&lt;p&gt;Keratograph 5M As A Useful And Objective Tool For Evaluating The Ocular Surface In Limbal Stem Cell Deficiency&lt;/p&gt;

Alfaro-Juárez, A.; Caro-Magdaleno, Manuel; Montero-Iruzubieta, Jesús; Fernández-Palacín, Ana; Muñoz-Morales, A.; Castilla-Martino, M.; Spínola-Muñoz, Consuelo; Rúa, Enrique Rodríguez de la

doi:10.2147/opth.s218313

Cited by 6 publications

(8 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 12-item Canadian Dry Eye Assessment (CDEA) questionnaire is a modification of the validated Ocular Surface Disease Index (OSDI), used to determine the severity of dry eye symptoms. 23,24 Total scores range from 0 to 48 and symptoms are interpreted as normal (<5), mild (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20), moderate (21)(22)(23)(24)(25)(26)(27)(28)(29)(30), or severe (31-48). 24 The question "How much do your eyes bother you?"…”

Section: Clinical Outcomesmentioning

confidence: 99%

Autologous Platelet‐Rich Plasma Drops for Evaporative Dry Eye Disease from Meibomian Gland Dysfunction: A Pilot Study

Murtaza¹,

Toameh²,

Chiu³

et al. 2022

OPTH

View full text Add to dashboard Cite

To evaluate the effects of autologous platelet-rich plasma (PRP) drops for evaporative dry eye (EDE) disease from meibomian gland dysfunction (MGD). Methods: This is a retrospective, consecutive case series of 20 eyes of 10 patients with EDE from MGD treated with PRP drops from November 2020 to November 2021 at a single outpatient clinic in Ontario, Canada. PRP drops were prepared from whole blood using a two-step centrifugation method. Patients were instructed to instill these drops six times daily for 4 weeks. The Canadian Dry Eye Assessment (CDEA) questionnaire score, patient subjective assessment (PSA) score, first and average non-invasive break-up times (f/a NIBUT), tear meniscus height (TMH), bulbar redness (BR), and meibograph grade (MG) were measured before and after the treatment course. Results: Significant improvements in dry eye symptoms and tear film parameters were observed. Dry eye symptoms significantly improved as per the CDEA (mean difference (MD) = −5.45, 95% confidence interval (CI) = [−7.9, −3.1], p<0.001) and PSA (MD = −2.6, 95% CI = [−3.9, −1.2], p<0.001). There were significant improvements in tear film parameters including fNIBUT (MD = 3.85s, 95% CI = [1.2, 6.8], p=0.006), aNIBUT (MD = −6.81s, 95% CI = [5.7, 11.1], p<0.001) and TMH (MD = 0.08, 95% CI = [0.003, 0.2], p=0.045). There was an improvement in conjunctival injection as measured by BR (MD = −0.36, 95% CI = [−0.4, −0.15], p=0.373). Five eyes experienced a one-grade improvement in MG (p=0.453), and none experienced worsening in MG with treatment. No temporary or permanent adverse effects were noted. Conclusion: Four weeks of PRP therapy resulted in significant functional improvements in dry eye symptoms and tear film quality and quantity. Improvements in conjunctival injection and microstructural improvements in meibomian glands were also observed in some eyes. Overall, PRP is a promising treatment option for patients with EDE from MGD refractory to conventional treatments.

show abstract

Section: Clinical Outcomesmentioning

confidence: 99%

Autologous Platelet‐Rich Plasma Drops for Evaporative Dry Eye Disease from Meibomian Gland Dysfunction: A Pilot Study

Murtaza¹,

Toameh²,

Chiu³

et al. 2022

OPTH

View full text Add to dashboard Cite

show abstract

“…The 12-item CDEA questionnaire is a modification of the validated Ocular Surface Disease Index (OSDI) used to determine the severity of dry eye symptoms. 27,28 Total scores range from 0 to 48 and symptoms are interpreted as normal (<5), mild (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20), moderate (21)(22)(23)(24)(25)(26)(27)(28)(29)(30), or severe (31-48). 28 The question "How much do your eyes bother you?"…”

Section: Patient-reported and Clinical Outcomesmentioning

confidence: 99%

“…A break-up time of ≤5 seconds suggests dry eyes. 30 The TMH is the distance between the darker edge of the lower eyelid and the tear strip. The final TMH was calculated from the average of the TMH measurements at the left, right and center of each eyelid.…”

Section: Patient-reported and Clinical Outcomesmentioning

confidence: 99%

“…Figure2Dry eye symptom severity according to the Canadian Dry Eye Assessment (CDEA) questionnaire before and after BBL-IPL therapy. Total scores for the CDEA questionnaire range from 0 to 48 and are interpreted as no dry eye symptoms or normal (<5), mild dry eye symptoms(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20), moderate dry eye symptoms(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), or severe dry eye symptoms(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Safety and Efficacy of BroadBand Intense Pulsed Light Therapy for Dry Eye Disease with Meibomian Gland Dysfunction

Murtaza¹,

Toameh²,

Al-Habib³

et al. 2021

OPTH

View full text Add to dashboard Cite

Background: BroadBand light intense pulsed light (BBL-IPL) therapy has shown to reduce hordeolum and blepharitis frequency. This study aims to evaluate the efficacy and safety of BBL-IPL therapy in patients with dry eye disease (DED) from meibomian gland dysfunction (MGD). Methods: This is a retrospective, consecutive case series of 48 patients with DED from MGD who underwent BBL-IPL therapy from October 2016 to January 2019 at a single, outpatient clinic in Ontario, Canada. Clinical outcomes included first and average noninvasive keratograph tear break-up times (NIKBUT), bulbar redness (BR) scores, tear meniscus heights (TMH), visual acuity (VA) and meibograph grades. Patient-reported outcomes included the Canadian dry eye assessment (CDEA) questionnaire and patient subjective assessment (PSA) scores. Outcomes were measured at baseline and after completion of 4 monthly BBL-IPL sessions. Results: The mean severity of dry eye symptoms as measured by the CDEA and PSA decreased significantly from 19.78 ± 9.62 to 12.08 ± 7.40 (p<0.001) and from 7.65 ± 1.74 to 4.77 ± 2.03 (p<0.001), respectively. Twenty-five percent of patients reported no dry eye symptoms after treatment. The meibograph grade improved significantly in both eyes (p<0.001). Approximately 71.0% and 80.1% of patients had an improved meibograph grade in the right and left eye, respectively. Near-significant improvements were observed for BR scores and VA. There was also a trend towards improved first/average NIKBUT and TMH scores. No adverse events were noted. Conclusion: BBL-IPL appears to be an effective and safe treatment modality in improving dry eye symptoms and meibomian gland function in patients with DED from MGD.

show abstract

“…Keratograph 5M (OCULUS Optikgeräte GmbH, Wetzlar, Germany) is a video topographer and a non-invasive, repeatable, and reproducible tool for the assessment of the ocular surface, allowing the analysis of different morpho-functional aspects. It combines corneal topography and dry eye study in a single tool and represents the gold standard for ocular surface investigation [ 13 , 14 , 15 , 16 , 17 , 18 ]. A series of studies has demonstrated the importance and effectiveness of Keratograph 5M (K5M) in the evaluation of ocular surface diseases, such as Dry Eye Disease (DED) and Meibomian Gland Dysfunction (MGD) [ 13 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Hi-Tech Devices in Assessment of Corneal Healing in Patients with Neurotrophic Keratopathy

Aragona

Wylęgała

Valastro

et al. 2022

JCM

View full text Add to dashboard Cite

To prove the role of high-tech investigation in monitoring corneal morphological changes in patients with neurotrophic keratopathy (NK) using Keratograph 5M (K5M) and anterior segment OCT (AS-OCT), corneal healing was monitored with Keratograph 5M (Oculus, Wetzlar, Germany) and AS-OCT (DRI, Triton, Topcon, Tokyo, Japan) in 13 patients (8F and 5M), aged from 24 to 93 years (67.8 ± 19) with severe NK, who were treated with Cenegermin 0.002% (20 μg/mL) (Oxervate®, Dompè, Farmaceutici Spa, Milan, Italy). The surface defects were evaluated on Keratograph 5M with ImageJ software and the corneal thickness variations were measured using DRI-Triton OCT software. Instrumental procedures were performed at baseline, and after 4 and 8 weeks of the treatment, respectively. The main outcome measures were reduction of the ulcers’ area and corneal thickness recovery. The mean area of the corneal ulcers was reduced between baseline and 4 weeks examination in all patients, and at 8 weeks all ulcers were completely healed. An increase of the corneal thickness was evidenced between the baseline visit and after the 4- and 8-week follow-up, respectively. Additionally, only in collaborating subjects the In Vivo Confocal Microscopy (IVCM) was performed with HRT Rostock Cornea Module (Heidelberg Eng GmbH) to study the corneal nerves fibres. High-tech diagnostics with K5M, AS-OCT and IVCM proved useful in the assessment of corneal morphology and the healing process in patients with NK and could be extended to assess other corneal pathologies.

show abstract

<p>Keratograph 5M As A Useful And Objective Tool For Evaluating The Ocular Surface In Limbal Stem Cell Deficiency</p>

Cited by 6 publications

References 27 publications

Autologous Platelet‐Rich Plasma Drops for Evaporative Dry Eye Disease from Meibomian Gland Dysfunction: A Pilot Study

Autologous Platelet‐Rich Plasma Drops for Evaporative Dry Eye Disease from Meibomian Gland Dysfunction: A Pilot Study

Safety and Efficacy of BroadBand Intense Pulsed Light Therapy for Dry Eye Disease with Meibomian Gland Dysfunction

The Role of Hi-Tech Devices in Assessment of Corneal Healing in Patients with Neurotrophic Keratopathy

Contact Info

Product

Resources

About