&lt;p&gt;Identification of Novel Therapeutic Molecular Targets in Inflammatory Bowel Disease by Using Genetic Databases&lt;/p&gt;

Mohan, Sachin; Mok, Shaffer; Judge, Thomas A.

doi:10.2147/ceg.s264812

Cited by 7 publications

(3 citation statements)

References 34 publications

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“…Mohan et al [ 99 ] reported using genetic databases to find new molecular targets for IBD. They used four different genetic databases to categorize the protein-coding genes associated with UC (3783 genes), CD (3980 genes), uveitis (1043 genes), arthritis (5583 genes), primary sclerosing cholangitis (1313 genes), and pyoderma gangrenosum (119 genes).…”

Section: Role Of Computational Methods In Ibd Drug Discoverymentioning

confidence: 99%

Modern drug discovery for inflammatory bowel disease: The role of computational methods

Johnson¹,

Akinsanmi²,

Ejembi³

et al. 2023

World J Gastroenterol

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Inflammatory bowel diseases (IBDs) comprising ulcerative colitis, Crohn’s disease and microscopic colitis are characterized by chronic inflammation of the gastrointestinal tract. IBD has spread around the world and is becoming more prevalent at an alarming rate in developing countries whose societies have become more westernized. Cell therapy, intestinal microecology, apheresis therapy, exosome therapy and small molecules are emerging therapeutic options for IBD. Currently, it is thought that low-molecular-mass substances with good oral bio-availability and the ability to permeate the cell membrane to regulate the action of elements of the inflammatory signaling pathway are effective therapeutic options for the treatment of IBD. Several small molecule inhibitors are being developed as a promising alternative for IBD therapy. The use of highly efficient and time-saving techniques, such as computational methods, is still a viable option for the development of these small molecule drugs. The computer-aided ( in silico ) discovery approach is one drug development technique that has mostly proven efficacy. Computational approaches when combined with traditional drug development methodology dramatically boost the likelihood of drug discovery in a sustainable and cost-effective manner. This review focuses on the modern drug discovery approaches for the design of novel IBD drugs with an emphasis on the role of computational methods. Some computational approaches to IBD genomic studies, target identification, and virtual screening for the discovery of new drugs and in the repurposing of existing drugs are discussed.

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Section: Role Of Computational Methods In Ibd Drug Discoverymentioning

confidence: 99%

Modern drug discovery for inflammatory bowel disease: The role of computational methods

Johnson¹,

Akinsanmi²,

Ejembi³

et al. 2023

World J Gastroenterol

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“…Notably, the activities of the 3 key enzymes participating in the leukotriene pathway, namely, 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene A4 hydrolase, were markedly increased in the lesions of patients with active IBD, indicating that an elevated LTB4 release may contribute to neutrophil accumulation during IBD. 50 , 51 In addition, genetic depletion of 5-lipoxygenase or neutralization of 5-lipoxygenase with zileuton is associated with significant amelioration of experimental colitis. 52 Another arachidonic acid metabolite, hepoxilin A3 (HXA3), a well-known neutrophil chemotactic agent, is released from the apical surface of the epithelium to drive neutrophils to migrate across the epithelium into the gut lumen.…”

Section: The Intestinal Epithelium Recruits Neutrophils To Sites Of I...mentioning

confidence: 99%

Neutrophil–Epithelial Crosstalk During Intestinal Inflammation

Kang¹,

Fang²,

Song³

et al. 2022

Cellular and Molecular Gastroenterology and Hepatology

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“…There are also studies investigating the upstream regulation of IL-25. Though the IL-25 gene is located at 14q11.2 within the CD susceptibility locus [ 86 ] and was proved to be associated with CD and UC by analysis of genetic databases [ 87 ], no significant difference concerning its coding regions (c424C/A) was found between IBD patients and controls [ 86 ]. Thus, other factors involved in the transcription of IL-25 resulting in aberrant amounts of IL-25 in IBD patients have been further investigated.…”

Section: Introductionmentioning

confidence: 99%

Interleukin 25 and its biological features and function in intestinal diseases

Jiang¹,

Wang²,

Zhang³

et al. 2022

cejoi

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Interleukin 25 (IL-25), also known as IL-17E, is a member of the IL-17 cytokine family and an important regulator of the type 2 immune response. Accumulating evidence suggests that IL-25 interacts with diverse immune as well as non-immune cells and plays a rather complicated role in different backgrounds of multiple organs. IL-25 has been studied in the physiology and pathology of the intestine to some extent. With epithelial cells being an important source in the intestine, IL-25 plays a key role in intestinal immune responses and is associated with inappropriate allergic reactions, autoimmune diseases, and cancer tumorigenesis. In this review, we discuss the emerging comprehension of the biology of IL-25, as well as its cellular sources, targets, and signaling transduction. In particular, we discuss how IL-25 participates in the development of intestinal diseases including helminth infection, inflammatory bowel diseases, food allergy and colorectal cancer, as well as its underlying role in future therapy.

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<p>Identification of Novel Therapeutic Molecular Targets in Inflammatory Bowel Disease by Using Genetic Databases</p>

Cited by 7 publications

References 34 publications

Modern drug discovery for inflammatory bowel disease: The role of computational methods

Modern drug discovery for inflammatory bowel disease: The role of computational methods

Neutrophil–Epithelial Crosstalk During Intestinal Inflammation

Interleukin 25 and its biological features and function in intestinal diseases

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