Collective food toxiinfections (CFTI) are frequent accidents, formidable by their health and economic consequences. They usually result from the consumption of food contaminated with microorganisms or chemical toxins. The objective of our study is to evaluate the knowledge, attitudes and practices of food product handlers in Kloto 1 municipality in order to guarantee food safety. To do this, we carried out a survey using google form whose questions were based on knowledge of foodborne diseases, good hygiene practices, good manufacturing practices, cross-contamination, wearing jewelry during handling, waste management. As a result of the study, It shows that during the years 2018, 2019 and 2020, the frequencies of toxiinfections recorded at the PHC of Kpalimé are respectively 33.09%, 41.84%, and 25.06%. To acces risk factor about this hight case of food poissoning in this area, 197 food handlers (FH) were interviewed and of these, 54.4% were women, 51.3% are between 15 and 25 years old, 67.2% have secondary education, and 68.7% have not received training on food safety. In terms of the level of knowledge, attitudes and practices, 10.7% of FH have insufficient knowledge about food safety, 98.0% have negative attitudes and 100.0% have insufficient food safety practices. Also, it shown that there is a strong positive correlation between knowledge and attitudes (rs = 0,267; p= 0.000), between knowledge and practices (rs = 0.182; p = 0.011), between attitudes and practices (rs = 0.253; p = 0.000), and between knowledge about foodborne illness and practice (rs = 0.189; p = 0,008). In short, the majority of FH have insufficient knowledge, practice and negative attitudes to avoid cases of CFTI because of the lack of training in food safety.