Tumor- and metastasis-promoting roles of miR-488 inhibition via HULC enhancement and EZH2-mediated p53 repression in gastric cancer

Yang, Dejun; Shi, Mengyao; You, Qi; Hu, Zunqi; Xu, Jiapeng; Cai, Qing-Qing; Zhu, Zhenxin

doi:10.1007/s10565-022-09760-y

Cited by 4 publications

(2 citation statements)

References 54 publications

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“…It may also impact the immune response by binding to miR-488, thereby enhancing EZH2-H3K27me3 enrichment at the p53 promoter region, suppressing p53 expression, and promoting tumor growth and metastasis. Given its integral role in cancer cell survival and immune interactions, HULC could potentially serve as an effective therapeutic target for CRC [ 111 , 112 ].…”

Section: The Role Of Lncrnas In Tumor–stroma Immune Interplay Via Ext...mentioning

confidence: 99%

Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

Shakhpazyan,

Mikhaleva,

Bedzhanyan

et al. 2023

Biomedicines

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This comprehensive review elucidates the intricate roles of long non-coding RNAs (lncRNAs) within the colorectal cancer (CRC) microenvironment, intersecting the domains of immunity, intercellular communication, and therapeutic potential. lncRNAs, which are significantly involved in the pathogenesis of CRC, immune evasion, and the treatment response to CRC, have crucial implications in inflammation and serve as promising candidates for novel therapeutic strategies and biomarkers. This review scrutinizes the interaction of lncRNAs with the Consensus Molecular Subtypes (CMSs) of CRC, their complex interplay with the tumor stroma affecting immunity and inflammation, and their conveyance via extracellular vesicles, particularly exosomes. Furthermore, we delve into the intricate relationship between lncRNAs and other non-coding RNAs, including microRNAs and circular RNAs, in mediating cell-to-cell communication within the CRC microenvironment. Lastly, we propose potential strategies to manipulate lncRNAs to enhance anti-tumor immunity, thereby underlining the significance of lncRNAs in devising innovative therapeutic interventions in CRC.

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Section: The Role Of Lncrnas In Tumor–stroma Immune Interplay Via Ext...mentioning

confidence: 99%

Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

Shakhpazyan,

Mikhaleva,

Bedzhanyan

et al. 2023

Biomedicines

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“…[3] miRNAs play an important role in regulating gene expression by binding with 3ʹ-UTR of the target gene, dysregulation of miRNAs is implicated in the development of GC, which is possibly related to their roles in targeting tumor-suppressive or tumor-promoting genes. [4] Single nucleotide polymorphisms in miRNAs are believed to affect the occurrence and progression of cancer by altering the expression and biological functions of miR-NAs, miRNA single nucleotide polymorphisms such as miR-27a, miR-608, miR-196a-2 were found to be associated with GC. [5] miR-149 is a miRNA with essential roles in carcinogenesis, it is encoded by MIR149 gene on 2q37.3, the most appreciated mechanism of miR-149-5p dysregulation in cancer cells is the sequestering effects of these lncRNAs and circRNAs on it.…”

Section: Introductionmentioning

confidence: 99%

Update on the association of miR-149 rs2292832 C>T polymorphism with gastric cancer risk: A meta-analysis study of gastrointestinal cancers

Zhong,

Luo,

et al. 2023

Medicine

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Objective: Single nucleotide polymorphisms in microRNAs are believed to affect the occurrence and progression of cancer by altering the expression and biological functions of microRNAs. Several studies investigated the role of the miR-149 rs2292832 C>T polymorphism on the risk of gastric cancer (GC), but got conflicting results. Methods: We performed a comprehensive and systematic search through the PubMed MEDLINE, Google Scholar, Science Direct, Scopus, CNKI, and Web of science, 8 studies were included in the meta-analysis to determine whether miR-149 rs2292832 C>T polymorphism contributed to the risk of GC. Results: Pooled data indicated that miR-149 rs2292832 C>T polymorphism was not associated with GC risk. In the stratified analysis by ethnicity, miR-149 rs2292832 C>T polymorphism significantly increased GC risk under the allele comparison model (odds ratio [OR] = 1.27, 95% CI = 1.04–1.55, P heterogeneity = 0.18, P = .02), recessive model (OR = 1.44, 95% CI = 1.04–2.01, P heterogeneity = 0.19, P = .03) among Caucasians; but decreased GC risk under the allele comparison model (OR = 0.89, 95% CI = 0.81–0.98, P heterogeneity = 0.22, P = .02) and dominant model (OR = 0.82, 95% CI = 0.72–0.93, P heterogeneity = 0.15, P = .01) among Asian. Conclusion: Our meta-analysis suggests a positive correlation between miR-149 rs2292832 C>T polymorphism and GC development among Caucasians, but negative correlation among Asian population.

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MicroRNA-488: A miRNA with diverse roles and clinical applications in cancer and other human diseases

Yang,

Wang,

Hao

et al. 2023

Biomedicine & Pharmacotherapy

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Tumor- and metastasis-promoting roles of miR-488 inhibition via HULC enhancement and EZH2-mediated p53 repression in gastric cancer

Cited by 4 publications

References 54 publications

Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

Long Non-Coding RNAs in Colorectal Cancer: Navigating the Intersections of Immunity, Intercellular Communication, and Therapeutic Potential

Update on the association of miR-149 rs2292832 C>T polymorphism with gastric cancer risk: A meta-analysis study of gastrointestinal cancers

MicroRNA-488: A miRNA with diverse roles and clinical applications in cancer and other human diseases

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