&lt;p&gt;Hydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications&lt;/p&gt;

Doostmohammadi, Mohsen; Ameri, Atefeh; Mohammadinejad, Reza; Dehghannoudeh, Negar; Banat, Ibrahim M.; Ohadi, Mandana; Dehghannoudeh, Gholamreza

doi:10.2147/dddt.s217211

Cited by 33 publications

(32 citation statements)

References 114 publications

(123 reference statements)

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“…Iturin was shown to pass through the cell wall and disrupt the plasma membrane with the formation of small vesicles and the aggregation of intramembranous particles, interacting with the nuclear membrane and probably with membranes of other cytoplasmic organelles affecting the morphology and membrane structure of yeast cells (Thimon et al 1995 ). Recently, the studies in molecular surfactant-like peptides and lipids has become more focused and significant due to their excellent properties, such as versatility, biocompatibility and medicinal properties (Cui et al 2010 ; Hosseinkhani et al 2013 ; Dehsorkhi et al 2014 ; Du and Stenzel 2014 ; Malaspina et al 2017 ; Doostmohammadi et al 2019 ).…”

Section: Surfactant–lipid Interactionsmentioning

confidence: 99%

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Surfactants: physicochemical interactions with biological macromolecules

et al. 2021

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Macromolecules are essential cellular components in biological systems responsible for performing a large number of functions that are necessary for growth and perseverance of living organisms. Proteins, lipids and carbohydrates are three major classes of biological macromolecules. To predict the structure, function, and behaviour of any cluster of macromolecules, it is necessary to understand the interaction between them and other components through basic principles of chemistry and physics. An important number of macromolecules are present in mixtures with surfactants, where a combination of hydrophobic and electrostatic interactions is responsible for the specific properties of any solution. It has been demonstrated that surfactants can help the formation of helices in some proteins thereby promoting protein structure formation. On the other hand, there is extensive research towards the use of surfactants to solubilize drugs and pharmaceuticals; therefore, it is evident that the interaction between surfactants with macromolecules is important for many applications which includes environmental processes and the pharmaceutical industry. In this review, we describe the properties of different types of surfactants that are relevant for their physicochemical interactions with biological macromolecules, from macromolecules–surfactant complexes to hydrophobic and electrostatic interactions.

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Section: Surfactant–lipid Interactionsmentioning

confidence: 99%

“…Stage II: Combination of micelles and lipid/surfactant aggregates. Stage III: Mixed micelles formation (Cui et al 2010;Hosseinkhani et al 2013;Dehsorkhi et al 2014;Du and Stenzel 2014;Malaspina et al 2017;Doostmohammadi et al 2019).…”

Section: Surfactant-lipid Interactionsmentioning

confidence: 99%

Surfactants: physicochemical interactions with biological macromolecules

et al. 2021

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“…CS is a water-soluble cationic polysaccharide with a positive charge and biocompatible and biodegradable characteristics [245,246]. The nonallergenic and nontoxic characteristics of CS make it an appropriate choice for delivery systems in pharmaceutical applications [247][248][249].…”

Section: Chitosan (Cs)mentioning

confidence: 99%

Multifunctional Polymeric Nanoplatforms for Brain Diseases Diagnosis, Therapy and Theranostics

et al. 2020

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The blood–brain barrier (BBB) acts as a barrier to prevent the central nervous system (CNS) from damage by substances that originate from the blood circulation. The BBB limits drug penetration into the brain and is one of the major clinical obstacles to the treatment of CNS diseases. Nanotechnology-based delivery systems have been tested for overcoming this barrier and releasing related drugs into the brain matrix. In this review, nanoparticles (NPs) from simple to developed delivery systems are discussed for the delivery of a drug to the brain. This review particularly focuses on polymeric nanomaterials that have been used for CNS treatment. Polymeric NPs such as polylactide (PLA), poly (D, L-lactide-co-glycolide) (PLGA), poly (ε-caprolactone) (PCL), poly (alkyl cyanoacrylate) (PACA), human serum albumin (HSA), gelatin, and chitosan are discussed in detail.

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“…We chose hydrogels commonly used for pharmaceutical compounding, which can provide a form of therapy available to every patient, i.e., Carbopol ® UltrezTM 10, Carbopol ® UltrezTM 30 hydrogel based on methyl cellulose and glycerol ointment. We selected carriers that are promising for clinical applications [ 22 , 23 ]. Their advantages include simple production technology, low financial costs associated with their preparation, high efficiency, high biocompatibility, low sensitizing potential, and an esthetic and modern form of application.…”

Section: Introductionmentioning

confidence: 99%

Pre-Formulation Studies: Physicochemical Characteristics and In Vitro Release Kinetics of Insulin from Selected Hydrogels

et al. 2021

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Insulin loaded to the polymer network of hydrogels may affect the speed and the quality of wound healing in diabetic patients. The aim of our research was to develop a formulation of insulin that could be applied to the skin. We chose hydrogels commonly used for pharmaceutical compounding, which can provide a form of therapy available to every patient. We prepared different gel formulations using Carbopol® UltrezTM 10, Carbopol® UltrezTM 30, methyl cellulose, and glycerin ointment. The hormone concentration was 1 mg/g of the hydrogel. We assessed the influence of model hydrogels on the pharmaceutical availability of insulin in vitro, and we examined the rheological and the texture parameters of the prepared formulations. Based on spectroscopic methods, we evaluated the influence of model hydrogels on secondary and tertiary structures of insulin. The analysis of rheograms showed that hydrogels are typical of shear-thinning non-Newtonian thixotropic fluids. Insulin release from the formulations occurs in a prolonged manner, providing a longer duration of action of the hormone. The stability of insulin in hydrogels was confirmed. The presence of model hydrogel carriers affects the secondary and the tertiary structures of insulin. The obtained results indicate that hydrogels are promising carriers in the treatment of diabetic foot ulcers. The most effective treatment can be achieved with a methyl cellulose-based insulin preparation.

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<p>Hydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications</p>

Cited by 33 publications

References 114 publications

Surfactants: physicochemical interactions with biological macromolecules

Surfactants: physicochemical interactions with biological macromolecules

Multifunctional Polymeric Nanoplatforms for Brain Diseases Diagnosis, Therapy and Theranostics

Pre-Formulation Studies: Physicochemical Characteristics and In Vitro Release Kinetics of Insulin from Selected Hydrogels

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