&lt;p&gt;Gene Expression Profiling of the Liver and Lung in Mice After Exposure to ZnO Quantum Dots&lt;/p&gt;

Yang, Yanjie; Li, Peisen; Lin, Yao; Li, Ziqi; Cui, Tianyi; Song, Zhenhua; Wu, Weixia; Lv, Shuangyu; Ji, Shaoping

doi:10.2147/ijn.s246754

Cited by 7 publications

(5 citation statements)

References 25 publications

(32 reference statements)

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“…Yang et al, found that 218 genes were significantly differentially expressed in the lung after ZnO QDs treatment by RNA sequencing. Related signaling and pathways mainly included cell DNA replication, peroxisome proliferator-activated receptor (PPAR) signaling, retinol metabolism, p53 signaling pathway and cellular senescence ( 55 ).…”

Section: Toxicities Of Qds In Lungmentioning

confidence: 99%

Applications and Immunological Effects of Quantum Dots on Respiratory System

et al. 2022

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Quantum dots (QDs), are one kind of nanoscale semiconductor crystals with specific electronic and optical properties, offering near-infrared mission and chemically active surfaces. Increasing interest for QDs exists in developing theranostics platforms for bioapplications such as imaging, drug delivery and therapy. Here we summarized QDs’ biomedical applications, toxicity, and immunological effects on the respiratory system. Bioapplications of QDs in lung include biomedical imaging, drug delivery, bio-sensing or diagnosis and therapy. Generically, toxic effects of nanoparticles are related to the generation of oxidative stresses with subsequent DNA damage and decreased lung cells viability in vitro and in vivo because of release of toxic metal ions or the features of QDs like its surface charge. Lastly, pulmonary immunological effects of QDs mainly include proinflammatory cytokines release and recruiting innate leukocytes or adaptive T cells.

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Section: Toxicities Of Qds In Lungmentioning

confidence: 99%

Applications and Immunological Effects of Quantum Dots on Respiratory System

et al. 2022

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“…In recent years, in vivo studies have shown that QDs can cause liver inflammation accompanied by liver damage (Yang et al, 2020).…”

Section: Liver Toxicitymentioning

confidence: 99%

Toxicity of quantum dots on target organs and immune system

Zhang

Tang

2021

J of Applied Toxicology

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Quantum dots (QDs), due to their superior luminous properties, have been proven to be a very promising biological probe, which can be used as a candidate material for clinical applications. The toxicity of QDs in the environment and biological systems has caused widespread concern in the nanosphere, but their immune toxicity and their impact on the immune system are still relatively unknown. At present, the research on the toxicity of QDs is mainly focused on in vitro models, but few have systematically evaluated their adverse effects on target organs. Animal studies have shown that QDs can be accumulated in various organs due to their main exposure routes, thereby posing a potential threat to major organs. This review briefly describes general characteristics and the wide medical applications of QDs and focuses on the adverse effects of QDs on major target organs, such as liver, lung, kidney, brain, and spleen, after acute and chronic exposure. QDs mainly cause changes in the corresponding indicators of target organs, such as oxidative damage, and in severe cases cause hyperemia, tissue necrosis, and even death. In addition to causing direct damage to target organs, QDs can also cause a large number of immune cells to accumulate and cause inflammatory reactions when causing damage to other major organs. Whether it is to avoid the risk of people contacting QDs in production and life, or to realize the clinical applications of QDs, is very essential to conduct systematic in vivo toxicity assessment of QDs.

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“…The liver is an important organ of metabolic clearance and a major site of ZnO QDs accumulation. 24 , 25 To investigate the toxicity of ZnO QDs, we selected the human SMMC-7721 cell line, which is commonly used in in vitro models to elucidate cytotoxicity mechanisms on hepatocytes. 26 We first utilized a multi-omics (proteomics and metabolomics) approach to gain more information and better understand the nanotoxicity of ZnO QDs.…”

Section: Introductionmentioning

confidence: 99%

Proteomics and Metabolomics Analysis Reveals the Toxicity of ZnO Quantum Dots on Human SMMC-7721 Cells

Yang¹,

Wang²,

Song³

et al. 2023

IJN

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Purpose ZnO quantum dots (QDs) are composed of less toxic metals than other QDs but have the same interesting photochemical properties. Thus, they have received considerable attention recently. Nevertheless, their toxicity cannot be ignored. Methods In this study, we incubated ZnO QDs with human SMMC-7721 cells for 24 h to assess their nanotoxicity through proteomics (Fold change >1.5 and p -value <0.05) and metabolomics (Fold change ≥ 1.5; VIP ≥ 1; p -value < 0.05) analyses. Results Both of 174 and 219 significantly changed metabolites were identified in human SMMC-7721 cells treated with 20 and 50 µg/mL ZnO QDs, respectively. ZnO QDs significantly modified metabolic pathways, including purine metabolism, ferroptosis, morphine addiction, alcoholism, cGMP-PKG signaling, and Cushing syndrome. Moreover, we identified 105 and 8 differentially expressed proteins in cells treated with 20 and 50 µg/mL ZnO QDs, and the pathways of alcoholism and Cushing syndrome were enriched. Conclusion ZnO QDs did not affect cell viability in a CCK8 assay, but disturbed the level of intracellular metabolites and proteins at 20 µg/mL. The KEGG analyses of the metabolomics and proteomics data both enriched the alcoholism and Cushing syndrome pathways. These results provide an experimental basis for future research on the safe use of nanomaterials.

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<p>Gene Expression Profiling of the Liver and Lung in Mice After Exposure to ZnO Quantum Dots</p>

Cited by 7 publications

References 25 publications

Applications and Immunological Effects of Quantum Dots on Respiratory System

Applications and Immunological Effects of Quantum Dots on Respiratory System

Toxicity of quantum dots on target organs and immune system

Proteomics and Metabolomics Analysis Reveals the Toxicity of ZnO Quantum Dots on Human SMMC-7721 Cells

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