&lt;p&gt;Lnc HAGLR Promotes Colon Cancer Progression Through Sponging miR‐185‐5p and Activating CDK4 and CDK6 in vitro and in vivo&lt;/p&gt;

Sun, Weixuan; Nie, Wenting; Wang, Zhaoyi; Zhang, Haolong; Li, Yezhou; Fang, Xuedong

doi:10.2147/ott.s246092

Cited by 43 publications

(28 citation statements)

References 48 publications

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“…While the expression of HAGLR was upregulated in hepatocellular carcinoma and associated with tumor proliferative and metastatic 25 . Similar ndings in colon cancer and esophageal cancer were reported by Sun and Yang et al 26,27 . Interestingly, HAGLR coordinating with miRNA-19a-3p/TGFBR2 could promote the healing process of a femoral neck fracture.…”

Section: Discussionsupporting

confidence: 89%

Identification of a hypoxia-associated long non-coding RNA signature and nomogram as a prognostic target for clear cell renal cell carcinoma

Chen¹,

Pan²,

Jin³

et al. 2020

Preprint

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Background To develop a hypoxia-associated long non-coding (lncRNA) signature for risk stratification in clear cell renal cell carcinoma (ccRCC). Methods The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma (TCGA KIRC) dataset was downloaded and analyzed. Results Four prognostic hypoxia-associated lncRNAs were used for signature construction. The four lncRNAs were downregulated in high grade, advanced stage, and high-risk ccRCC. ccRCC patients in the high-risk group had a worse prognosis than those in the low-risk group. And the risk score was significantly higher in high grade and advanced stage. The signature had an independent and long-standing prognosis prediction ability up to 10-year follow-up. Notably, the risk score was significantly positively correlated with the infiltration abundances of six immune cells from the Tumor IMmune Estimation Resource (TIMER). The gene set enrichment analysis (GSEA) also suggested that the signature was involved in the metabolism and tumorigenesis, which were closely related to the hypoxic tumor microenvironment. Ultimately, a nomogram was built to predict the individual long-term survival possibility. Conclusions We have developed a new hypoxia-associated lncRNA signature, representing a promising tool for risk stratification tool in ccRCC. It might serve as a prognostic index to facilitate personalized counseling for treatment.

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Section: Discussionsupporting

confidence: 89%

Identification of a hypoxia-associated long non-coding RNA signature and nomogram as a prognostic target for clear cell renal cell carcinoma

Chen¹,

Pan²,

Jin³

et al. 2020

Preprint

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“…Therefore, the perception of miR-17-5p pathways could help in explaining the mechanisms of principal liver metastases in CRC (15). On the other hand, miR-185-5p and miR-125b-5p appear down-regulated in CRC tissue compared to normal mucosa in other existing studies (52,56). These results are similar to ours, implying that miR-185-5p and miR-125b-5p could bring new information for discriminating and stratifying CRC patients.…”

Section: Discussionsupporting

confidence: 88%

“…MiR-17-5p plays the role of oncomiR in CRC cases ( 50 ), while miR-125b-5p and miR-185-5p act as tumor suppressors ( 51 , 52 ). First, our results from the tissue study indicated that high levels of miR-17-5p in primary CRC could be associated with metastatic potential and serve as a predictive biomarker.…”

Section: Discussionmentioning

confidence: 99%

Predictive Efficacy of MiR-125b-5p, MiR-17-5p, and MiR-185-5p in Liver Metastasis and Chemotherapy Response Among Advanced Stage Colorectal Cancer Patients

et al. 2021

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MicroRNAs (miRNAs), a class of small non-coding RNAs represent potential biomarkers for colorectal cancer (CRC). The study hypothesized that miRNAs associated with liver metastases may also contribute to assessing treatment response when associated to plasma exosomes. In this study, we used two sets of biological samples, a collection of tumor tissues harvested from patients with CRC with and without liver metastases, and a collection of plasma from CRC patients with and without response to FOLFOX4/FOLFIRI regimens. We investigated 10 target miRNAs in the tissue of 28 CRC patients and identified miR-125b-5p, miR-17-5p, and miR-185-5p to be associated with liver metastasis. Further, we investigated the three miRNAs at the exosomal level in a plasma collection to test their association with chemotherapy response. Our data suggest that the elevated plasma levels of miR-17-5p and miR-185-5p could be predictive of treatment response. Overexpression of miR-17-5p and underexpression of miR-125b-5p and miR-185-5p in CRC tissue seem to be associated with metastatic potential. On the other hand, an increased expression of miR-125b-5p in plasma exosomes was potentially correlated with a more aggressive CRC phenotype.

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“…Alaiyan et al reported that CCAT1 was gradually upregulated during the progression of CRC and was associated with tumor metastasis [ 17 ]. HAGLR was proved to promote cell growth, migration, and invasion viabilities and inhibit cell apoptosis in CRC [ 18 ]. LncRNA MSC-AS1 is a new lncRNA that has been discovered in recent years, which is first found to be overexpressed in hepatocellular carcinoma tissues [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

LncRNA MSC-AS1 Promotes Colorectal Cancer Progression by Regulating miR-325/TRIM14 Axis

Wang

et al. 2021

Journal of Oncology

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Background. LncRNA MSC-AS1 has been reported to be a tumor promoter in hepatocellular carcinoma. However, the function of MSC-AS1 in colorectal cancer (CRC) has not been elucidated. It is designed to study the expression level of MSC-AS1 and investigate its biological effect on the progression of CRC. Methods. The expression patterns of MSC-AS1, miR-325, and TRIM14 were explored by RT-qPCR in CRC tissues and cells. The protein expression of TRIM14 was tested by Western blot assay. The association between MSC-AS1 expression and clinicopathological data was analyzed by chi-squared test. CCK-8 assay, colony formation, and Transwell assay were used to investigate the effect of MSC-AS1 on cell growth, invasion, and migration in CRC cells. The correlations among MSC-AS1, miR-325, and TRIM14 were analyzed by Pearson’s correlation coefficient analysis. Results. We found that MSC-AS1 and TRIM14 were upregulated in CRC tissues, while miR-325 was downregulated in CRC tissues. Functional experiments demonstrated that MSC-AS1 knockdown inhibited cell proliferation, migration, and invasion abilities in CRC cells. Additionally, miR-325 was proved to be a target miRNA of MSC-AS1, and TRIM14 might be a downstream gene of miR-325. Besides that, MSC-AS1 counteracted the inhibitory effect of miR-325 on the cell progression and TRIM14 expression. Conclusion. Our results indicated that MSC-AS1 facilitated CRC progression by sponging miR-325 to upregulate TRIM14 expression. We suggested that MSC-AS1 might be a potential lncRNA-target for CRC therapy.

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<p>Lnc HAGLR Promotes Colon Cancer Progression Through Sponging miR‐185‐5p and Activating CDK4 and CDK6 in vitro and in vivo</p>

Cited by 43 publications

References 48 publications

Identification of a hypoxia-associated long non-coding RNA signature and nomogram as a prognostic target for clear cell renal cell carcinoma

Identification of a hypoxia-associated long non-coding RNA signature and nomogram as a prognostic target for clear cell renal cell carcinoma

Predictive Efficacy of MiR-125b-5p, MiR-17-5p, and MiR-185-5p in Liver Metastasis and Chemotherapy Response Among Advanced Stage Colorectal Cancer Patients

LncRNA MSC-AS1 Promotes Colorectal Cancer Progression by Regulating miR-325/TRIM14 Axis

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