&lt;p&gt;LncRNA PTCSC3 and lncRNA HULC Negatively Affect Each Other to Regulate Cancer Cell Invasion and Migration in Gastric Cancer&lt;/p&gt;

Cai, Yi; Yang, Li; Sun, Bin; Wang, Hugen; Zhang, Weiping; Zhao, Yuanyuan; Zhao, Hua-Lu; Zhang, Jianlin; Xu, Jianming; Wang, Yalei

doi:10.2147/cmar.s254944

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…For instance, in thyroid cancer, PTCSC3 is downregulated in the plasma of patients with gastric cancer and can regulate multiple pathways, such as the Wnt and STAT3 signaling pathway, to impact cancer cellular behaviors including viability, migration and invasion ( 12 , 26 , 27 ). In addition, PTCSC3 is downregulated in gastric cancer and can interact with lncRNA HULC, HOXA11-AS and Linc-pint to suppress invasion and viability of cancer cells ( 28 , 29 ). Moreover, recent studies suggested that PTCSC3 is a potential biomarker for the treatment and prognosis of gastric cancer ( 29 , 30 ), whereas its role in TNBC is unknown.…”

Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA PTCSC3 suppresses triple‑negative breast cancer by downregulating long non‑coding RNA MIR100HG

et al. 2023

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Long non-coding RNA (lncRNA) PTCSC3 is characterized as a tumor suppressor in thyroid cancer and glioma. The present study aimed to investigate the role of PTCSC3 in triple-negative breast cancer (TNBC). A total of 82 patients with TNBC were enrolled in the present study. The results showed that PTCSC3 was downregulated, while lncRNA MIR100HG was upregulated in tumor tissues compared with that in adjacent non-cancerous tissues of patients with TNBC. The follow-up study showed that low expression levels of PTCSC3 and high expression levels of MIR100HG were closely associated with poor survival of patients with TNBC. The expression levels of MIR100HG were decreased with the clinic stages of TNBC, while the expression levels of MIR100HG showed the opposite trend. Correlation analysis showed that the expression levels of PTCSC3 and MIR100HG were significantly correlated in both tumor tissues and adjacent non-cancerous tissues. The overexpression of PTCSC3 inhibited the expression level of MIR100HG in TNBC cells, while the expression level of PTCSC3 was unaffected. Cell Counting Kit-8 and Annexin V-FITC Apoptosis flow cytometry assays showed that overexpression of PTCSC3 led to inhibition, while overexpression of MIR100HG led to the promotion of TNBC cells viability and inhibited apoptosis of TNBC cells. In addition, overexpression of MIR100HG attenuated the effects of PTCSC3 overexpression on cancer cell viability. However, the overexpression of PTCSC3 did not affect cancer cell migration and invasion. Western-blot analysis showed that PTCSC3 suppressed viability and promoted apoptosis of TNBC cells through the Hippo signaling pathway. Thus, the present study demonstrated that lncRNA PTCSC3 inhibits cancer cell viability and promotes cancer cell apoptosis in TNBC by downregulating MIR100HG.

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Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA PTCSC3 suppresses triple‑negative breast cancer by downregulating long non‑coding RNA MIR100HG

et al. 2023

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“…In GC tissues and cell lines, downregulation of PTCSC3 has been observed in several studies [ 20 – 23 ]. The role of lncRNA PTCSC3 in GC is schematically shown in Fig.…”

Section: The Expression Of Ptcsc3 In Different Cancersmentioning

confidence: 97%

A review on the biological roles of LncRNA PTCSC3 in cancerous and non-cancerous disorders

Ghasemian,

Poodineh

2023

Cancer Cell Int

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Long non-coding RNA papillary thyroid carcinoma susceptibility candidate 3 (LncRNA PTCSC3) is located on human chromosome 14q13.3. PTCSC3 functions as a tumor suppressor lncRNA to regulate essential cellular processes such as apoptosis, cell proliferation, migration, invasion, angiogenesis, and epithelial-to-mesenchymal transition. PTCSC3 is also involved in the regulation of the Wnt/β-catenin signaling pathway, aerobic glycolysis, and p53 pathways. Downregulation of PTCSC3 has been associated with an increased risk of many tumors such as thyroid, gastric, laryngeal, breast, cervical, oral, lung, and glioma cancers. In addition, dysregulation of PTCSC3 has been reported in non-cancerous disorders notably osteoporosis and periodontitis. However, a number of single nucleotide polymorphisms at PTCSC3 have been linked to a higher risk of human diseases. This literature review summarizes the diagnostic, prognostic, and the clinical value of abnormal expression of PTCSC3 in cancerous and non-cancerous disorders and comprehensively analyzes potential molecular regulatory mechanism related to PTCSC3, which is expected to provide clear guidance for future PTCSC3 research.

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Tumor- and metastasis-promoting roles of miR-488 inhibition via HULC enhancement and EZH2-mediated p53 repression in gastric cancer

et al. 2022

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<p>LncRNA PTCSC3 and lncRNA HULC Negatively Affect Each Other to Regulate Cancer Cell Invasion and Migration in Gastric Cancer</p>

Cited by 5 publications

References 28 publications

Long non‑coding RNA PTCSC3 suppresses triple‑negative breast cancer by downregulating long non‑coding RNA MIR100HG

Long non‑coding RNA PTCSC3 suppresses triple‑negative breast cancer by downregulating long non‑coding RNA MIR100HG

A review on the biological roles of LncRNA PTCSC3 in cancerous and non-cancerous disorders

Tumor- and metastasis-promoting roles of miR-488 inhibition via HULC enhancement and EZH2-mediated p53 repression in gastric cancer

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