<p>Inflammatory Marker Predicts Outcome of Oral Squamous Cell Carcinoma Receiving Chemo-Radiotherapy</p>

Abstract

Background: Inflammation is involved in the progression of oral squamous cell carcinoma. We therefore postulate that a blood-based inflammatory marker, the neutrophil-tolymphocyte ratio, could help to predict the prognosis in patients with oral squamous cell carcinoma receiving chemo-radiotherapy, and build a prognostic nomogram. Methods: In 111 cases of oral squamous cell carcinoma, several baseline variables, including inflammatory markers and lactate dehydrogenase, were measured within the week of chemoradiotherapy initiation as predictors of mortality and separate risk scores were developed. Results: Dichotomized neutrophil-to-lymphocyte ratio was found to be associated with AJCC stage (p<0.001). Patients with oral squamous cell carcinoma with a low neutrophil-tolymphocyte ratio survived longer than those with a high neutrophil-to-lymphocyte ratio (overall survival HR=2.39, 95% CI 1.24-4.61, p=0.009). The Harrell's concordance (C)-statistic of the nomogram was 0.74 and the calibration curve demonstrated the goodness of fit. Conclusion: The inflammatory marker neutrophil-to-lymphocyte ratio, obtained before chemo-radiotherapy, was an independent factor of survival prediction for oral squamous cell carcinoma. The nomogram incorporating immunological markers could more accurately predict individualized survival probability than the existing models. These findings are significant for the creation of personalized treatment strategies in the clinical setting.

Impact of Platelets to Lymphocytes Ratio and Lymphocytes during Radical Concurrent Radiotherapy and Chemotherapy on Patients with Nonmetastatic Esophageal Squamous Cell Carcinoma

“…When bone marrow suppression occurs, hematopoietic stem cells cannot produce adequate number of blood cells who have normal function, resulting in complications such as anemia, infection, and bleeding; these complications lower the survival of the patient severely. Several studies show that inflammation factors in the blood (for example, NLR, Journal of Oncology lymphocyte count, and neutrophil count) can predict the prognosis of patients with a variety of tumors [28][29][30][31]. Lymphocytes are related to host immunity.…”

Salivary Composition of Oral Squamous Cell Carcinoma Patients

“…Several authors have studied OSCC patients and found that LDH levels increase due to increased exfoliation of epithelial cells. 14 Cancerous cells express growth factors and MMPs to degrade type IV collagen fibres in the basement membrane. Stromal cells at the border of OSSC express these enzymes, and elevate levels are diagnostic.…”