<p>Linc00511 Indicates A Poor Prognosis Of Liver Hepatocellular Carcinoma</p>

Abstract

ObjectiveTo uncover the specific function of linc00511 in the progression of liver hepatocellular carcinoma (LIHC) and the underlying mechanism.Patients and methodsGEPIA dataset containing 9736 LIHC samples and 857 normal samples were downloaded from TCGA. Expression pattern and prognostic potential of linc00511 in LIHC were analyzed. Subsequently, expression level of linc00511 in LIHC tissues collected in our hospital and cell lines were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Differential expressions of linc00511 in LIHC with different tumor grades and metastatic status were compared. After transfection of si-linc00511, proliferative and migratory changes in Huh7 and Hep3B cells were assessed by cell counting kit-8 (CCK-8), 5-ethynyl-2ʹ-deoxyuridine (EdU) and Transwell assay. Lastly, Pearson correlation analysis and qRT-PCR were conducted to investigate the interaction between linc00511 and miR-29c.ResultsLinc00511 was upregulated in LIHC tissues and cell lines. Its level was positively correlated to TNM staging, lymphatic metastasis and poor prognosis in LIHC patients. Knockdown of linc00511 attenuated proliferative and migratory abilities in Huh7 and Hep3B cells. In addition, miR-29c was downregulated in LIHC and negatively linked to linc00511 level. A negative interaction between linc00511 and miR-29c could be a regulatory feedback influencing the progression of LIHC.ConclusionLinc00511 accelerates the proliferation and migration in LIHC, thus aggravating tumor progression. Meanwhile, linc00511 could be utilized as a hallmark predicting poor prognosis in LIHC patients.

The dysregulation of NME1, LINC00511, and LINC01028 could disturb the regular apoptosis process and promote breast cancer in the Isfahan population: integrated bioinformatics and experimental analyses

“…Previous studies revealed that the ceRNA role of LINC00511 has been observed in the gastric cancer cell growth promotion process (32). It is demonstrated that the invasion and proliferation are also related to the up-regulation of LINC00511 and the poor prognosis of hepatocellular carcinoma Pingan Hu and others, " LINC00511 Indicates a poor prognosis of liver hepatocellular varcinoma (33). Also, the ceRNA role of LINC00511 in the T-cell acute lymphoblastic leukemia (34) and osteosarcoma (35) had been observed.…”

Prognostic significance of long intergenic non-protein-coding RNA 511expression in malignant tumors

“…In HCC, LINC00511 promoted the proliferation, colony formation, migration, and invasion of cancer cells by targeting miR-424 and miR-29c , and regulating the miR-195 / eyes absent homolog 1 axis. [ 14 – 16 ] Jiang et al [ 36 ] also suggested that silencing LINC00511 would suppress the proliferation, migration, and epithelial-mesenchymal transition of lung cancer cells by modulating the PTEN/AKT/FOXO1 axis. Moreover, Li et al [ 37 ] found that overexpression of LINC00511 enhanced the proliferation and invasion of glioma cells through inhibition of miR-124-3p and concomitant upregulation of cyclin D2.…”

“…[ 5 – 7 ] The long intergenic noncoding RNA 00511 ( LINC00511 ) was firstly identified in 2015 by Cabanski et al [ 8 ] Subsequently, several studies reported that abnormal LINC00511 expression was correlated with prognosis in patients with malignancies. Moreover, most studies suggested that LINC00511 could act as an oncogene and its high expression was predictive of poor prognosis in various malignancies, such as cervical cancer (CC), [ 9 , 10 ] ovarian cancer (OC), [ 11 – 13 ] hepatocellular carcinoma (HCC), [ 14 – 16 ] pancreatic cancer, [ 17 ] lung cancer, [ 18 , 19 ] breast cancer, [ 20 – 24 ] renal cancer, [ 25 ] and glioma. [ 26 , 27 ] Nevertheless, some studies also reported that LINC00511 could be a tumor suppressor, with high LINC00511 expression being associated with favorable prognosis of some cancer patients.…”

Long non-coding RNA LINC00511 regulates the expression of microRNA-625-5p and activates signal transducers and activators of transcription 3 (STAT3) to accelerate the progression of gastric cancer

“…Overexpression of lnc-MUC20-9 in bladder cancer cells leads to the reduced viability, colony formation, migration, invasion, and increased apoptosis [8]. LINC00511 is transcribed from chromosome 17q24.3 region, and it is upregulated in tumors such as hepatocellular carcinoma, colorectal cancer, and GC [9][10][11].…”