<p>Grape seed procyanidin B2 promotes the autophagy and apoptosis in colorectal cancer cells via regulating PI3K/Akt signaling pathway [Corrigendum]</p>

Ganoderma lucidum Polysaccharide Enzymatic Hydrolysate Suppresses the Growth of Human Colon Cancer Cells via Inducing Apoptosis

“…The previous study has indicated that the improvement in triggering of the mitochondrial pathway by cyclophosphamide might be associated with the effects of GLP on the regulation of Bcl-2 family proteins 27 , which reminded us to speculate that EGLP may promote HCT-116 cells apoptosis via the regulation of Bax/Bcl-2 protein expression. Lots of reports have indicated that both mitogen-activated protein kinase/extracellular regulated protein kinases (MAPK/ERK) and phosphatidylinositol -3- hydroxykinase (PI3K/Akt) are representative signaling pathways and have been previously indicated to be activated in various types of tumors or cells, including colorectal cancer 28,29 . Besides, the overexpression of the PI3K/Akt signaling pathway facilitates the depolymerization of Bcl-xl and Bcl-2, resulting in the inactivation of Caspase-9 and Caspase-3, and finally leads to the growth and proliferation of cancer cells 29 .…”

“…Lots of reports have indicated that both mitogen-activated protein kinase/extracellular regulated protein kinases (MAPK/ERK) and phosphatidylinositol -3- hydroxykinase (PI3K/Akt) are representative signaling pathways and have been previously indicated to be activated in various types of tumors or cells, including colorectal cancer 28,29 . Besides, the overexpression of the PI3K/Akt signaling pathway facilitates the depolymerization of Bcl-xl and Bcl-2, resulting in the inactivation of Caspase-9 and Caspase-3, and finally leads to the growth and proliferation of cancer cells 29 . An accumulation of reports indicated that the activation of COX-2 in various types of tumors is related to the progression of the malignant tumor.…”