&lt;p&gt;Latest Advances of Long Non-Coding RNA SNHG5 in Human Cancers&lt;/p&gt;

Han, Wei; Shi, Jia; Cao, Jiachao; Dong, Bo; Guan, Wei

doi:10.2147/ott.s252750

Cited by 18 publications

(10 citation statements)

References 43 publications

(148 reference statements)

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“…Further investigation was undertaken to determine the effects of SNHG5 on the release of inflammatory factors, such as IL-1β, IL-6, TNF-α and IL-10. The results of the present study were consistent with previously reported findings ( 9 ). The majority of the studies of SNHG5 are in the field of human cancer, including gastric, breast, liver and esophageal cancer ( 17 – 21 ).…”

Section: Discussionsupporting

confidence: 94%

“…Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs that are >200 nucleotides in length and are involved in the regulation of several cellular processes ( 6 , 7 ), such as cell proliferation, apoptosis and differentiation, via regulating target gene expression ( 8 ). The lncRNA small nucleolar RNA host gene 5 (SNHG5) is a recently identified lncRNA that has yet to be extensively investigated, but has been found to be correlated with tumor range, metastasis, pathological stage and prognosis in various solid tumors ( 9 ). Moreover, SNHG5 has been indicated to play a key role in NP by sponging microRNA (miRNA/miR)-154-5p ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

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SNHG5 knockdown alleviates neuropathic pain induced by chronic constriction injury via sponging miR‑142‑5p and regulating the expression of CAMK2A

et al. 2022

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Neuropathic pain (NP) is one of the most intractable diseases. The lack of effective therapeutic measures remains a major problem due to the poor understanding of the cause of NP. The aim of the present study was to investigate the effect of the long non-coding RNA small nucleolar RNA host gene 5 (SNHG5) in NP and the underlying molecular mechanism in order to identify possible therapeutic targets. A chronic constriction injury (CCI) mouse model was used to investigate whether SNHG5 prevents NP and the inflammatory response. Luciferase and RNA pull-down assays were used to detect the binding between SNHG5 and miR-142-5p as well as between miR-142-5p and CAMK2A. Western blot and qPCR were used to detect the RNA and protein expression. The results indicated that SNHG5 significantly inhibited CCI-induced NP. In addition, SNHG5 inhibited the inflammatory response through decreasing the release and the mRNA expression of interleukin (IL)-1β, IL-6, IL-10 and tumor necrosis factor-α. Mechanistically, SNHG5 acted via sponging microRNA-142-5p, thereby upregulating the expression of calcium/calmodulin-dependent protein kinase II α (CAMK2A). Further investigation indicated that CAMK2A knockdown also inhibited CCI-induced NP and inflammation. In summary, the present study demonstrated that SNHG5 silencing could alleviate the neuropathic pain induced by chronic constriction injury via sponging miR-142-5p and regulating the expression of CAMK2A.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

SNHG5 knockdown alleviates neuropathic pain induced by chronic constriction injury via sponging miR‑142‑5p and regulating the expression of CAMK2A

et al. 2022

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“…Therefore, we speculated whether RBM47 could function by binding lncRNA. LncRNA SNHG5 has been elucidated to exhibit oncogenic property in various cancers [ 38 – 41 ]. In this study, SNHG5 was downregulated in PTC, and overexpression of SNHG5 inhibited PTC cells proliferation, but activated autophagy.…”

Section: Discussionmentioning

confidence: 99%

RBM47/SNHG5/FOXO3 axis activates autophagy and inhibits cell proliferation in papillary thyroid carcinoma

et al. 2022

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Papillary thyroid carcinoma (PTC) is the main type of thyroid carcinoma. Despite the good prognosis, some PTC patients may deteriorate into more aggressive diseases, leading to poor survival. Molecular technology has been increasingly used in the diagnosis and treatment of thyroid carcinoma. In this study, we identified that RNA Binding Motif Protein 47 (RBM47) was downregulated in PTC tissues and cells, and overexpression of RBM47 could activate autophagy and inhibit proliferation in PTC cells. RBM47 promotes but can not bind directly to Forkhead Box O3 (FOXO3). FOXO3 activates Autophagy Related Gene 3 (ATG3), ATG5, and RBM47 to form a loop and promote autophagy. RBM47 can bind directly to and stabilized lncRNA Small Nucleolar RNA Host Gene 5 (SNHG5) to inhibit PTC cells proliferation and activate autophagy in vitro and in vivo. SNHG5 inhibits ubiquitination and degradation of FOXO3 by recruiting Ubiquitin Specific Peptidase 21 (USP21), then promotes the translocation of FOXO3 from cytoplasm to nucleus. Our study revealed the regulatory mechanism of RBM47/SNHG5/FOXO3 axis on cell proliferation and autophagy in PTC, which may provide valuable insight for the treatment of PTC.

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“…SNHG5 was reported as a pro-oncogenic factor stimulating proliferation of myeloid leukemia cells [ 62 ]. High expression of two snoRNAs, SNORA72 and SNORA26 , was correlated with pro-oncogenic properties of cells and poor prognosis in cancer [ 63 , 64 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Transcriptomic Differences between Lower Extremities Arterial Disease, Abdominal Aortic Aneurysm and Chronic Venous Disease in Peripheral Blood Mononuclear Cells Specimens

Zalewski

Ruszel

Stępniewski

et al. 2021

IJMS

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Several human tissues are investigated in studies of molecular biomarkers associated with diseases development. Special attention is focused on the blood and its components due to combining abundant information about systemic responses to pathological processes as well as high accessibility. In the current study, transcriptome profiles of peripheral blood mononuclear cells (PBMCs) were used to compare differentially expressed genes between patients with lower extremities arterial disease (LEAD), abdominal aortic aneurysm (AAA) and chronic venous disease (CVD). Gene expression patterns were generated using the Ion S5XL next-generation sequencing platform and were analyzed using DESeq2 and UVE-PLS methods implemented in R programming software. In direct pairwise analysis, 21, 58 and 10 differentially expressed genes were selected from the comparison of LEAD vs. AAA, LEAD vs. CVD and AAA vs. CVD patient groups, respectively. Relationships between expression of dysregulated genes and age, body mass index, creatinine levels, hypertension and medication were identified using Spearman rank correlation test and two-sided Mann–Whitney U test. The functional analysis, performed using DAVID website tool, provides potential implications of selected genes in pathological processes underlying diseases studied. Presented research provides new insight into differences of pathogenesis in LEAD, AAA and CVD, and selected genes could be considered as potential candidates for biomarkers useful in diagnosis and differentiation of studied diseases.

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<p>Latest Advances of Long Non-Coding RNA SNHG5 in Human Cancers</p>

Cited by 18 publications

References 43 publications

SNHG5 knockdown alleviates neuropathic pain induced by chronic constriction injury via sponging miR‑142‑5p and regulating the expression of CAMK2A

SNHG5 knockdown alleviates neuropathic pain induced by chronic constriction injury via sponging miR‑142‑5p and regulating the expression of CAMK2A

RBM47/SNHG5/FOXO3 axis activates autophagy and inhibits cell proliferation in papillary thyroid carcinoma

Identification of Transcriptomic Differences between Lower Extremities Arterial Disease, Abdominal Aortic Aneurysm and Chronic Venous Disease in Peripheral Blood Mononuclear Cells Specimens

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