&lt;p&gt;MicroRNA Profile Identifies miR-6165 Could Suppress Gastric Cancer Migration and Invasion by Targeting STRN4&lt;/p&gt;

Zhu, Wei; Li, Yang; Cao, Jian; Zhang, Wei; Wang, Quan; Zhang, Zhen; Gao, Zhidong; Ye, Yingjiang; Jiang, Kewei; Wang, Shan

doi:10.2147/ott.s208024

Cited by 5 publications

(6 citation statements)

References 30 publications

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“…miR‐6165 is predicted to be a target of circ_0001459. miR‐6165 can inhibit the migration and invasion of gastric cancer by regulating STRN4 11 . miR‐6165 is a tumor suppressor in colorectal cancer that can regulate IGF1R expression 12 .…”

Section: Discussionmentioning

confidence: 99%

“…miR‐6165 can inhibit the migration and invasion of gastric cancer by regulating STRN4. 11 miR‐6165 is a tumor suppressor in colorectal cancer that can regulate IGF1R expression. 12 The close interaction between miR‐6165 and circ_0001459 was confirmed in HCC cells; miR‐6165 inhibitor was found to reverse the functional changes in HCC cells caused by circ_0001459 knockdown.…”

Section: Discussionmentioning

confidence: 99%

“…MicroRNAs (miRNAs) are small noncoding RNAs that can directly regulate the levels of most mRNAs 10 . It has been found that the expression of miR‐6165 is downregulated in cancers and is related to the progression of cancers 11,12 . However, its effect on HCC remains unclear.…”

Section: Introductionmentioning

confidence: 99%

“… 10 It has been found that the expression of miR‐6165 is downregulated in cancers and is related to the progression of cancers. 11 , 12 However, its effect on HCC remains unclear. Furthermore, insulin‐like growth factor 1 receptor (IGF1R) plays a cancer‐promoting role in a variety of cancers, including HCC.…”

Section: Introductionmentioning

confidence: 99%

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Circular RNA circ_0001459 accelerates hepatocellular carcinoma progression via the miR‐6165/IGF1R axis

Shen

Zhao

Zeng

et al. 2022

Annals of the New York Academy of Sciences

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An increasing amount of evidence shows that circular RNAs (circRNAs) have critical effects on cancer progression and development; however, the biological function and potential molecular mechanism of circRNAs in hepatocellular carcinoma (HCC) are still unclear. CircRNA sequencing was used to identify differentially expressed circRNAs between HCC tissue and adjacent normal tissue. We found that circ_0001459 expression was significantly elevated in HCC tissue and cell lines. Furthermore, in vitro and in vivo functional experiments were carried out to detect the effects of circ_0001459 on HCC growth and metastasis. Knockdown of circ_0001459 significantly inhibited the proliferation, migration, and invasion of HCC cells, whereas upregulation of circ_0001459 had the opposite effect. Moreover, bioinformatics analysis, dual-luciferase reporter assay, RNA immunoprecipitation, and fluorescence in situ hybridization assays were used to predict and verify the interaction between circ_0001459, miR-6165, and the target gene IGF1R. Downregulation of circ_0001459 decreased IGF1R expression and inhibited epithelialto-mesenchymal transition, which could be rescued by treatment with a miR-6165 inhibitor. Mechanistically, we revealed that circ_0001459 could sponge miR-6165 and induce the upregulation of its downstream target IGF1R, thus significantly promoting the progression of HCC. Therefore, circ_0001459 could be a new potential therapeutic target for HCC patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Circular RNA circ_0001459 accelerates hepatocellular carcinoma progression via the miR‐6165/IGF1R axis

Shen

Zhao

Zeng

et al. 2022

Annals of the New York Academy of Sciences

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“…SMAGP encodes a transmembrane glycoprotein that plays an important role in tumor invasion and metastasis ( 45 – 47 ). STRN4 belongs to the striatin family and functions as a co-factor ( 48 ), particularly in cancer-related pathways ( 49 ) in prostate ( 50 ), lung ( 51 ), and gastric ( 52 ) cancers. In the current study, ZNF540 and SMAGP were identified as prognostic markers for LUAD for the first time, but their specific roles and potential regulatory mechanisms require further investigation.…”

Section: Discussionmentioning

confidence: 99%

CD8+ T Cell-Associated Gene Signature Correlates With Prognosis Risk and Immunotherapy Response in Patients With Lung Adenocarcinoma

Zhang

Guo

et al. 2022

Front. Immunol.

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The presence of infiltrating CD8+ T lymphocytes in the tumor microenvironment of lung adenocarcinoma (LUAD) is correlated with improved patient prognosis, but underlying regulatory mechanisms remain unknown. To identify biomarkers to improve early diagnosis and treatment of LUAD, we downloaded 13 immune cell line-associated datasets from the GEO database. We identified CD8+ T cell-associated genes via weighted correlation network analysis. We constructed molecular subtypes based on CD8+ T cell-associated genes and constructed a multi-gene signature. We identified 252 CD8+ T cell-associated genes significantly enriched in immune function-related pathways and two molecular subtypes of LUAD (immune cluster 1 [IC1] and IC2) using our CD8+ T cell-associated gene signature. Patients with the IC2 subtype had a higher tumor mutation burden and lower immune infiltration scores, whereas those with the IC1 subtype were more sensitive to immune checkpoint inhibitors. Prioritizing the top candidate genes to construct a 10-gene signature, we validated our model using independent GSE and TCGA datasets to confirm its robustness and stable prognostic ability. Our risk model demonstrated good predictive efficacy using the Imvigor210 immunotherapy dataset. Thus, we established a novel and robust CD8+ T cell-associated gene signature, which could help assess prognostic risk and immunotherapy response in LUAD patients.

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Cellular Impacts of Striatins and the STRIPAK Complex and Their Roles in the Development and Metastasis in Clinical Cancers (Review)

Li,

Martin,

Lane

et al. 2023

Cancers

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Striatins (STRNs) are generally considered to be cytoplasmic proteins, with lower expression observed in the nucleus and at cell–cell contact regions. Together with protein phosphatase 2A (PP2A), STRNs form the core region of striatin-interacting phosphatase and kinase (STRIPAK) complexes through the coiled-coil region of STRN proteins, which is crucial for substrate recruitment. Over the past two decades, there has been an increasing amount of research into the biological and cellular functions of STRIPAK members. STRNs and the constituent members of the STRIPAK complex have been found to regulate several cellular functions, such as cell cycle control, cell growth, and motility. Dysregulation of these cellular events is associated with cancer development. Importantly, their roles in cancer cells and clinical cancers are becoming recognised, with several STRIPAK components found to have elevated expression in cancerous tissues compared to healthy tissues. These molecules exhibit significant diagnostic and prognostic value across different cancer types and in metastatic progression. The present review comprehensively summarises and discusses the current knowledge of STRNs and core STRIPAK members, in cancer malignancy, from both cellular and clinical perspectives.

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<p>MicroRNA Profile Identifies miR-6165 Could Suppress Gastric Cancer Migration and Invasion by Targeting STRN4</p>

Cited by 5 publications

References 30 publications

Circular RNA circ_0001459 accelerates hepatocellular carcinoma progression via the miR‐6165/IGF1R axis

Circular RNA circ_0001459 accelerates hepatocellular carcinoma progression via the miR‐6165/IGF1R axis

CD8+ T Cell-Associated Gene Signature Correlates With Prognosis Risk and Immunotherapy Response in Patients With Lung Adenocarcinoma

Cellular Impacts of Striatins and the STRIPAK Complex and Their Roles in the Development and Metastasis in Clinical Cancers (Review)

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