay (P<0.05). Between two groups, patients had not only similar Glasgow Outcome Scale (GOS) and Modified Rankin Scale (MRS) at discharge but also occurrence of readmission at follow-up (P>0.05 for all). Patients in the ERAS group had significantly higher GOS and lower MRS at follow-up (P<0.05 for all).ConclusionERAS protocol significantly shortened the length of hospital stay and improved GOS and MRS without any increase in the mortality or readmission in Chinese elderly patients with intracranial aneurysm.

RETRACTED ARTICLE: Long Non-coding RNA MALAT1/microRNA-143/VEGFA Signal Axis Modulates Vascular Endothelial Injury-Induced Intracranial Aneurysm

“…IA is a serious intracranial disease, which mainly leads to subarachnoid hemorrhage [18]. A previous study has demonstrated the involvements of lncRNA-related competitive endogenous RNA networks in IA [19].…”

RETRACTED ARTICLE: Restored microRNA-133a-3p or Depleted PSAT1 Restrains Endothelial Cell Damage-Induced Intracranial Aneurysm Via Suppressing the GSK3β/β-Catenin Pathway

“…Endovascular coiling or microsurgical clipping have been utilized to prevent future rupture of unruptured aneurysm in patients with high risk of rupture [4]. Although significant progress has been made in IA surgical operation, poor post-operative recovery is still presented in IA patients [5]. The tough situation of IA treatment makes it necessary to further explore the mechanism and find a new therapeutic strategy.…”

Enhanced Recovery After Surgery (ERAS) for Patients Undergoing Craniotomy: A Systematic Review

“…Subsequently, various authors have assessed ERAS protocols in patients undergoing craniotomy for varied pathologies. [4][5][6][7] We conducted a systematic review to examine evidence of advantages of ERAS protocols compared with conventional management in patients undergoing craniotomy. This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines; full details of the search strategy and article screening are available in the Supplementary Material (Supplemental Digital Content 1: PRISMA flowchart, http://links.lww.com/JNA/A359; Supplemental Digital Content 2: Details of search strategy, http://links.lww.com/JNA/A360).…”

“…After removal of duplicates, 97 records were screened of which 93 were excluded because they were not RCTs. Of the 4 studies that met the original inclusion criteria, [4][5][6][7] one study 4 was subsequently retracted 8 and therefore excluded, leaving 3 studies available for qualitative analysis (Supplemental Digital Content 1: PRISMA flowchart, http://links.lww.com/ JNA/A359). Continuous data were converted to the mean difference using the inverse variance method and an overall mean difference was calculated.…”

“…The knowledge gap identified by Hagan’s protocol was an absence of good quality randomized controlled trials (RCTs) investigating ERAS in craniotomy patients. Subsequently, various authors have assessed ERAS protocols in patients undergoing craniotomy for varied pathologies 4–7. We conducted a systematic review to examine evidence of advantages of ERAS protocols compared with conventional management in patients undergoing craniotomy.…”