&lt;p&gt;In vitro Evaluation of the Location of Cholesteryl Ester Deposits on Monthly Replacement Silicone Hydrogel Contact Lens Materials&lt;/p&gt;

Qiao, Han; Luensmann, Doerte; Heynen, Miriam; Drolle, Elizabeth; Subbaraman, Lakshman N.; Scales, Charles W.; Riederer, D. E.; Fadli, Zohra; Jones, Lyndon

doi:10.2147/opth.s270575

Cited by 5 publications

(5 citation statements)

References 37 publications

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“…Moreover, lens deposits are a plausible factor in increased contact lens discomfort, which varies based on the lens material. In an in vitro study, comfilcon A had a uniform lipid deposition profile on day 1 of incubation in an artificial tear solution; however, lotrafilcon B revealed more lipid deposition on the surface than in the core [ 16 ]. These two differences between comfilcon A and lotrafilcon B lenses may explain the significantly higher pain score on postoperative day 1 in eyes fitted with the latter lens.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the efficacy of lotrafilcon B and comfilcon A silicone hydrogel bandage contact lenses after transepithelial photorefractive keratectomy

Lotfy¹,

Alasbali²,

Gehedan³

et al. 2021

Med Hypothesis Discov Innov Ophthalmol

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Background: At completion of transepithelial photorefractive keratectomy (t-PRK) surgery, the eye is usually fitted with a bandage contact lens to reduce discomfort and promote epithelial healing. This study aimed to compare the outcomes of eyes fitted with lotrafilcon B versus comfilcon A, silicone hydrogel bandage contact lenses after t-PRK for the correction of low to moderate myopia, with or without astigmatism. Methods: In this comparative, prospective study, patients with myopia < -6 D with or without astigmatism (< 1.75 D), who underwent t-PRK between January and June 2018, were randomly allocated to the lotrafilcon B and comfilcon A groups. Preoperative characteristics, including age, sex, eye treated, uncorrected visual acuity (UCVA), best-corrected visual acuity, mesopic pupil size, central corneal thickness, and refractive error were recorded. Postoperatively, pain score, UCVA, and corneal epithelial defect size on days 1, 4, and 7 were compared between the two groups. Results: Twenty-nine eyes were included in each group. Demographic characteristics and preoperative measurements were similar between the two groups. UCVA was significantly improved on day 7 as compared to day 1 in the comfilcon A group (P = 0.03), but remained the same in the lotrafilcon B group (P = 0.70) as on day 1 postoperatively. There was no significant difference in UCVA between the two groups at any follow-up visits (all P > 0.05). The pain score on the first postoperative day was significantly higher in the lotrafilcon B-fitted eyes than in the comfilcon A group (P < 0.001), but was significantly reduced in both groups compared to day 1 (both P < 0.001). The epithelial defect in the comfilcon A group was significantly greater than in the lotrafilcon B group (P < 0.001) at day 1 postoperatively, with significant improvement in both groups (both P < 0.001). Conclusions: Healing responses were better with lotrafilcon B than with comfilcon A bandage contact lenses. The patients had a greater mean pain score with lotrafilcon B than with comfilcon A lenses on the first postoperative day, yet the final outcome was comparable between the two groups. We did not encounter any postoperative complications related to contact lens wear. How to cite this article: Lotfy NM, Alasbali T, Alsharif AM, Al-Gehedan SM, Jastaneiah S, Al-Hazaimeh A, Ali H, Khandekar R. Comparison of the efficacy of lotrafilcon B and comfilcon A silicone hydrogel bandage contact lenses after transepithelial photorefractive keratectomy. Med Hypothesis Discov Innov Ophthalmol. 2021 Summer; 10(2): 1-7. https://doi.org/10.51329/mehdiophthal1420

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Section: Discussionmentioning

confidence: 99%

Comparison of the efficacy of lotrafilcon B and comfilcon A silicone hydrogel bandage contact lenses after transepithelial photorefractive keratectomy

Lotfy¹,

Alasbali²,

Gehedan³

et al. 2021

Med Hypothesis Discov Innov Ophthalmol

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“…Amount of cholesterol (µg/lens) Example images of CE-NBD fluorescence profiles through senofilcon C (A), lotrafilcon B (B), comfilcon A (C), and samfilcon A (D) over 30 days [96].…”

Section: Figurementioning

confidence: 99%

“…Quantification of deposits high-performance liquid chromatography [16,43,79] thin layer chromatography [42,51,61,62,91] gas chromatography/mass spectrometry GC/MS [47] fluorescence spectroscopy [48,61] cholesterol esterase enzymatic reaction [53] fluorometric enzymatic assay [55,73,77,97] Visualization of deposits atomic force microscopy [46,80] fluorescence microscopy [64,84] fluorescence confocal scanning laser microscopy [87,93,96] optical microscopy [87] Methods used to evaluate lipids on lenses found in reviewed studies.…”

Section: Refsmentioning

confidence: 99%

“…Additionally, the research using fluorescence confocal scanning laser microscopy showed that after some time lipid deposits in the lens matrix reach a homogeneous distribution [96].…”

Section: Tablementioning

confidence: 99%

“…However, all materials exhibited a homogenous distribution after one month (fig. 6) [96]. The mean (± SD) total cholesterol uptake on various lens material when soaked and cleaned in saline and five different MPSs after 7 days of incubation in a complex tear solution containing radiolabeled 14 C-cholesterol ( * p = 0.05 for cleaned vs. uncleaned lenses).…”

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Interaction of silicone hydrogel contact lenses with lipids – a chronological review

Suliński

Pniewski

2020

Ophthatherapy

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Silicone hydrogel (Si-Hy) contact lenses are a common form of correction of refractive errors and are prescribed by eye care professionals around the world. Si-Hy lenses perform in a complex environment, which is the surface of the eye and the tear film. Therefore, they are exposed to various factors, such as lipid deposits. The aims of this paper are to review available scientific reports on the study of Si-Hy lens interactions with lipids and search for further research objectives. A total of 57 publications were identified and reviewed, from 2003 to 2020. In general, Si-Hy lenses are more likely to accumulate lipid deposits than traditional hydrogel lenses, although there are significant differences between Si-Hy lens materials that may result from different methods used in the studies. The review includes studies on various aspects of interactions between lenses and lipids, such as those concerning the effectiveness of lipids removal from lenses by care solutions. The conclusion points out future research directions, such as measurements of lipid diffusion in Si-Hy lens' matrices.

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Addressing common myths and misconceptions in soft contact lens practice

Walsh

Jones

Moody

2021

Clinical and Experimental Optometry

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<p>In vitro Evaluation of the Location of Cholesteryl Ester Deposits on Monthly Replacement Silicone Hydrogel Contact Lens Materials</p>

Cited by 5 publications

References 37 publications

Comparison of the efficacy of lotrafilcon B and comfilcon A silicone hydrogel bandage contact lenses after transepithelial photorefractive keratectomy

Comparison of the efficacy of lotrafilcon B and comfilcon A silicone hydrogel bandage contact lenses after transepithelial photorefractive keratectomy

Interaction of silicone hydrogel contact lenses with lipids – a chronological review

Addressing common myths and misconceptions in soft contact lens practice

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