<p>Human Platelets and Derived Products in Treating Ocular Surface Diseases – A Systematic Review</p>

Abstract

Human platelet products have emerged as an alternative treatment for a range of ocular surface diseases such as dry eye and corneal ulceration. With significant therapeutic potential and increasing popularity, this study aimed to conduct a systematic review to detail the various production methods involved in generating platelet-derived products, compare and analyze clinical findings across available studies, and disseminate the relative advantages, limitations, and challenges of using platelet products to treat ocular surface disease. Thirty-eight clinical studies were identified, excluding studies conducted in animals and non-English language. Studies reported clinical outcomes, which included ocular surface disease index, best-corrected visual acuity, and corneal fluorescein staining. Most clinical studies reported improved patient signs and symptoms with an increasing variety of human platelet products including platelet rich plasma eye drops, human platelet lysate and platelet gels. However, due to variations in production methods, and study designs as well as confusing terminology, it was suggested that characterization of platelet products is needed for proper evaluation across studies.

Corneal Ulcer in Dogs and Cats: Novel Clinical Application of Regenerative Therapy Using Subconjunctival Injection of Autologous Platelet-Rich Plasma

“…In human literature, there was a split between studies that deployed comparison arm ( 88 – 90 ); other reports did not deploy a comparison arm ( 11 , 84 , 91 , 92 ). In a recent systematic review conducted by You et al ( 93 ), they analyzed the results of 35 clinical studies that dealt with different ocular diseases and utilized platelet products as line of therapy, under corneal ulcer in their table description. They reported 16 studies that deployed PRP in treating different corneal ulcers: six studies used comparison arms and 10 studies did not utilize/report involvement of comparison group.…”

New Pharmacological Approaches for the Treatment of Neurotrophic Keratitis

“…Platelet rich plasma (PRP) and plasma rich in growth factors (PRGF) have been reported to be effective for promoting resolution of persistent epithelial defects which are unresponsive to conventional treatments ( You et al, 2020 ). It contains a number of growth factors such as platelet-derived growth factor (PDGF), EGF, fibroblast growth factor (FGF), TGF, nerve growth factor (NGF), and insulin-like growth factor (IGF).…”

Cell and Cell Free Therapies in Osteoarthritis

“…PRP has emerged as an alternative treatment for some ocular surface diseases, such as dry eye and corneal ulceration, with significant therapeutic potential [ 225 ].…”