&lt;p&gt;GLP-1 mediates the modulating effect of thymoquinone on feeding behaviors in diabetic rats&lt;/p&gt;

Lee, Shu Ping; Kuo, Feng Yu; Wu, Ming Chang

doi:10.2147/dmso.s207596

Cited by 5 publications

(4 citation statements)

References 45 publications

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“…Insulin secretion is affected by a variety of factors. NS can increase insulin secretion by increasing GLP1 secretion [46,47], stimulating beta-adrenergic receptors [48], proliferating and regenerating pancreatic beta cells [49,50], and decreasing serum glucagon [51,52]. In addition, black seed can increase the sensitivity of insulin receptors by increasing the production of p-IRS and p-AKT and decreasing leptin secretion [32,53].…”

Section: Discussionmentioning

confidence: 99%

Effect of Nigella Sativa Oil on Oxidative Stress, Inflammatory, and Glycemic Control Indices in Diabetic Hemodialysis Patients: A Randomized Double-Blind, Controlled Trial

Rahmani

Niknafs

Naseri

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background and Aims. Diabetes is a leading cause of renal failure. High levels of oxidative stress and inflammation in patients with renal diabetes lead to various disorders and mortality. This study was performed to determine the effect of Nigella sativa (NS) supplementation on superoxide dismutase (SOD), malondialdehyde (MDA), total antioxidant capacity (TAC), high-sensitivity C-reactive protein (hs-CRP), glycosylated hemoglobin (HbA1c), fasting blood sugar (FBS), and insulin (INS) in patients with diabetes mellitus undergoing hemodialysis (HD). Methods. In this randomized, double-blind, placebo-controlled clinical trial, a total of 46 diabetic HD patients were randomly divided into NS (n = 23) and placebo (n = 23) groups. NS group received 2 g/day of NS oil, and the placebo group received paraffin oil for 12 weeks. Serum levels of SOD, MDA, TAC, hs-CRP, HbA1C, FBS, and INS were measured before and after the study. Results. Compared to baseline values, SOD, TAC, and INS levels increased, whereas MDA, hs-CRP, HbA1c, and FBS significantly decreased. After adjusting for covariates using the ANCOVA test, changes in the concentrations of SOD (p = .040), MDA (p = .025), TAC (p=<.001), hs-CRP (p = .017), HbA1c (p = .014), and FBS (p = .027) were statistically significant compared to the placebo group. Intergroup changes in INS were not significant. Additionally, there were no notable side effects during the research. Conclusions. This study found that NS supplementation significantly enhanced the levels of SOD, MDA, TAC, hs-CRP, HbA1c, and FBS in diabetic HD patients.

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Section: Discussionmentioning

confidence: 99%

Effect of Nigella Sativa Oil on Oxidative Stress, Inflammatory, and Glycemic Control Indices in Diabetic Hemodialysis Patients: A Randomized Double-Blind, Controlled Trial

Rahmani

Niknafs

Naseri

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Researchers reported that administration of 50 and 100 mg/kg/day of TQ could reduce the level of glucose, HOMA-IR, and food and water intake in diabetic rats. These effects of TQ were carried out through enhancing the endogenous level of glucagon-like peptide 1 ( Lee et al, 2019 ).…”

Section: The Effects Of Medicinal Plants On Metabolic Disordersmentioning

confidence: 99%

Effects of Nigella sativa, Camellia sinensis, and Allium sativum as Food Additives on Metabolic Disorders, a Literature Review

2021

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Objective: Metabolic disorders (MD) can disturb intracellular metabolic processes. A metabolic disorder can be resulted from enzyme deficits or disturbances in function of various organs including the liver, kidneys, pancreas, cardiovascular system, and endocrine system. Some herbs were used traditionally for spices, food additives, dietary, and medicinal purposes. Medicinal plants possess biological active compounds that enhance human health. We aimed to provide evidence about therapeutic effects of some medicinal herbs on MD.Data Sources: PubMed, Scopus, and Google Scholar were explored for publications linked to MD until February 2021. The most literature reports that were published in the last 10 years were used. All types of studies such as animal studies, clinical trials, and in vitro studies were included. The keywords included “Metabolic disorders,” “Nigella sativa L.,” “Thymoquinone,” “White tea”OR “Camellia sinensis L.” “catechin,” and “Allium sativum L.” OR “garlic” were searched.Results: Based on the results of scientific studies, the considered medicinal plants and their active components in this review have been able to exert the beneficial therapeutic effects on obesity, diabetes mellitus and non-alcoholic fatty liver disease.Conclusions: These effects are obvious by inhibition of lipid peroxidation, suppression of inflammatory reactions, adjustment of lipid profile, reduction of adipogenesis and regulation of blood glucose level.

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“…Thymoquinone being potent anticancer agent significantly lowers the hypoxia‐inducible factor‐1α (HIF‐1α) expression, inhibits interaction between HSP90 and HIF‐1α, and boosts HIF‐1α protein degradation in hypoxic cancer cells. It also suppresses the downstream genes of HIF‐1α, exhibited alterations in concentrations of lactate, glucose, and ATP levels, which further linked with disturbance of anaerobic metabolic and induction of apoptosis (Lee, Kuo, et al, 2019; Lee, Kim, et al, 2019). Thymoquinone also suppresses the cancer cell stages and the activation of PI3K/Akt pathway in oral squamous cell carcinoma (Ren & Luo, 2019).…”

Section: Health Perspectivesmentioning

confidence: 99%

“…Glucagon‐like peptide‐1 (GLP‐1) analogs have been found to improve the glycemic control, while administration of streptozotocin is used to induce the diabetes in experimental subjects. In diabetic rats, supplementation of thymoquinone by using oral route in dose‐dependent manner exhibited elevation in plasma GLP‐1 levels by lowering the hypergaphy (Harphoush et al., 2019; Lee et al, 2019; Lee, Kim, et al, 2019). In diet‐induced obesity mouse model, supplemented thymoquinone at the rate of 20 mg/kg BW per day prevented diabetic phenotype via lowering the glucose concentration, fasting insulins, serum cholesterol, triglycerides, and inflammatory markers resistin and MCP‐1, improving the glucose tolerance and insulin sensitivity, and enhancing the phosphorylated Akt level, whereas it phosphorylated SIRT‐1 in skeletal muscle and phosphorylated SIRT‐1 and AMPKα in liver (Shpetim et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic perspective of thymoquinone: A mechanistic treatise

Butt¹,

Imran

et al. 2021

Food Science & Nutrition

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The higher utilization of fruits and vegetables is well known to cure human maladies due to the presence of bioactive components. Among these compounds, thymoquinone, a monoterpene and significant constituent in the essential oil of Nigella sativa L., has attained attention by the researchers due to their pharmacologies perspectives such as prevention from cancer, antidiabetic and antiobesity, prevention from oxidative stress and cardioprotective disorder. Thymoquinone has been found to work as anticancer agent against different human and animal cancer stages including propagation, migration, and invasion. Thymoquinone as phytochemical also downregulated the Rac1 expression, mediated the miR‐34a upregulation, and increased the levels of miR‐34a through p53, as well as also regulated the pro‐ and antiapoptotic genes and decreased the phosphorylation of NF‐κB and IKKα/β. In addition, thymoquinone also lowered the metastasis and ERK1/2 and PI3K activities. The present review article has been piled by adapting narrative review method and highlights the diverse aspects of thymoquinone such as hepatoprotective, anti‐inflammatory, and antiaging through various pathways, and further utilization of this compound in diet has been proven effective against different types of cancers.

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<p>GLP-1 mediates the modulating effect of thymoquinone on feeding behaviors in diabetic rats</p>

Cited by 5 publications

References 45 publications

Effect of Nigella Sativa Oil on Oxidative Stress, Inflammatory, and Glycemic Control Indices in Diabetic Hemodialysis Patients: A Randomized Double-Blind, Controlled Trial

Effect of Nigella Sativa Oil on Oxidative Stress, Inflammatory, and Glycemic Control Indices in Diabetic Hemodialysis Patients: A Randomized Double-Blind, Controlled Trial

Effects of Nigella sativa, Camellia sinensis, and Allium sativum as Food Additives on Metabolic Disorders, a Literature Review

Therapeutic perspective of thymoquinone: A mechanistic treatise

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