First-year university students are vulnerable to certain psychological disorders. Psychological Well-Being (PWB) is one of the resources they can use to face academic challenges. However, research focusing to identify PWB as protective factor among first-year university students is still rare. This study employs quantitative method involving 151 respondents from the Faculty of Psychology of University X in West Java. It uses a PWB scale composed by Ryff and Self Report Questionnaire (SRQ-20). It also employs simple multiple regression to determine the relation between PWB and symptoms of psychological disorders, on one hand, and stepwise multiple regression to find out which dimensions of PWB are significant to anticipate psychological disorder, on the other. This study argues that PWB, especially self-acceptance and environment mastery dimension, can be used as a protective factor against psychological disorders. Keywords: first-year university students, psychological disorders, psychological well-being